PARProceedings of Anticancer Research2208-35452208-3553Bio-Byword Scientific Publishing Pty. Ltd.10.26689/PAR.v10i5.15676ArticleA Study on the Specific, Organ-specific Patterns of Recurrence after Surgical Treatment for Gastric Adenocarcinoma, Based on the SEER Databasehttps://artdesignp.com/journal/PAR/10/5/10.26689/PAR.v10i5.15676ZhangShiqi,XuWei,QiuYue,GaoCaiyue,WangXiaoyan,ManChangfeng,FanYu20261052026-10-15Metastasis remains the main reason why gastric cancer treatment fails and why patients die. Yet metastatic lesions are not interchangeable. Peritoneal, hepatic, pulmonary, bone, and brain metastases differ in how often they appear, which patients they affect, and how long patients survive after diagnosis. The Surveillance, Epidemiology, and End Results (SEER) database is a large North American cancer registry. It has been used widely in retrospective work on organ-specific metastasis in gastric cancer. In this review, we examine SEER-based studies on metastasis to the peritoneum, liver, lung, bone, and brain. We compare reported incidence, clinicopathological correlates, survival estimates, and the value of prediction models. We also discuss differences among patient subgroups and the limitations that come with using SEER for this purpose. The aim is to help clinicians think about risk stratification, staging, and individualized decisions for patients with metastatic gastric cancer.Gastric cancer, SEER database, Distant metastasis, Organ-specific, Prognosis, Survival curve

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