JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v10i7.15891ArticleClinical Study on Xinhuanglong Decoction in Treating Severe Pneumonia with Qi-Yin Deficiency Syndrome Based on the Theory of “Lung and Large Intestine Being Interrelated”https://artdesignp.com/journal/JCNR/10/7/10.26689/jcnr.v10i7.15891WangXiaoyan20261072026-07-31Guided by the TCM theory of “the lung and large intestine are interrelated”, this paper analyzes severe pneumonia with Qi-Yin deficiency syndrome. Combined with the connotation of Zang-Fu viscera correlation theory and modern research on lung-intestine correlation, it sorts out the core pathogenesis of simultaneous lung and intestinal disease complicated with deficiency of both Qi and unobstructed Fu Qi in this disease, and elaborates the formula logic and clinical application value of Xinhuanglong Decoction for replenishing Qi and nourishing Yin, unblocking Fu organs and clearing heat. Most patients with severe pneumonia are accompanied by varying degrees of gastrointestinal injury and severe systemic inflammatory response. The elderly and patients with chronic illnesses and physical weakness are more prone to develop a complicated pathogenesis of intermingled deficiency and excess. With simultaneous purgation and tonification, Xinhuanglong Decoction can effectively improve gastrointestinal motility and reduce the level of inflammatory indicators, shorten the duration of mechanical ventilation and ICU hospitalization, and is more suitable for elderly and chronically ill patients with severe pneumonia of Qi-Yin deficiency syndrome. This prescription embodies the TCM diagnosis and treatment idea of simultaneous treatment of lung and intestine, possesses high clinical application potential, and can provide references for integrated traditional Chinese and Western medicine treatment of severe pneumonia, worthy of further verification and promotion through large-sample clinical studies.

Wang P, Gong Z, Shi Y, et al., 2025, Effects of Xuanbai ChengQi Decoction Based on “Simultaneous Lung-Intestine Treatment” on TLRs Expression and Inflammatory Response in Lung and Intestine Tissues of Sepsis Mice. World Journal of Integrated Traditional and Western Medicine, 20(12): 2383–2390.

Ren J, Liu J, Ma Y, 2025, Clinical Study on Xinhuanglong Decoction Combined with Western Medicine in Treating Severe Acute Organophosphorus Poisoning of Toxin-Heat Accumulation Type. Journal of Wannan Medical College, 44(3): 254–257 + 262.

Wang Z, 2025, Discussion on the Influence of Acupuncture on Severe Pneumonia Sepsis Patients Complicated with Acute Gastrointestinal Injury Based on the Gut-Lung Axis, thesis, Beijing University of Chinese Medicine.

Sun Y, Zhao J, Zhang R, 2025, Exploration on Theoretical Connotation and Clinical Application of “The Lung and Large Intestine Are Interior-Exterior Related”. Clinical Journal of Chinese Medicine, 17(12): 109–114.

Wang S, Zhang Q, Wu Y, 2024, Analysis of TCM Syndrome Elements of Severe Pneumonia Complicated with Acute Gastrointestinal Injury. Emergency Journal of Traditional Chinese Medicine, 33(12): 2110–2114.

Li S, Li Z, Wang S, et al., 2026, Xinhuanglong Decoction for Cancerous Intestinal Obstruction of Qi-Yin Deficiency Type. Acta Chinese Medicine, 1–6.

Huang J, Wang H, Liu J, et al., 2024, Exploration on Treating Severe Pneumonia Starting from the Intestine. Emergency Journal of Traditional Chinese Medicine, 33(7): 1186–1189 + 1192.

Li N, Yao F, Ye D, 2024, Research Progress on Application of Weijing Decoction in Lung Diseases. World Journal of Traditional Chinese Medicine, 19(3): 426–431 + 436.

Wang T, Deng Y, Sun X, 2024, Randomized Controlled Study of Gualou Dahuang Decoction in Treating Severe Pneumonia. Chinese Journal of Integrated Traditional and Western Medicine, 44(4): 407–413.

Xu B, 2023, Clinical Efficacy of Xuanfei Tongfu Decoction as Adjuvant Therapy for Middle-Aged and Elderly Severe Pneumonia Complicated with Gastrointestinal Dysfunction. Inner Mongolia Journal of Traditional Chinese Medicine, 42(10): 26–27.

He J, Mao Z, Song P, 2022, Clinical Study of Modified Xuanbai ChengQi Decoction in Treating Severe Pneumonia Complicated with Acute Gastrointestinal Injury. Journal of Nanjing University of Chinese Medicine, 38(2): 103–108.

Li Z, Lai F, Zhang Y, 2020, Exploration on Application Ideas of Xinhuanglong Decoction in Critical Illness Treatment. Jiangsu Journal of Traditional Chinese Medicine, 52(6): 77–80.

Miao Q, Liu Q, Xing J, 2019, Observation on Efficacy of Xinhuanglong Decoction in Treating ICU Sepsis Patients with Gastrointestinal Dysfunction. Modern Doctor of China, 57(32): 123–126.

Ma J, Ouyang W, 2017, Clinical Observation of Huanglong Decoction in Treating Elderly Severe Pneumonia Complicated with Toxic Paralytic Ileus. Hebei Journal of Traditional Chinese Medicine, 39(1): 70–72.

Zhang Y, Hao J, Guo P, 2017, Efficacy Observation of Integrated Traditional and Western Medicine Treatment Based on “The Lung and Large Intestine Are Interior-Exterior Related” in Children with Severe Pneumonia. Emergency Journal of Traditional Chinese Medicine, 26(3): 487–490.