JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v10i2.14152ArticleApplication of Allergen Subcutaneous Immunotherapy in Patients with Allergic Rhinitishttps://artdesignp.com/journal/JCNR/10/2/10.26689/jcnr.v10i2.14152YangXiaorong,BaiBingyue,PengZhiquan,ZhouNa,JiangTingting20261022026-03-11Objective: To analyze the efficacy of allergen subcutaneous injection immunotherapy in patients with allergic rhinitis. Methods: Fifty patients with allergic rhinitis admitted from May 2023 to May 2025 were selected as study subjects and randomly divided into a control group and an observation group, with 25 patients in each group. The control group was treated with budesonide nasal spray, while the observation group received allergen subcutaneous injection immunotherapy in addition to the control treatment. The treatment efficacy, adverse reactions, symptom improvement time, and immune indicators were compared between the two groups. Results: The observation group showed a higher disease treatment efficacy than the control group (p < 0.05); the incidence of adverse reactions in the observation group was not statistically significant compared to the control group (p > 0.05); the observation group had a shorter symptom improvement time for nasal obstruction, rhinorrhea, and sneezing than the control group (p < 0.05); before treatment, there was no statistical significance in immune indicators between the two groups (p > 0.05); after treatment, CD3+ and CD4/CD8+ in the observation group were higher than those in the control group (p < 0.05). Conclusion: Allergen subcutaneous injection immunotherapy in patients with allergic rhinitis can improve disease treatment efficacy, alleviate clinical symptoms, and enhance immune function. This therapy is safe and has clinical application value.

Wang A, Gao N, Shi C, 2025, Study on the Effects of Sublingual Specific Immunotherapy Combined with Nasal Spray on Rhinitis Symptoms and Lund-Kennedy Nasal Endoscopy Scores in Patients with Allergic Rhinitis. Jilin Medical Journal, 46(10): 2439–2442.

Xiong W, Lei S, Huang X, et al., 2025, The Application Effect of Sublingual Immunotherapy in Children with Allergic Rhinitis Combined with Chronic Sinusitis. Contemporary Medicine and Pharmacy, 32(26): 83–87.

Guan M, Wang S, Kang F, et al., 2025, Study on the Efficacy of Subcutaneous Specific Immunotherapy in Patients with Allergic Rhinitis and Observation of Its Correlation with Nasal Exhaled Nitric Oxide (NO) Concentration. Chinese Journal of Otorhinolaryngology Integrating Traditional and Western Medicine, 33(04): 272–278.

Yang Y, Chen H, Huang N, et al., 2025, Safety and Efficacy of Cluster Immunotherapy with House Dust Mite and House Dust Mite/Dust Mite Allergens for Allergic Rhinitis. Chinese Journal of Clinical Immunology and Allergy, 19(01): 18–25.

Chen L, Jiang H, Long Y, et al., 2025, The Impact of Sublingual Specific Immunotherapy on Clinical Efficacy and Exhaled Nitric Oxide Levels in Patients with Allergic Rhinitis. Modern Medicine and Health, 41(03): 612–615.

Wang P, 2025, Analysis of the Efficacy of Sublingual Immunotherapy with Dust Mite Drops in Patients with Allergic Rhinitis of Different Age Groups. China Medical Science, 15(04): 131–134.

Zhao R, Hu W, Cheng J, et al., 2024, The Evaluation Value of MLR in Assessing the Short-Term Efficacy of Sublingual Immunotherapy in Children with Allergic Rhinitis. Journal of Molecular Diagnosis and Treatment, 16(12): 2377–2380, 2385.

Wu H, Zhou S, Zhang X, 2024, Efficacy Analysis of Sublingual Immunotherapy for Children with Allergic Rhinitis Accompanied by Epistaxis. Heilongjiang Medical and Pharmaceutical Sciences, 47(06): 10–12.

Wang Q, Li L, Yin J, et al., 2024, Retrospective Analysis of Systemic Anaphylaxis Caused by Allergen Subcutaneous Immunotherapy. Chinese Journal of Clinical Immunology and Allergy, 18(04): 370–375.

Wang Q, Liu J, Zhi F, et al., 2024, Expert Consensus on Nursing Care for Subcutaneous Injection in Allergen-Specific Immunotherapy. Chinese Journal of Nursing, 59(09): 1080–1084.