JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v10i2.14136ArticleObservation on the Efficacy of Non-Invasive Positive Pressure Ventilation in Respiratory Support Treatment for Severe Pneumoniahttps://artdesignp.com/journal/JCNR/10/2/10.26689/jcnr.v10i2.14136LiuBaoshan20261022026-03-11Objective: To evaluate the efficacy of noninvasive positive pressure ventilation (NIPPV) in respiratory support for severe pneumonia. Methods: Data were analyzed from 74 patients with severe pneumonia undergoing respiratory support at our hospital between May 2024 and April 2025. Patients were randomly assigned using a random number table to two groups (n = 37 each): the experimental group received NIPPV, while the control group underwent conventional invasive mechanical ventilation. Intergroup differences were compared. Results: Compared with the control group, the experimental group demonstrated significantly higher PaO2 and oxygenation index, significantly lower PaCO2, significantly reduced levels of WBC, CRP, and PCT, significantly higher overall efficacy rate, and significantly lower incidence of adverse reactions after treatment (p < 0.05). Pre-treatment PaO2, oxygenation index, PaCO2, WBC, CRP, and PCT levels showed no significant differences between groups (p > 0.05). Conclusion: Non-invasive positive pressure ventilation demonstrates favorable outcomes in respiratory support for severe pneumonia.

Ma L, Liu G, Li Y, 2025, A Study on Noninvasive Positive Pressure Mechanical Ventilation Combined with Nasal High-Flow Oxygen Therapy for Severe Pneumonia with Respiratory Failure. Clinical Research, 33(10): 33–36.

Cui L, Zhang W, Liu S, 2025, Effects of Nebulized Ipratropium Bromide Combined with Non-Invasive Positive Pressure Ventilation on Oxygenation Status, APACHE II Score, and MODS Score in Patients with Severe Pneumonia and Respiratory Failure. Heilongjiang Medical Science, 48(8): 105–106.

Jin Y, Liu Y, Feng H, 2025, Efficacy Analysis of Nasal High-Flow Oxygen Therapy Combined with Non-Invasive Positive Pressure Ventilation in Elderly Patients with Severe Pneumonia and Respiratory Failure. Chinese and Foreign Medical Research, 23(15): 27–30.

Liu X, Chen L, Chen M, 2025, Effect of BiPAP on Disease Control and Respiratory Function in Neonates with Severe Pneumonia. Medical Equipment, 38(3): 89–91 + 94.

Lü C, Chen S, 2025, Application of Risk Warning Intervention in ICU Patients with Severe Pneumonia Undergoing BiPAP. Medical Equipment, 38(3): 157–160.

Yuan G, Chen W, 2024, Clinical Outcomes of Alternating Nasal High-Flow Oxygen Therapy and Non-Invasive Positive Pressure Ventilation in Elderly Patients with Severe Pneumonia and Respiratory Failure. Clinical Medical Research and Practice, 9(29): 63–66.

Zhao M, Song P, Wang Y, et al., 2024, Clinical Efficacy Study of “Alternating Mode of Non-Invasive Positive Pressure Ventilation + Ventilator Oxygen Therapy” in Elderly Patients with Severe Pneumonia and Respiratory Failure. Trauma and Critical Care Medicine, 12(2): 74–78.

Wang L, 2023, Comparative Efficacy of Warmed Humidified High-Flow Nasal Cannula Oxygen Therapy versus Non-Invasive Positive Pressure Ventilation in Patients with Severe Pneumonia and Type I Respiratory Failure. Chinese Journal of Public Health, 35(23): 165–167.

Song J, Wang N, Wang T, et al., 2023, Efficacy and Safety of High-Flow Oxygen Therapy Combined with Non-Invasive Positive Pressure Ventilation in Elderly Patients with Severe Pneumonia and Respiratory Failure. Contemporary Chinese Medicine, 30(17): 44–48.