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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">JCNR</journal-id><journal-title-group><journal-title>Journal of Clinical and Nursing Research</journal-title></journal-title-group><issn>2208-3685</issn><eissn>2208-3693</eissn><publisher><publisher-name>Bio-Byword Scientific Publishing Pty. Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26689/jcnr.v10i2.14166</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>Liu Shaowu’s “Exterior Region” Theory and Clinical Cases of Treating Cold-Damp Type Allergic Rhinitis with Ephedra-Based “Diaphoresis Method”</title><url>https://artdesignp.com/journal/JCNR/10/2/10.26689/jcnr.v10i2.14166</url><author>JiHuixia,LiuXiaoxu,LiuGao</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>10</volume><issue>2</issue><history><date date-type="pub"><published-time>2026-03-11</published-time></date></history><abstract>Based on Liu Shaowu’s “Exterior Region” theory in the “Three Regions and Six Diseases” doctrine, combined with Zhang Zhongjing’s therapeutic principle of “diaphoresis method”, this paper explores the TCM pathogenesis and treatment methods of cold-damp type allergic rhinitis. It points out that the core pathogenesis of the disease is the invasion of wind-cold-damp pathogens into the exterior region, leading to stagnation of defensive Yang and obstruction of orifices and collaterals. Through three typical clinical cases (involving symptoms such as nasal itching, nasopharyngeal tube obstruction, nasal congestion with headache), modified ephedra-based formulas such as Mahuang Decoction, Maxing Shigan Decoction, and Xiaoqinglong Decoction are used, combined with drugs for inducing resuscitation, resolving dampness, and promoting blood circulation, to expel pathogens through diaphoresis. Clinical observations show that expelling pathogens with the “diaphoresis method” can effectively relieve symptoms with significant curative effect. This study provides new ideas and methods for expanding the application of the “diaphoresis method” in the treatment of sinusitis.</abstract><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>Ma W, 2011, Liu Shaowu’s Lectures on Three Regions and Six Diseases. Beijing: Science Press: 5–6 + 8.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B2" content-type="article"><label>2</label><element-citation publication-type="journal"><p>Tian D, 2005, Huangdi Neijing Suwen. Beijing: People’s Medical Publishing House: 13, 63.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B3" content-type="article"><label>3</label><element-citation publication-type="journal"><p>Yang S, Bai Q, Wang S, 2022, Application of Zhang Zhongjing’s “Diaphoresis Method” in the Treatment of Skin Diseases. Journal of Western Traditional Chinese Medicine, 2022(3): 64–67.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B4" content-type="article"><label>4</label><element-citation publication-type="journal"><p>Zhang Z, 2017, Notes on Medication by National Medical Master Zhang Zhiyuan. Beijing: China Medical Science and Technology Press: 71.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B5" content-type="article"><label>5</label><element-citation publication-type="journal"><p>Xie S, Xu Y, Tang J, 2024, Clinical Application of Herba Ephedrae and Ramulus Cinnamomi in Treating Respiratory Diseases. World Traditional Chinese Medicine, 19(14): 2191–2195.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B6" content-type="article"><label>6</label><element-citation publication-type="journal"><p>Zhao J, 1986, Experience in Treating Tinnitus. Journal of Yunnan College of Traditional Chinese Medicine, 1986(4): 37–40.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B7" content-type="article"><label>7</label><element-citation publication-type="journal"><p>Liu X, 2006, Revised Integration of Chinese and Western Medicine in Medical Practice. Beijing: People’s Medical Publishing House: 19.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
