AOGRAdvances in Obstetrics and Gynecology Research3083-48722981-8060Bio-Byword Scientific Publishing Pty. Ltd.10.26689/aogr.v2i1.6084ArticleEffects of Gestational Diabetes Mellitus on Offspring’s Neurobehavioral Development: A Retrospective Cohort Studyhttps://artdesignp.com/journal/AOGR/2/1/10.26689/aogr.v2i1.6084SunJiali,HuangBo,QiuHainan,LiChunmei,LuXiaohui,JinYuqi,WangFengdong2024212024-02-23Objective: To evaluate the association between gestational diabetes mellitus (GDM) and offspring neurobehavioral development. Methods: A total of 280 infants born to mothers with or without GDM were recruited, and their neurobehavioral development was assessed using the Children’s Neuropsychological and Behavioral Scale (CNBS). Results: Infants born to mothers with GDM exhibited significantly lower development quotient (DQ) scores at the 1st, 3rd, 6th, 8th, and 12th months after birth. Conclusion: GDM may adversely affect offspring neurobehavioral development, with this effect persisting despite interventions implemented during pregnancy.

American Diabetes Association Professional Practice Committee, 2022, 10. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes-2022. Diabetes Care, 45(Suppl 1): S144–S174. https://doi.org/10.2237/dc22-S010

Zhao J-P, Levy E, Fraser WD, et al., 2014, Circulating Docosahexaenoic Acid Levels are Associated with Fetal Insulin Sensitivity. PLoS One, 9(1): e85054. https://doi.org/10.1371/journal.pone.0085054

Huynh J, Dawson D, Roberts D, et al., 2015, A Systematic Review of Placental Pathology in Maternal Diabetes Mellitus. Placenta, 36(2): 101–114. https://doi.org/10.1016/j.placenta.2014.11.021

Deniz Dincer U, 2014, Fetal Exposure to a Diabetic Intrauterine Environment Resulted in a Failure of Cord Blood Endothelial Progenitor Cell Adaptation Against Chronic Hypoxia. Stem Cells Cloning, 8: 1–14. https://doi.org/10.2147/SCCAA.S73658

Salmaso N, Jablonska B, Scafidi J, et al., 2014, Neurobiology of Premature Brain Injury. Nat Neurosci, 17(3): 341–346. https://doi.org/10.1038/nn.3604

Najjar S, Pearlman DM, 2015, Neuroinflammation and White Matter Pathology in Schizophrenia: Systematic Review. Schizophr Res, 161(1): 102–112. https://doi.org/10.1016/j.schres.2014.04.041