JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v1i2.111Articlehttps://artdesignp.com/journal/JCNR/1/2/10.26689/jcnr.v1i2.111Devi. GAruna2021122021-07-30Context: Nurses play a vital role in the management of poisoning,as it demands close observation, timely administration of antidotes in adequate doses and skilful nursing interventions. Methods:Quasi experimental design- A historical comparison was adopted.Total 30 organophosphorus compound poisoning patients, out of which 15 participants were in experimental group and 15 participants were in control group. Purposive sampling technique was used to select the participants admitted in Dhanvantri Critical Care Centre at Erode. The level of respiratory parameters were assessed by adopting in vitro ABG (Arterial Blood Gas) analysis which constitutes pH (acidity), pCO2 (partial pressure of carbon dioxide), pO2 (partial pressure of oxygen) and HCO3 (bicarbonate). Serum cholinesterase estimation level was measured from the vein by adopting in vitro method.