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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">erd</journal-id><journal-title-group><journal-title>Education Reform and Development</journal-title></journal-title-group><issn>2652-5364</issn><eissn>2652-5372</eissn><publisher><publisher-name>Bio-Byword Scientific Publishing Pty. Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26689/erd.v8i2.14186</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>Practical Strategies and Application Exploration of Virtual Simulation Experiment Teaching for Biochemistry in Colleges and Universities</title><url>https://artdesignp.com/journal/erd/8/2/10.26689/erd.v8i2.14186</url><author>ZhaoRuihong,WangMengdi,LiJing,YinXinming,HeJinhuan</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>8</volume><issue>2</issue><history><date date-type="pub"><published-time>2026-03-11</published-time></date></history><abstract>This paper explores the concept of virtual simulation experiment teaching, and based on the current situation and existing problems of biochemical experimental teaching in colleges and universities, puts forward effective improvement strategies. The purpose is to exert the educational practical value, empower students’ career development, and fundamentally enhance their comprehensive quality and core competitiveness. Empowering higher education with digital technologies and promoting the modernization and digital transformation of biochemical experimental education in universities, virtual simulation experiment teaching is worthy of in-depth exploration and practice.</abstract><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>Li J, Zhang JF, Zhang C, et al., 2023, Application of Virtual Simulation Experiment “Determination of Michaelis Constant” in Experimental Teaching. Laboratory Science, 26(06): 87–92.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B2" content-type="article"><label>2</label><element-citation publication-type="journal"><p>He P, Yu JN, Sun Y, et al., 2023, Led by Science and Technology, Forging First-Class Courses: Development and Construction of Virtual Simulation Experiment Course of Biochemistry and Molecular Biology. Journal of Biology Teaching in Universities (Electronic Edition), 13(06): 8–12.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B3" content-type="article"><label>3</label><element-citation publication-type="journal"><p>Bai P, Ji SM, Yang SY, et al., 2022, Exploration on the Integration of Open Experiment and Virtual Simulation Experiment in the Teaching of Clinical Biochemistry Inspection Technology. Science and Technology Vision, (26): 60–62.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B4" content-type="article"><label>4</label><element-citation publication-type="journal"><p>Wang YF, Liu Y, Zhao GX, et al., 2022, Design and Practice of Outcome-Oriented Virtual Simulation Experiment for Pathogenic Microorganism Detection of Clinical Samples. Journal of Microbiology, 42(04): 117–122.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B5" content-type="article"><label>5</label><element-citation publication-type="journal"><p>Zeng FC, 2022, Application and Exploration of Virtual Simulation Experiment in the Teaching of “Automotive Aerodynamics”. Science and Technology and Innovation, (14): 31–33 + 37.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B6" content-type="article"><label>6</label><element-citation publication-type="journal"><p>Wang Z, 2022, Virtual Simulation Experiment Based on MOE Software: Molecular Docking of Donepezil and Acetylcholinesterase. Chemistry Education (Chinese and English), 43(04): 107–111.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B7" content-type="article"><label>7</label><element-citation publication-type="journal"><p>He JC, Zhou ZR, Yan WL, et al., 2021, Application Exploration of Virtual Simulation “Second Classroom” in the Teaching Reform of Sanitary Chemistry. Guangdong Chemical Industry, 48(21): 211–212.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B8" content-type="article"><label>8</label><element-citation publication-type="journal"><p>Ding N, Yu XL, 2021, Research on the Application of Virtual Simulation Experiment in the Course of Food Nutrition and Hygiene. Continuing Medical Education, 35(10): 38–40.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B9" content-type="article"><label>9</label><element-citation publication-type="journal"><p>Zhang XL, Hou LJ, Zhang XY, et al., 2021, Application and Exploration of Virtual Simulation Experiment in the Experimental Teaching of Clinical Biochemistry Inspection. Journal of Hebei North University (Natural Science Edition), 37(08): 46–48 + 51.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B10" content-type="article"><label>10</label><element-citation publication-type="journal"><p>Li L, Zhang TT, Xie K, 2021, Design and Development of EEG Detection and Analysis Virtual Simulation Experiment Project Based on Unity3D. Chinese Journal of Medical Physics, 38(05): 631–637.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B11" content-type="article"><label>11</label><element-citation publication-type="journal"><p>Liu Y, Deng M, 2020, Design, Production and Application of Morphology Virtual Simulation Experiment Integrating Basic and Clinical Medicine. Journal of Nanjing Medical University (Social Sciences Edition), 20(04): 389–392.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B12" content-type="article"><label>12</label><element-citation publication-type="journal"><p>Xu SY, Hu RP, Yuan H, et al., 2020, Biochemistry Virtual Simulation Experiment Empowers the Cultivation of Innovative Ability of Outstanding Doctors. Health Vocational Education, 38(09): 106–108.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B13" content-type="article"><label>13</label><element-citation publication-type="journal"><p>Medical Department of Shanghai Jiao Tong University, 2020, Virtual Simulation Experiment of “Protein Expression, Purification and Structural Analysis” Launched by the Medical Department of Shanghai Jiao Tong University. Clinical Research, 28(05): 119.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B14" content-type="article"><label>14</label><element-citation publication-type="journal"><p>Lu XJ, Luo J, Zhang H, 2018, Design and Exploration of the Virtual Simulation Experiment Process of Transgenic Mice Combining Virtual and Real Teaching. Modern Vocational Education, (35): 239.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B15" content-type="article"><label>15</label><element-citation publication-type="journal"><p>Wei CH, Li JX, Li XJ, et al., 2018, Exploration on the Teaching Reform of Experimental Technology in “Medical Biochemistry and Molecular Biology”. Journal of Medical Teaching in Universities (Electronic Edition), 8(06): 34–37.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
