CNRClinical Neuroscience Research3083-48992981-8133Bio-Byword Scientific Publishing Pty. Ltd.10.26689/cnr.v3i3.12319ArticleExploration of a Combined Treatment Plan for Alleviating and Controlling the Progression of Amyotrophic Lateral Sclerosis (ALS)https://artdesignp.com/journal/CNR/3/3/10.26689/cnr.v3i3.12319FanXiaole,KangShiyu,LiYuelong,HuangGuojun,TaoQiqiang2025332025-10-17Purpose: This article aims to discuss five medical intervention strategies required for patients with amyotrophic lateral sclerosis (ALS) and provide a reference for intervening in this challenging disease. Methods: A retrospective analysis was conducted to identify existing issues in the treatment of ALS patients. A comparative analysis was performed to examine the nature, characteristics, and methods of previous intervention approaches. Results: Early identification and intervention, the application of rational combined treatment approaches, the improvement of comprehensive physical and mental rehabilitation systems, and the exploration of new treatment strategies provide a guarantee for effective intervention treatment of ALS patients. Conclusion: This article proposes the addition of a combined treatment approach involving the elimination of excessive glutamate from the body, which is theoretically reasonable, safe, and simple to implement. This approach has the potential to enhance the therapeutic effects and improve the individual prognosis of ALS patients. Given the lack of specific therapeutic drugs, further research on an effective combined intervention approach remains necessary.

Raghunathan R, Turajane K, Wong LC, 2022, Biomarkers in Neurodegenerative Diseases: Proteomics Spotlight on ALS and Parkinson’s Disease. International Journal of Molecular Sciences, 23(16): 9299.

Yun Y, Ha Y, 2020, CRISPR/Cas9-Mediated Gene Correction to Understand ALS. International Journal of Molecular Sciences, 21(11): 3801.

Ustyantseva EI, Medvedev SP, Zakian SM, 2020, Studying ALS: Current Approaches, Effect on Potential Treatment Strategy. Advances in Experimental Medicine and Biology, 2020(1241): 195–217.

Geronimo A, Albertson RM, Noto J, et al., 2022, Ten Years of Riluzole Use in a Tertiary ALS Clinic. Muscle & Nerve, 65(6): 659–666.

Witzel S, Maier A, Steinbach R, et al., 2022, Safety and Effectiveness of Long-term Intravenous Administration of Edaravone for Treatment of Patients with Amyotrophic Lateral Sclerosis. JAMA Neurology, 79(2): 121–130.

Hurwitz N, Radakovic R, Boyce E, et al., 2021, Prevalence of Pain in Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-analysis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 22(7–8): 449–458.

Kolbasi EN, Acikbas E, Aksimsek GP, et al., 2022, Validity and Reliability of the Turkish Version of “the Dyspnea-ALS-Scale (DALS-15)”. Neurological Sciences, 43(3): 1823–1829.

Halliday V, Zarotti N, Coates E, et al., 2021, Delivery of Nutritional Management Services to People with Amyotrophic Lateral Sclerosis (ALS). Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 22(5–6): 350–359.

Abati E, Manini A, Comi GP, et al., 2022, Inhibition of Myostatin and Related Signaling Pathways for the Treatment of Muscle Atrophy in Motor Neuron Diseases. Cellular and Molecular Life Sciences, 79(7): 374.

Al-Chalabi A, Hardiman O, 2013, The Epidemiology of ALS: A Conspiracy of Genes, Environment and Time. Nature Reviews Neurology, 9(11): 617–628.

Sears SM, Hewett SJ, 2021, Influence of Glutamate and GABA Transport on Brain Excitatory/Inhibitory Balance. Experimental Biology and Medicine (Maywood), 246(9): 1069–1083.

Sarlo GL, Holton KF, 2021, Brain Concentrations of Glutamate and GABA in Human Epilepsy: A Review. Seizure, 2021(91): 213–227.

Duman RS, Sanacora G, Krystal JH, 2019, Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron, 102(1): 75–90.

Song J, Yang X, Zhang M, et al., 2021, Glutamate Metabolism in Mitochondria is Closely Related to Alzheimer’s Disease. Journal of Alzheimer’s Disease, 84(2): 557–578.

Iovino L, Tremblay ME, Civiero L, 2020, Glutamate-induced Excitotoxicity in Parkinson’s Disease: The Role of Glial Cells. Journal of Pharmacological Sciences, 144(3): 151–164.

Boyko M, Gruenbaum SE, Gruenbaum BF, et al., 2014, Brain to Blood Glutamate Scavenging as a Novel Therapeutic Modality: A Review. Journal of Neural Transmission (Vienna), 121(8): 971–979.

Lapin B, Mate K, Li Y, et al., 2022, Subjective Health Perception Prioritizes Psychological Well-being over Physical Function in Advanced ALS: A Multigroup Structural Equation Modeling Analysis. Journal of the Neurological Sciences, 2022(442): 120442.

Considine J, Eastwood K, Webster H, et al., 2022, Family Presence during Adult resuscitation from Cardiac Arrest: A Systematic Review. Resuscitation, 7(180): 11–23.