JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v1i3.160Articlehttps://artdesignp.com/journal/JCNR/1/3/10.26689/jcnr.v1i3.160GuilingHuang2017132017-11-30Esophagus cancer is a common malignant tumor in China, and itsprevalence rate and fatality rate are the highest in the world whoseoccurrence is related to multiple factors, including family heredity,race, gender, region, diet and so on. Esophagus cancer is the diseasewith the most Chinese characteristic. The pathogenesis of esophagus cancer is very complicated, and the epigenetics in the pathogenetic process has become the current research hotspot, and the reversible feature provides a new direction for the early screening, prevention and treatment of esophagus cancer. DNA methylation is the most deep epigenetics in the current study, and the pattern of genome methylation is often abnormal in the cancerization of esophagus cancer. The folate, as the methyl group donor, and B-vitamins related to one-carbon metabolism, shall directly influence the condition of DNA methylation, give rise to the change of epigenetics, affect the occurrence of esophagus cancer. This paper summarizes the relationship among the occurrence of esophagus cancer and folate, several kinds of B-vitamins related to one-carbon metabolism, DNA methylation.