APMAdvances in Precision Medicine2424-85922424-9106Bio-Byword Scientific Publishing Pty. Ltd.10.26689/APM.v11i6.15121ArticleLongitudinal Safety Analysis of Chronic Resveratrol Supplementation: A Critical Review of the Interaction between Thyroid, Bone and Iron Metabolismhttps://artdesignp.com/journal/APM/11/6/10.26689/APM.v11i6.15121YuYi,GaoHuiyuan20261162026-06-26Objective: Resveratrol (3, 5, 4’-trihydroxy-trans-stilbene) is a natural polyphenol that has been found to have the effects of anti-aging, anti-inflammation, and metabolism. However, there are still no long-term safety data for resveratrol, so in this review, its effects on thyroid function, bone mineral density, and iron metabolism, etc., will be examined to explore its long-term safety and how its pharmacological properties may affect health in various ways. Methods: In April 2026, PubMed, EMBASE, Cochrane Library, and Web of Science were used for the search. The long-term safety, thyroid function, bone health, and iron metabolism of preclinical and clinical studies were also examined. Results: Generally speaking, the short-term clinical trials have demonstrated good tolerance; however, animal studies have shown that it may affect the activity of thyroid peroxidase, bone remodeling, and iron chelation. Conclusion: It is not yet known whether the results will help treat the disease in the long run; therefore, at present, this evidence cannot be applied. More good clinical trials need to be carried out to determine the impact on thyroid function, bone health, and iron homeostasis.Resveratrol,Long-term safety,Thyroid function,Bone mineral density,Iron metabolism

[1] Renaud S, de Lorgeril M, 1992, Wine, Alcohol, Platelets, and the French Paradox for Coronary Heart Disease. Lancet, 339(8808): 1523–1526. [2] Baur JA, Sinclair DA, 2006, Therapeutic Potential of Resveratrol: The in vivo Evidence. Nature Reviews Drug Discovery, 5(6): 493–506. [3] Howitz KT, Bitterman KJ, Cohen HY, et al., 2003, Small Molecule Activators of Sirtuins Extend Saccharomyces cerevisiae Lifespan. Nature, 425(6954): 191–196. [4] Wood JG, Rogina B, Lavu S, et al., 2004, Sirtuin Activators Mimic Caloric Restriction and Delay Ageing in Metazoans. Nature, 430(7004): 686–689. [5] Bhat KP, Lantvit D, Christov K, et al., 2001, Estrogenic and Antiestrogenic Properties of Resveratrol in Mammary Tumor Models. Cancer Research, 61(20): 7456–7463. [6] Karuppagounder SS, Pinto JT, Xu H, et al., 2009, Dietary Supplementation with Resveratrol Reduces Plaque Pathology in a Transgenic Model of Alzheimer’s Disease. Neurochemistry International, 54(2): 111–118. [7] Bent S, Tiedt TN, Odden MC, et al., 2003, The Relative Safety of Ephedra Compared with other Herbal Products. Annals of Internal Medicine, 138(6): 468–471. [8] Teschke R, Schwarzenboeck A, Akinci A, 2008, Kava Hepatotoxicity: A European View. The New Zealand Medical Journal, 121(1276): 90–98. [9] Walle T, Hsieh F, DeLegge MH, et al., 2004, High Absorption but very Low Bioavailability of Oral Resveratrol in Humans. Drug Metabolism and Disposition, 32(12): 1377–1382. [10] la Porte C, Voduc N, Zhang G, et al., 2010, Steady-state Pharmacokinetics and Tolerability of Trans-resveratrol 2000 mg Twice Daily with Food, Quercetin and Alcohol (ethanol) in Healthy Human Subjects. Clinical Pharmacokinetics, 49(7): 449–454.