APMAdvances in Precision Medicine2424-85922424-9106Bio-Byword Scientific Publishing Pty. Ltd.10.26689/APM.v11i8.16036ArticleDiscussion on the Clinical Diagnostic Value of Serum Immunofixation Electrophoresis, Protein Electrophoresis, Immunoglobulin and Light Chain Quantification in Multiple Myelomahttps://artdesignp.com/journal/APM/11/8/10.26689/APM.v11i8.16036YangCan20261182026-08-26Objective: To explore the value of serum, immunofixation electrophoresis, immunoglobulin and light chain detection in the diagnosis of multiple myeloma (MM). Methods: The study started and ended in January 2025 and January 2026 respectively. 100 MM patients admitted to our hospital during this period were included in the analysis. All enrolled patients underwent protein electrophoresis, immunofixation electrophoresis, immunoglobulin and light chain detection, and the test results were statistically collected. Results: During immunofixation electrophoresis detection, 81 (81.00%) of the 100 MM patients had significantly concentrated monoclonal bands, including 21 (25.93%) cases of IgA type, 44 (54.32%) cases of IgG type, and 1 (1.23%) case of IgM type. There were 15 (18.52%) cases of free light chain type; protein electrophoresis test showed that among 100 MM patients, a total of 67 (67.00%) cases had M protein bands, including 19 (28.36%) cases of IgA type, 35 (52.24%) cases of IgG type, and 1 IgM type. (1.49%) cases, 12 (17.91%) cases of free light chain type; among 100 MM patients, a total of 80 (80.00%) cases had abnormal immunoglobulin or light chain content, including 19 (23.75%) cases of IgA type and 44 (55.00%) cases of IgG type. Among them, there were 1 (1.25%) case of IgM type and 16 (20.00%) cases of free light chain type; the detection rate of serum protein electrophoresis was lower than that of immunofixation electrophoresis, immunoglobulin and light chain detection, respectively. The total detection rate of combined detection was higher than that of single detection, and the difference was valuable (p < 0.05). Discussion: Serum immunofixation electrophoresis has a high diagnostic value in the clinical diagnosis of MM, and the value of joint serum protein electrophoresis, immunofixation electrophoresis, immunoglobulin and light chain detection is even more significant, which can further increase the detection rate and is of great significance to the assessment and diagnosis of the disease.Multiple myeloma, Serum immunofixation electrophoresis, Immunoglobulin, Protein electrophoresis, Light chain quantification, Diagnostic value

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