JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/JCNR.v10i8.15428ArticleEffects of Different Intraoperative Blood Salvage Methods on Blood Protection During Coronary Artery Bypass Graftinghttps://artdesignp.com/journal/JCNR/10/8/10.26689/JCNR.v10i8.15428ZhangQinhu,ZhuKun20251082025-08-31Objective: To comparatively analyze the clinical efficacy and blood protection value of three different intraoperative blood salvage methods in patients undergoing coronary artery bypass grafting (CABG) under cardiopulmonary bypass (CPB), so as to screen the optimal intraoperative blood salvage regimen suitable for cardiac surgery and provide evidence-based references for optimizing the perioperative patient blood management system in cardiac surgery. Methods: A total of 135 patients with coronary artery disease who underwent elective isolated CABG with CPB in our hospital from January 2022 to December 2025 were enrolled and randomly divided into three groups using the random number table method, with 45 cases in each group. Group A adopted the conventional direct intracardiac suction autologous blood transfusion mode; Group B received non-washed intraoperative blood filtration and salvage transfusion; Group C applied fully automatic washed autologous blood salvage mode. The intraoperative volume of autologous blood transfusion and total perioperative allogeneic blood product transfusion volume were recorded throughout the operation. Hemoglobin (Hb), hematocrit (Hct), platelet count (PLT), serum free hemoglobin (FHb), and coagulation function indicators were detected at three time points: preoperatively, immediately after CPB termination, and 24 hours postoperatively. Postoperative 24-hour mediastinal drainage volume, incidence of transfusion adverse reactions, and rate of reoperation for hemostasis were statistically analyzed. Results: There were no significant differences in baseline clinical data among the three groups (p > 0.05). Compared with Group A and Group B, Group C exhibited significantly lower perioperative transfusion volumes of allogeneic red blood cells and fresh frozen plasma, as well as a markedly higher effective volume of salvaged autologous blood (p < 0.05). At the time points immediately after CPB termination and 24 hours postoperatively, Group C had significantly lower serum FHb levels and higher Hb and Hct levels than Group A and Group B (p <0.05). No significant differences were observed in postoperative mediastinal drainage volume and reoperation hemostasis rate among the three groups (p >0.05). Two cases of mild hemolysis-related adverse reactions occurred in Group B, whereas no adverse events were recorded in Group A and Group C. Conclusion: The washed autologous blood salvage mode presents superior blood protection efficacy in CABG surgery with CPB. It can effectively remove fragmented red blood cells, inflammatory mediators, and harmful impurities in salvaged blood, reduce allogeneic blood product transfusion, and lower the risks of intraoperative red blood cell damage and hemolysis. With higher clinical safety and practicability, this mode can be promoted as a routine intraoperative blood protection strategy in cardiac surgery.Coronary artery bypass grafting, Cardiopulmonary bypass, Autologous blood salvage, Blood protection, Free hemoglobin

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