DHDermatological Health3083-47752981-8206Bio-Byword Scientific Publishing Pty. Ltd.10.26689/dh.v3i2.11136ArticleReal-World Study on Adverse Reactions to Technetium (Tc99m) Medronate Based on VigiAccess Database Mininghttps://artdesignp.com/journal/DH/3/2/10.26689/dh.v3i2.11136LiuWeigang,WuQian,TangHeqing2025322025-07-11Objective: This study aims to explore adverse events related to Technetium (Tc99m) Medronate using the VigiAccess database, uncover potential risk signals, and provide comprehensive reference for rational clinical drug use to ensure patient safety. Methods: The study retrieved adverse event reports related to Technetium (Tc99m) Medronate from the VigiAccess database, preprocessed the data, and employed the Reporting Odds Ratio (ROR) method to detect signals and analyze the characteristics and intensity of adverse events. Results: A total of 543 adverse event reports related to Technetium (Tc99m) Medronate were retrieved. The data showed that reports from female patients accounted for 48.62%, higher than the 26.15% from male patients, and the 18–64 age group had a higher proportion of reports at 52.89%. In terms of adverse event distribution, skin and subcutaneous tissue disorders accounted for 24.12%, general disorders and administration site conditions accounted for 21.68%, and nervous system disorders accounted for 14.83%. These three types of disorders were the most common adverse reactions during the use of Technetium (Tc99m) Medronate. Further ROR analysis revealed strong associations between Technetium (Tc99m) Medronate and adverse events such as product efficacy issues, vasodilation, and decreased therapeutic response. The ROR value for product efficacy issues was as high as 379.29 (95% CI: 180.18, 798.47), vasodilation was 60.75 (95% CI: 45.91, 80.51), and decreased therapeutic response was 36.35 (95% CI: 20.48, 64.81). Conclusion: This study analyzed adverse events related to Technetium (Tc99m) Medronate using the VigiAccess database, finding that female patients and the age group of 18 to 64 had a higher proportion. The related adverse events were mainly concentrated in skin and subcutaneous tissue disorders, general disorders and administration site conditions, and nervous system disorders. Adverse events such as product efficacy issues, vasodilation, and decreased therapeutic response were strongly associated with Technetium (Tc99m) Medronate, indicating the need for special attention to these adverse reactions in clinical use, strengthening drug monitoring and management to ensure patient safety, and providing important reference for clinicians in the rational use of Technetium (Tc99m) Medronate.

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