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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">JCNR</journal-id><journal-title-group><journal-title>Journal of Clinical and Nursing Research</journal-title></journal-title-group><issn>2208-3685</issn><eissn>2208-3693</eissn><publisher><publisher-name>Bio-Byword Scientific Publishing Pty. Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26689/jcnr.v10i3.14410</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>Advances in Mechanisms and Clinical Applications of Lasers with Different Wavelengths in Medicine</title><url>https://artdesignp.com/journal/JCNR/10/3/10.26689/jcnr.v10i3.14410</url><author>YuRongzhu,FengLiwei,GuoJing,BuXiaolin</author><pub-date pub-type="publication-year"><year>2026</year></pub-date><volume>10</volume><issue>3</issue><history><date date-type="pub"><published-time>2026-04-05</published-time></date></history><abstract>Since its inception, laser technology has undergone a leapfrog development from fundamental exploration to extensive clinical applications. In its early stages, lasers were mainly used for simple tissue cutting. With continuous technological innovation, their clinical value in precision therapy and minimally invasive intervention has become increasingly prominent. Lasers have evolved into an indispensable tool for the treatment of numerous diseases, driving a paradigm shift in diagnosis and treatment within the medical field. Lasers of different wavelengths exhibit significant differences in penetration depth and absorption characteristics within biological tissues. This wavelength selectivity enables lasers to act precisely on target tissues while minimizing damage to surrounding normal tissues. For instance, specific wavelengths can be selectively absorbed by chromophores such as melanin and hemoglobin, thereby achieving precise treatment of related diseases. This constitutes the fundamental mechanism underlying the precision of medical lasers. This review aims to systematically summarize recent advances in the working principles, expanded clinical applications, and cutting-edge research trends of various wavelengths of lasers in medicine. It is intended to provide comprehensive and up-to-date references for researchers and clinicians in related fields, and to promote the further development and application of medical laser technology.</abstract><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>Kasai K, 2017, Picosecond Laser Treatment for Tattoos and Benign Cutaneous Pigmented Lesions. Laser Therapy, 26(4): 274–281.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B2" content-type="article"><label>2</label><element-citation publication-type="journal"><p>Jung D, Seung N, Seo S, et al., 2024, Skin Rejuvenation through Topical Application of Indocyanine Green with Diffractive Optical Element Mode of 785 nm Picosecond Laser in Asian Females. Journal of Cosmetic Dermatology, 23(7): 2411–2419.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B3" content-type="article"><label>3</label><element-citation publication-type="journal"><p>Dogra V, Chinni B, Valluru K, et al., 2013, Multispectral Photoacoustic Imaging of Prostate Cancer: Preliminary Ex-vivo Results. Journal of Clinical Imaging Science, 3: 41.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B4" content-type="article"><label>4</label><element-citation publication-type="journal"><p>Kuehlmann B, Stern-Buchbinder Z, Wan D, et al., 2019, Beneath the Surface: A Review of Laser Remodeling of Hypertrophic Scars and Burns. Advances in Wound Care, 8(4): 168–176.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B5" content-type="article"><label>5</label><element-citation publication-type="journal"><p>Gonçalves A, Monteiro F, Brantuas S, et al., 2025, Clinical and Preclinical Evidence on the Bioeffects and Movement-Related Implications of Photobiomodulation in Orthodontic Tooth Movement: A Systematic Review. Orthodontics and Craniofacial Research, 28(1): 12–53.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B6" content-type="article"><label>6</label><element-citation publication-type="journal"><p>Venugopalan V, Nishioka N, Mikić B, 1995, The Thermodynamic Response of Soft Biological Tissues to Pulsed Ultraviolet Laser Irradiation. Biophysical Journal, 69(4): 1259–1271.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B7" content-type="article"><label>7</label><element-citation publication-type="journal"><p>Shortt A, Allan B, Evans J, 2013, Laser-Assisted In-Situ Keratomileusis versus Photorefractive Keratectomy for Myopia. Cochrane Database of Systematic Reviews, 2013(1): CD005135.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B8" content-type="article"><label>8</label><element-citation publication-type="journal"><p>Wang J, Cheng B, 2010, Effects of Medium-Wave Ultraviolet Radiation on the Expression of Certain Marker Molecules in Cultured Skin Stem Cells In Vitro. Chinese Journal of Dermatology, 43(10): 726–729.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B9" content-type="article"><label>9</label><element-citation publication-type="journal"><p>Ash C, Dubec M, Donne K, et al., 2017, Effect of Wavelength and Beam Width on Penetration in Light-Tissue Interaction Using Computational Methods. Lasers in Medical Science, 32(8): 1909–1918.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B10" content-type="article"><label>10</label><element-citation publication-type="journal"><p>Boergen K, Birngruber R, Gabel V, et al., 1977, Selective Coagulation of Small Vessels by Means of Argon Laser: Intravital Microscopic Studies. Berichte der Deutschen Ophthalmologischen Gesellschaft, 74: 428–434.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B11" content-type="article"><label>11</label><element-citation publication-type="journal"><p>Allison R, Moghissi K, 2013, Photodynamic Therapy Mechanisms. Clinical Endoscopy, 46(1): 24–29.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B12" content-type="article"><label>12</label><element-citation publication-type="journal"><p>Henderson T, 2024, Infrared Light Penetration Principles, Practices, and Limitations. Frontiers in Neurology, 15: 1398894.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B13" content-type="article"><label>13</label><element-citation publication-type="journal"><p>Cecchetti D, Bauer E, Guerriero E, et al., 2022, Comparative Treatments of a Green Tattoo Ink with Ruby and Nd:YAG Nano- and Picosecond Lasers in Normal and Array Mode. Scientific Reports, 12(1): 3571.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B14" content-type="article"><label>14</label><element-citation publication-type="journal"><p>Wu X, Wang X, Shang Y, et al., 2021, Beneficial Effects of Treatment with Low-Fluence 755-nm Q-Switched Alexandrite Laser for Nevus of Ota. Lasers in Surgery and Medicine, 53(10): 1364–1369.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B15" content-type="article"><label>15</label><element-citation publication-type="journal"><p>Kauvar A, Sun R, Bhawan J, et al., 2022, Treatment of Facial and Non-Facial Lentigines with a 730 nm Picosecond Titanium-Sapphire Laser is Safe and Effective. Lasers in Surgery and Medicine, 54(1): 89–97.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B16" content-type="article"><label>16</label><element-citation publication-type="journal"><p>Shi Y, Jiang W, Li W, et al., 2021, Comparison of Fractionated Frequency-Doubled 1064/532 nm Picosecond Nd:YAG Lasers and Non-Ablative Fractional 1540 nm Er:Glass in Treatment of Facial Atrophic Scars: A Randomized Split-Face Double-Blind Trial. Annals of Translational Medicine, 9(10): 862.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B17" content-type="article"><label>17</label><element-citation publication-type="journal"><p>Jacques S, 2013, Optical Properties of Biological Tissues: A Review. Physics in Medicine and Biology, 58(11): R37–R61.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B18" content-type="article"><label>18</label><element-citation publication-type="journal"><p>Al-Hadidi N, Griffith J, Al-Jamal M, et al., 2015, Role of Recipient-Site Preparation Techniques and Post-Operative Wound Dressing in Surgical Management of Vitiligo. Journal of Cutaneous and Aesthetic Surgery, 8(2): 79–87.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B19" content-type="article"><label>19</label><element-citation publication-type="journal"><p>da Silva T, Ribeiro R, Mencalha A, et al., 2023, Photobiomodulation at Molecular, Cellular, and Systemic Levels. Lasers in Medical Science, 38(1): 136.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B20" content-type="article"><label>20</label><element-citation publication-type="journal"><p>Artzi O, Friedman O, Al-Niaimi F, et al., 2020, Mitigation of Postsurgical Scars Using Lasers: A Review. Plastic and Reconstructive Surgery Global Open, 8(4): e2746.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B21" content-type="article"><label>21</label><element-citation publication-type="journal"><p>Ge Y, Pan H, Zhao J, et al., 2023, Burn and Wound Repair-Related Research. Chinese Journal of Burns and Wound Repair, 39(1): 53–58.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B22" content-type="article"><label>22</label><element-citation publication-type="journal"><p>Yang Z, Yang Z, Zuo Z, 2024, Early Intervention of Carbon Dioxide Fractional Laser in Hypertrophic Scar through TGFβ-1/Smad3 Signaling Pathway. Lasers in Medical Science, 39(1): 78.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B23" content-type="article"><label>23</label><element-citation publication-type="journal"><p>Naess E, Molvik T, Ludwig D, et al., 2002, Computer-Assisted Laser Photocoagulation of the Retina: A Hybrid Tracking Approach. Journal of Biomedical Optics, 7(2): 179–189.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B24" content-type="article"><label>24</label><element-citation publication-type="journal"><p>Gawęcki M, 2019, Micropulse Laser Treatment of Retinal Diseases. Journal of Clinical Medicine, 8(2): 242.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B25" content-type="article"><label>25</label><element-citation publication-type="journal"><p>Luttrull J, Dorin G, 2012, Subthreshold Diode Micropulse Laser Photocoagulation as Invisible Retinal Phototherapy for Diabetic Macular Edema: A Review. Current Diabetes Reviews, 8(4): 274–284.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B26" content-type="article"><label>26</label><element-citation publication-type="journal"><p>Liang H, Liang L, Yu Y, et al., 2020, Thermal Effect of Holmium Laser during Ureteroscopic Lithotripsy. BMC Urology, 20(1): 69.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
