CRCardiovascular Reviews3083-48802981-8109Bio-Byword Scientific Publishing Pty. Ltd.10.26689/cr.v3i1.10034ArticleAdvances in the Study of Magnetocardiography in Cardiovascular Diseaseshttps://artdesignp.com/journal/CR/3/1/10.26689/cr.v3i1.10034WangWenlong,WangLina,CuiJianguo,WangDong2025312025-04-02Cardiovascular diseases (CVDs) are one of the leading reasons for death and disability in patients worldwide. Their accurate diagnosis and assessment remain a considerable challenge in clinical settings. Magnetocardiography is a non-invasive, non-radioactive, and non-contact functional test. This examination has made significant progress in diagnosing and treating CVDs recently. However, most healthcare professionals are not aware of this new examination tool. In this review, we will summarize the development history and working principle of magnetocardiography, highlight its use in diagnosing, evaluating, and monitoring CVD treatment effects, and discuss the prospects for its application in clinical settings.

Roth GA, Forouzanfar MH, Moran AE, et al., 2015, Demographic and Epidemiologic Drivers of Global Cardiovascular Mortality. The New England Journal of Medicine, 372(14): 1333–1341.

Zhao D, Liu J, Wang M, et al., 2019, Epidemiology of Cardiovascular Disease in China: Current Features and Implications. Nature Reviews Cardiology, 16(4): 203–212.

Writing Committee of the Report on Cardiovascular Health and Diseases in China, 2022, Report on Cardiovascular Health and Diseases in China 2021: An Updated Summary. Biomedical and Environmental Sciences, 35(7): 573–603.

Roth BJ, 2023, Biomagnetism: The First Sixty Years. Sensors (Basel), 23(9): 4218.

Brisinda D, Fenici P, Fenici R, 2023, Clinical Magnetocardiography: The Unshielded Bet—Past, Present, and Future. Frontiers in Cardiovascular Medicine, 10: 1232882.

Wacker-Gussmann A, Strasburger JF, Wakai RT, 2022, Contribution of Fetal Magnetocardiography to Diagnosis, Risk Assessment, and Treatment of Fetal Arrhythmia. Journal of the American Heart Association, 11(15): e025224.

Her AY, Dischl D, Kim YH, et al., 2023, Magnetocardiography for the Detection of Myocardial Ischemia. Frontiers in Cardiovascular Medicine, 10: 1242215.

Shin ES, Chung JH, Park SG, et al., 2019, Comparison of Exercise Electrocardiography and Magnetocardiography for Detection of Coronary Artery Disease Using ST-Segment Fluctuation Score. Clinical Hemorheology Microcirculatory, 73(2): 283–291.

Alday EA, Ni H, Zhang C, et al., 2016, Comparison of Electric- and Magnetic-Cardiograms Produced by Myocardial Ischemia in Models of the Human Ventricle and Torso. PLoS One, 11(8): e0160999.

Kwon H, Kim K, Lee YH, et al., 2010, Non-Invasive Magnetocardiography for the Early Diagnosis of Coronary Artery Disease in Patients Presenting with Acute Chest Pain. Circulation Journal, 74(7): 1424–1430.

Kyoon LH, Kim K, Lee YH, et al., 2009, Detection of Non-ST-Elevation Myocardial Infarction Using Magnetocardiogram: New Information from Spatiotemporal Electrical Activation Map. Annals in Medicine, 41(7): 533–546.

Leeuwen PV, Hailer B, Lange S, et al., 2006, Identification of Patients with Coronary Artery Disease Using Magnetocardiographic Signal Analysis. Biomedicine Technology (Berl), 51(2): 83–88.

Arruda-Olson AM, Juracan EM, Mahoney DW, et al., 2002, Prognostic Value of Exercise Echocardiography in 5,798 Patients: Is There a Gender Difference?. Journal of American College of Cardiology, 39(4): 625–631.

Hailer B, Leeuwen PV, Chaikovsky I, et al., 2005, The Value of Magnetocardiography in the Course of Coronary Intervention. Ann Noninvasive Electrocardiology, 10(2): 188–196.

Gdowski MA, Murthy VL, Doering M, et al., 2020, Association of Isolated Coronary Microvascular Dysfunction with Mortality and Major Adverse Cardiac Events: A Systematic Review and Meta-Analysis of Aggregate Data. Journal of American of Heart Association, 9(9): e014954.

Kunadian V, Chieffo A, Camici PG, et al., 2020, An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group. European Heart Journal, 41(37): 3504–3520.

Zhu C, Miao L, Wei K, et al., 2024, Coronary Microvascular Dysfunction. Microvascular Research, 153: 104652.

Moshage W, Achenbach S, Göhl K, et al., 1991, Biomagnetic Localization of Ventricular Arrhythmias. Radiology, 180(3): 685–692.

Nakai K, Kawazoe K, Izumoto H, et al., 2005, Construction of a Three-Dimensional Outline of the Heart and Conduction Pathway by Means of a 64-Channel Magnetocardiogram in Patients with Atrial Flutter and Fibrillation. International Journal of Cardiovascular Imaging, 21(5): 555–561.

Nakai K, Oka T, Okabayashi H, et al., 2008, Three-Dimensional Spectral Map of Atrial Fibrillation by a 64-Channel Magnetocardiogram. Journal of Electrocardiology, 41(2): 123–130.

Sato Y, Yoshida K, Ogata K, et al., 2012, An Increase in Right Atrial Magnetic Strength is a Novel Predictor of Recurrence of Atrial Fibrillation After Radiofrequency Catheter Ablation. Circulation Journal, 76(7): 1601–1608.

Kandori A, Miyashita T, Ogata K, et al., 2006, Magnetocardiography Study on Ventricular Depolarization-Current Pattern in Patients with Brugada Syndrome and Complete Right-Bundle Branch Blocks. Pacing Clinical Electrophysiology, 29(12): 1359–1367.

Fung G, Luo H, Qiu Y, et al., 2016, Myocarditis. Circulation Research, 118(3): 496–514.

Pille M, Gapelyuk A, Berg K, et al., 2023, Cardiac Magnetic Field Map Topology Quantified by Kullback-Leibler Entropy Identifies Patients with Clinically Suspected Myocarditis. Frontiers of Cardiovascular Medicine, 10: 1276321.

Brala D, Thevathasan T, Grahl S, et al., 2023, Application of Magnetocardiography to Screen for Inflammatory Cardiomyopathy and Monitor Treatment Response. Journal of American Heart Association, 12(4): e027619.

Morales S, Corsi MC, Fourcault W, et al., 2017, Magnetocardiography Measurements with ⁴He Vector Optically Pumped Magnetometers at Room Temperature. Physics Medicine Biology, 62(18): 7267–7279.

Dang HB, Maloof AC, Romalis MV, 2010, Ultrahigh Sensitivity Magnetic Field and Magnetization Measurements with an Atomic Magnetometer. Applied Physics Letters, 97: 227.

Shah VK, Wakai RT, 2013, A Compact, High Performance Atomic Magnetometer for Biomedical Applications. Physics Medicine Biology, 58(22): 8153–8161.

Yang Y, Xu M, Liang A, et al., 2021, A New Wearable Multichannel Magnetocardiogram System with a SERF Atomic Magnetometer Array. Science Report, 11(1): 5564.

Tao R, Zhang S, Wang Y, et al., 2022, MCG-Net: End-to-End Fine-Grained Delineation and Diagnostic Classification of Cardiac Events from Magnetocardiographs. IEEE Journal of Biomedicine Health Information, 26(3): 1057–1067.

Pena ME, Pearson CL, Goulet MP, et al., 2020, A 90-Second Magnetocardiogram Using a Novel Analysis System to Assess for Coronary Artery Stenosis in Emergency Department Observation Unit Chest Pain Patients. International Journal of Cardiology Heart Vascular, 26: 100466.