CNRClinical Neuroscience Research3083-48992981-8133Bio-Byword Scientific Publishing Pty. Ltd.10.26689/cnr.v2i1.6736ArticleApplication of Cognitive Training Therapy for Alzheimer’s Disease and Evaluation of its Efficacyhttps://artdesignp.com/journal/CNR/2/1/10.26689/cnr.v2i1.6736ChangSha,ZhangYu,WangXiaohui,LiZhi,WangLe2024212024-05-14Objective: The purpose of this study is to conduct in-depth research on the cognitive training treatment of Alzheimer’s disease and evaluate its efficacy. Methods: 74 cases of Alzheimer’s disease patients in the hospital were randomly selected for analysis and study from January 2023 to December 2023. The 74 patients were divided into two groups, 37 cases in the control group received conventional drug treatment, while 37 cases in the study group received conventional drug treatment combined with cognitive training. The cognitive functions of the two groups of patients before and after receiving the two different treatment methods were compared. Results: The cognitive impairment symptoms of patients in both groups were alleviated to a certain degree. The ADAS-Cog score of the study group was significantly lower than that of the control group, and the CDT, RVR, TMT-A, DS, FOME, and BD scores were higher than those of the control group, P < 0.05. Conclusion: After the combined intervention of medication and cognitive training therapy, the cognitive function of patients with Alzheimer’s disease was significantly improved, which increased the patients’ rehabilitation effect and quality of life, so this combined therapy is worth further research for widespread application.

Li CX, Fang Y, Jiang N, et al., 2021, Cognitive Improvement of Mild to Moderate Alzheimer’s Disease Patients by Adaptive Cognitive Training. Journal of Hunan Institute of Technology (Natural Science Edition), 34(04): 43–46.

Wu LY, 2023, Early Diagnosis and Treatment of Alzheimer’s Disease. Population and Health, 2023(09): 89–92.

Wang L, He Y, Li YM, et al., 2023, Application of Cognitive Intervention based on VR Technology Combined with Individualized Chemical Recreational Therapy in Patients with Mild-to-moderate Alzheimer’s Disease. Contemporary Nurses, 30(11): 37–41.

Zhang RF, Zhu JZ, Hu JQ, et al., 2023, Effects of Regression Family Intervention on Cognitive Function and Quality of Life in Patients with Alzheimer’s Disease. Journal of Nursing, 38(22): 106–110.

Zheng YJ, Zhang YQ, Gong W, 2023, Effects of Recreational Cognitive Training Combined with Psychological Liaison Care on Patients with Mild to Moderate Alzheimer’s Disease. Psychology Monthly, 18(22): 204–206.

Li N, Wang CL, Fang XN, et al., 2023, Evidence-based Practice of Rehabilitation Training for Patients with Mild to Moderate Alzheimer’s Disease. China Practical Medicine, 18(24): 152–157.

Xu QC, Du MZ, 2023, Effects of Virtual Technology Combined with Conventional Cognitive Rehabilitation Training on Cognitive Function in Patients with Alzheimer’s Disease. Medical Theory and Practice, 36(24): 4298–4300.

Han GH, Pang XL, Sun HL, et al., 2021, Quality Evaluation of Meta-analytic Reports of Cognitive Interventions for Alzheimer’s Disease Patients in China. Chinese Family Medicine, 19(11): 1946–1950.

Ni Z, Sun GQ, Jiang ML, 2023, Effects of Multisensory Stimulation Combined with Early Cognitive Rehabilitation Training on Cognitive Ability and Mental Status of Patients with Alzheimer’s Disease. Zhejiang Medicine, 45(04): 404–407 + 415.

Lin XY, Ye H, Chen H, 2023, Effects of Cognitive-perceptual Dysfunction Training Combined with Occupational Therapy on the Recent Rehabilitation Effect and Prognosis of Patients with Alzheimer’s Disease. Chinese and Foreign Medical Research, 21(05): 149–153.

Wang J, Yuan J, Wang L, 2022, Clinical Efficacy of Aripiprazole and Donepezil Combined with Functional Training in the Treatment of Alzheimer’s Disease and its Effect on Patients’ Cognitive Function and Behavioral Ability. Journal of Clinical Rational Drug Use, 15(27): 73–76.

Cai LL, Huang ZH, Yu ZG, 2022, Effects of Cognitive Function Training Combined with Daily Living Ability Training on Patients with Alzheimer’s Disease. Chinese Contemporary Medicine, 29(19): 90–93.

Xiao GX, 2023, Clinical Efficacy of Transcranial Direct Current Stimulation Combined with Cognitive Training in Alzheimer’s Disease and its Neural Mechanism, thesis, Anhui Medical University.

Hu FX, 2022, Effects of Comprehensive Rehabilitation Training Combined with Donepezil Hydrochloride on Cognitive Function and Quality of Life in Patients with Mild-to-moderate Alzheimer’s Disease. Reflexology and Rehabilitation Medicine, 3(07): 171–173.

Zhao XY, Huang XX, Wan QQ, 2021, An Integrative Review of Exercise Combined with Cognitive Training in Patients with Mild Cognitive Impairment and Alzheimer’s Disease. Chinese Nursing Education, 18(12): 1098–1105.