AOGRAdvances in Obstetrics and Gynecology Research3083-48722981-8060Bio-Byword Scientific Publishing Pty. Ltd.10.26689/aogr.v2i2.7123ArticleThe Effect of Assisted Reproductive Technology on Morbidity and Mortality of Twin Premature — A Secondary Publicationhttps://artdesignp.com/journal/AOGR/2/2/10.26689/aogr.v2i2.7123CeranBurak,ÇakirUfuk,TuğcuAli Ulaş,TaymanCüneyt2024222024-06-13Objective: It is thought that twin neonates born from pregnancies resulting from assisted reproductive technology (ART) are clinically riskier than twin neonates born from spontaneous pregnancy. However, information on the risks in premature infants born as a result of ART pregnancies is limited. In our study, premature twin infants born from ART and spontaneous pregnancies were compared to clinical outcomes. Method: All premature twin infants hospitalized in our unit between September 2017 and September 2019 and born under 32 weeks of gestation were included in our study. Demographic and clinical results of premature twins born as a result of spontaneous and ART pregnancies were compared. Results: A total of 142 premature twins, 116 (81.6%) in the spontaneous twin group and 26 (18.4%) in the ART twin group, were included in the study. Demographic and clinical features were similar between ART and spontaneous twin groups (P > 0.05). Conclusion: Our study determined that premature infants born due to ART pregnancies did not have any additional risk compared to spontaneous infants. This result shows that the main determinants of clinical outcomes in premature infants are gestational week and birth weight.

Özçil MD, 2021, Comparison of Feto-Maternal Effects of Twin Pregnancies and Twin Pregnancies Occurred with Assisted Reproductive Techniques. J Acad Res Med.11(1): 17–23.

Papiernik E, Zeitlin J, Delmas D, et al., 2010, Differences in Outcome Between Twins and Singletons Born very Preterm: Results from A Population-Based European Cohort. Hum Reprod, 25(4): 1035–1043.

Lin D, Li P, Fan D, et al., 2021, Association Between IVF/ICSI Treatment and Preterm Birth and Major Perinatal Outcomes among Dichorionic-Diamnionic Twin Pregnancies: A Seven-Year Retrospective Cohort Study. Acta Obstet Gynecol Scand, 100(1): 162–169.

Lubchenco LO, Hansman C, Dressler M, et al., 1963, Intrauterine Growth as Estimated from Liveborn Birth-Weight Data at 24 to 42 Weeks of Gestation. Pediatrics. 32: 793–800.

Wynn JL, Wong HR, Shanley TP, et al., 2014, Time for a Neonatal-Specific Consensus Definition for Sepsis. Pediatr Crit Care Med, 15(6): 523–528.

Özkan H, Erdeve Ö, Kanmaz Kutman HG, 2018, Turkish Neonatal Society Guideline on the Management of Respiratory Distress Syndrome and Surfactant Treatment. Turkish Pediatrics Research. 53(1): S45–S54.

Tayman C, Cakir U, Yucel C, et al., 2019, Is Endocan a Novel Diagnostic Marker for the Severity of Bronchopulmonary Dysplasia in Very Low Birth Weight Infants? Arch Bronconeumol., 55(9): 465–471.

International Committee for the Classification of Retinopathy of Prematurity, 2005, The International Classification of Retinopathy of Prematurity Revisited. Arch Ophthalmol., 123(7): 991–999.

Allan WC, Volpe JJ, 1986, Periventricular-Intraventricular Hemorrhage. Pediatr Clin North Am., 33(1): 47–63.

Bell MJ, Ternberg JL, Feigin RD, et al., 1978, Neonatal Necrotizing Enterocolitis. Therapeutic Decisions Based Upon Clinical Staging. Ann Surg., 187(1): 1–7.

Cakir U, Tayman C, 2019, A Mystery of Patent Ductus Arteriosus and Serum Osmolality in Preterm Infants. Am J Perinatol. 36(6): 641–646.

Güler AE, Pehlivan H, Korucuo?lu Ü, et al., 2016, Perinatal Outcomes of Twin Pregnancies Occurring with Spontaneous and Assisted Reproductive Reproductive Techniques. Gaziosmanpa?a Univ. Faculty of Medicine Journal, 8(4): 256–262.

Ya?ar BN, Terzio?lu F, 2016, Perinatal Results in Assisted Reproductive Techniques. Anatolian Hem?. and Right. Know. Journal, 19(2): 139–144.

Mutlu B, Korkmaz A, Yi?it S, et al., 2010, Determination of Gestational Age with New Ballard Scoring in Babies Born with Assisted Reproductive Technology. Journal of Child Health and Diseases, 53(2): 98–106.

Çakar E, Kavuncuo?lu S, Aldemir EY, et al., 2014, Features of Multiple Pregnancies Obtained by In Vitro Fertilization or Spontaneously. Pediatr Int., 56(5): 735–741.

Shevell T, Malone FD, Vidaver J, et al., 2005, Assisted Reproductive Technology and Pregnancy Outcome. Obstet Gynecol., 106(5):1039–1045.

Vasario E, Borgarello V, Bossotti C, et al., 2010, IVF Twins have Similar Obstetric and Neonatal Outcome as Spontaneously Conceived Twins: A Prospective Follow-Up Study. Reprod Biomed Online, 21(3): 422–428.

Güney M, Oral B, Mungan T, et al., 2006, Antepartum, Intrapartum and Perinatal Outcomes of Twin Pregnancies After In Vitro Fertilization. J Turkish-German Gynecol Assoc., 7(2): 115–119.

Baxi A, Kaushal M, 2008, Outcome of Twin Pregnancies Conceived After Assisted Reproductive Techniques. J Hum Reprod Sci., 1(1): 25–28.

Ramo?lu M, Kavuncuo?lu S, Özbek S, et al., 2014, Spontaneous and In Vitro

Prenatal and Physical Growth Characteristics of Babies Born Prematurely from Fertilized Multiple Pregnancies. Turkish Ped Res., 49: 17–24.

Özkan ZS, At?lgan R, Atl? H, et al., 2013, Perinatal Outcome of Multiple Pregnancies Achieved with Assisted Reproductive Techniques. J Eagle, 24(3): 151–156.

Tosun Ö, Yüksel Karatoprak E, Oval? HF, 2018, Evaluation of Multiple Pregnancies Occurring with Assisted Reproductive Techniques and Postnatal Cost Analysis. Anadolu Clinic. Know Medicine. Journal, 23(3): 177–182.

Ça?l?yan E, Sar?da? Demir S, Özmen S, et al., 2020, Comparison of Obstetric and Perinatal Outcomes in In Vitro Fertilization (IVF) and Spontaneous Dichorionic Diamniotic (DDA) Twin Pregnancies. TJRMS, 4(3): 73–77.

Wang AY, Safi N, Ali F, et al., 2018, Neonatal Outcomes Among Twins Following Assisted Reproductive Technology: An Australian Population-Based Retrospective Cohort Study. BMC Pregnancy Childbirth, 18(1): 320.

Victora JD, Silveira MF, Tonial CT, et al., 2020, Prevalence, Mortality and Risk Factors Associated with Very Low Birth Weight Preterm Infants: An Analysis of 33 Years. J Pediatr (Rio J), 96(3): 327–332.

Chughtai AA, Wang AY, Hilder L, et al., 2018, Gestational Age-Specific Perinatal Mortality Rates for Assisted Reproductive Technology (ART) and Other Births. Hum Reprod., 33(2): 320–327.

Yarci E, Alyamac Dizdar E, Oncel MY, et al., 2014, Successful Management of Twin Anemia/Polycythemia Sequence by Syngeneic Partial Exchange Transfusion. Fetal Diagnosis Ther., 36(3): 251–254.