BASBone and Arthrosurgery Science3083-48562981-8222Bio-Byword Scientific Publishing Pty. Ltd.10.26689/BAS.v4i4.15274ArticleChemerin in Arthritis: Molecular Basis, Clinical Implications, and Translational Perspectiveshttps://artdesignp.com/journal/BAS/4/4/10.26689/BAS.v4i4.15274HuangLiangchao,ZhangDong,PengJinlong,YangXiren2026442026-08-31Against global aging and rising obesity, arthritis—a highly prevalent chronic musculoskeletal disease—causes high morbidity and disability, with unclear pathogenesis and no curative therapies. Chemerin, a dual chemokine-adipokine linking metabolic dysregulation to chronic inflammation, plays a pivotal role in arthritis progression, yetcontroversies persist over subtype-specific functions and its bidirectional effects. This review (covering literature from Jan 1997 to Mar 2026) shows aberrant chemerin overexpression in the serum and local joints of osteoarthritis(OA) and rheumatoid arthritis(RA) patients, which modulates disease via multiple pathways, while its mechanisms in gouty arthritis(GA) and spondyloarthritis(SpA) remain elusive. The Chemerin/ChemR23 axis is a promising therapeutic target; future studies should resolve existing controversies and fill knowledge gaps to clarify its precise regulatory mechanisms.Chemerin, ChemR23, Arthritis, Osteoarthritis, Rheumatoid arthritis, Gouty arthritis, Inflammation regulation, Cartilage degeneration

[1] Taylor EB, 2021, The Complex Role of Adipokines in Obesity, Inflammation, and Autoimmunity. Clinical Science, 135(6): 731–752. [2] Man AWC, Xia N, Li H, 2025, Vascular Effects of Perivascular Adipose Tissue-Derived Chemerin in Obesity-Associated Cardiovascular Disease. Cardiovascular Diabetology, 24(1): 249. [3] Wang J, Deng J, Xiao T, et al., 2026, Decoding Chemerin Proteolytic Processing and Isoform Signaling Across Disease Contexts. iScience, 29(4): 115259. [4] Zhang C, Lin Y, Yan CH, et al., 2022, Adipokine Signaling Pathways in Osteoarthritis. Frontiers in Bioengineering and Biotechnology, 10: 865370. [5] Wen RM, Wang HX, 2025, Effect of Adipokines on Bone Marrow Mesenchymal Stem Cell Function. World Journal of Stem Cells, 17(5): 106150. [6] Liu A, Liu Y, Wang J, et al., 2024, Structural basis for Full-Length Chemerin Recognition and Signaling Through Chemerin Receptor 1. Commun Biol, 7: 1598. [7] Laurindo LF, de Maio MC, Barbalho SM, et al., 2022, Organokines in Rheumatoid Arthritis: A Critical Review. Int J Mol Sci, 23(11): 6193. [8] Jeong E, Jung JY, Lee MJ, et al., 2023, A Link Between CD8+CD27-CD28- T Cells Expressing Chemerin Chemokine-Like Receptor 1 and Rheumatoid Arthritis. Clinical and Experimental Rheumatology, 41(5): 1105–1113. [9] Gonzalez-Ponce F, Gamez-Nava JI, Perez-Guerrero EE, et al., 2021, Serum Chemerin Levels: A Potential Biomarker of Joint Inflammation in Women with Rheumatoid Arthritis. PloS one, 16(9): e0255854. [10] Bilski J, Schramm-Luc A, Szczepanik M, et al. Adipokines in Rheumatoid Arthritis: Emerging Biomarkers and Therapeutic Targets. Biomedicines, 11(11): 2998.