AOGRAdvances in Obstetrics and Gynecology Research3083-48722981-8060Bio-Byword Scientific Publishing Pty. Ltd.10.26689/AOGR.v4i3.15269ArticleClinical Effect of Modified Continuous Locking Suture for Wound Reconstruction After Cold Knife Conization of the Cervixhttps://artdesignp.com/journal/AOGR/4/3/10.26689/AOGR.v4i3.15269YangJingbo,YangQing,YangJia,TongLingling,JingXinhui2026432026-08-31Objective: To evaluate the efficacy of modified continuous locking suture for wound reconstruction after cold knife conization (CKC) of the cervix. Methods: A total of 100 patients with high‑grade squamous intraepithelial lesions (HSIL) who underwent CKC between July 2022 and December 2023 were enrolled and divided into a study group (modified continuous locking suture, n = 50) and a control group (traditional U‑shaped suture, n = 50). Perioperative indicators and follow‑up outcomes were compared between the two groups. Results: Operative time, intraoperative blood loss, and hospital stay in the study group were significantly lower than those in the control group (P < 0.001). No statistically significant differences were observed between the two groups in terms of late postoperative bleeding, fever, margin negativity, satisfactory cervical molding, wound healing at 3 months, satisfactory cervical shaping at 6 months, cervical stenosis at 12 months, or HPV clearance rate (all P > 0.05). Conclusion: The modified continuous locking suture can shorten operative time and reduce blood loss without increasing the risk of complications, representing a safe and effective option for wound reconstruction after cervical conization.Cold knife conization, Continuous locking suture, High-grade squamous intraepithelial lesion, Wound reconstruction, Cervical stenosis

[1]   National Health Commission of the People's Republic of China, 2022, Guidelines for Diagnosis and Treatment of Cervical Cancer (2022 Edition). National Health Commission, [missing website link]. [2]   Zhao C, Bi H, Zhao Y, et al., 2022, Chinese Expert Consensus on the Management of Cervical High-Grade Intraepithelial Lesions. Chinese Journal of Clinical Obstetrics and Gynecology, 23(2): 220–224. [3]   Ye H, 2022, Advances in Diagnosis and Treatment of Cervical High-Grade Squamous Intraepithelial Lesions. Cancer Research on Prevention and Treatment, 49(6): 557–562. [4]   Kyrgiou M, Athanasiou A, Paraskevaidi M, et al., 2016, Adverse Obstetric Outcomes After Local Treatment for Cervical Preinvasive and Early Invasive Disease According to Cone Depth: Systematic Review and Meta Analysis. BMJ, 354: i3633. [5]   Wang X, Li L, Bi Y, et al., 2019, The Effects of Different Instruments and Suture Methods of Conization for Cervical Lesions. Scientific Reports, 9(1): 19114. [6]   Chen Y, Liu J, Liu YS, 2022, Application of Four Quadrant Suturing in Cold Knife Conization of the Cervix. Journal of Dalian Medical University, 44(6): 490–494. [7]   Cai L, Huang Y, Lin C, et al., 2020, A Comparison Study of Post Operative Infection Analysis of Cold Knife Conization and Loop Electrosurgical Excision Procedure for Cervical High Grade Squamous Intraepithelial Lesion. Translational Cancer Research, 9(2): 949–957. [8]   Vieira MA, de Araújo RLC, da Cunha Andrade CEM, et al., 2021, A Randomized Clinical Trial of a New Anti Cervical Stenosis Device After Conization by Loop Electrosurgical Excision. PLoS One, 16(1): e0242067. [9]   Li MZ, Li JR, Li X, et al., 2025, Chinese Cervical Cancer Screening Guidelines (II). Chinese Journal of Clinical Obstetrics and Gynecology, 26(1): 88–96. [10] Lu J, Han S, Li Y, et al., 2023, A Study on the Correlation Between the Prognosis of HPV Infection and Lesion Recurrence After Cervical Conization. Frontiers in Microbiology, 14: 1266254.