APMAdvances in Precision Medicine2424-85922424-9106Bio-Byword Scientific Publishing Pty. Ltd.10.26689/APM.v11i8.16045ArticleEffect of Olanzapine Combined with Paliperidone on Improving Positive Symptoms and Social Functions in Patients with Refractory Schizophreniahttps://artdesignp.com/journal/APM/11/8/10.26689/APM.v11i8.16045SuJianzhong20261182026-08-26Objective: To analyze the effect of olanzapine combined with paliperidone in the treatment of refractory schizophrenia, especially its intervention value on patients’ positive symptoms and social functions. Methods: 86 cases of refractory schizophrenia hospitalized in the psychiatry department of our hospital from January 2024 to January 2025 were collected and divided into two groups according to the random number table method. A control group (olanzapine alone) and an observation group (olanzapine combined with paliperidone sustained-release tablets) were established. The treatment courses were both 12 weeks. PANSS was used to evaluate patients’ positive symptoms before treatment and at 4, 8, and 12 weeks of treatment, and PSP was used to evaluate social functions. The clinical efficacy of the two groups was compared. Results: After treatment, the PANSS positive symptom scores of the two groups were reduced, and the PSP scores were increased. The observation group improved better in various indicators, and the total effective rate was higher than that of the control group (p < 0.05). Conclusion: Olanzapine combined with paliperidone can effectively improve the positive symptoms and overall mental state of patients with refractory schizophrenia, promote the recovery of social functions, and is worthy of promotion.Refractory schizophrenia, Olanzapine, Paliperidone, Positive symptoms, Social function, Clinical efficacy

[1] Hu Y, Sun J, 2025, Effects of Paliperidone Combined with Olanzapine on Glucose and Lipid Metabolism and Serum BDNF and IL-1β Levels in Patients with Schizophrenia. Heilongjiang Medicine, 49(20): 2507–2510. [2] Cao R, 2025, Effect of Low-Dose Paliperidone Combined with Olanzapine in the Treatment of Patients with Schizophrenia. Chinese Folk Medicine, 37(18): 90–92. [3] Sun G, Liao L, 2025, Comparison of the Efficacy of Paliperidone Palmitate Long-Acting Injection and Olanzapine in the Treatment of Community Patients with Schizophrenia. Contemporary Medical Review, 23(26): 92–94. [4] Hao B, Yang X, Li S, 2025, Effect of Paliperidone Combined with Olanzapine on Long-Term Hospitalized Patients with Schizophrenia. Psychological Monthly, 20(15): 150–152. [5] Hu Z, Jin X, Wang Q, et al., 2025, The Efficacy of Paliperidone Combined with Olanzapine in the Treatment of Adult Patients with Acute Schizophrenia and Its Impact on PANSS and PSP Scores. General Medicine Clinical and Education, 23(4): 307–310. [6] Li X, Li J, Liu R, 2023, The Efficacy of Paliperidone Combined with Olanzapine on Manic Episodes in BPD and Its Impact on the Intestinal Flora of Patients. Shenzhen Journal of Integrated Traditional Chinese and Western Medicine, 33(10): 15–19. [7] Lu W, Wang T, He X, 2022, Effects of Olanzapine Combined with Paliperidone on the Efficacy and Metabolism of Patients with Schizophrenia. Modern Chinese Physicians, 60(31): 82–85. [8] He X, Li P, Wang N, et al., 2025, Comparative Study on the Clinical Effects of Paliperidone Palmitate and Olanzapine in the Treatment of Schizophrenia. Electronic Journal of Modern Medicine and Health Research, 9(9): 75–77.