JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v2i1.275Articlehttps://artdesignp.com/journal/JCNR/2/1/10.26689/jcnr.v2i1.275tingJiang Ting2018212018-01-31Objective: Objective: To evaluate the applications of dexmedetomidine given composite dezocine spinal anesthesia in patients undergoing total hip replacement surgery. Methods: 120 cases ASA Ⅰ ~ Ⅱ grade elective surgery THA patients were divided into group A (n=40), group B (n=40), C group (n=40) from June 2015 to June 2016.Group A were routined with endotracheal intubation operation；Group B were gap into the line L 2-3 spinal anesthesia, anesthesia after a fixed pumping 0.2 mg dezocine a mixture of 3 ml ； Group C were threatmented with dextrose infusion 3μg Mi Ding mixture 3.5 ml. The levels of mean arterialpressure (MAP ), heart rate (HR), oxygen saturation (SPO 2 ), end-tidal carbon dioxide (PETCO 2 ) and other hemodynamic parameters and plasma epinephrine (E), norepinephrine (NE), malondialdehyde (MDA) of three groups before and after 10 min of anesthesia 5min(T 0 ), of anesthesia (T 1 ), at the start of surgery (T 2 ), 1 Xiaoshi (T 3 ) after completion of anesthesia, the end of the surgery (T 4 ).The anesthetic complications occur of three groups were compared. Results: The levels of MAP, HR, SPO 2 , PETCO 2 , E, NE, MDA in T 1 ~ T 4 time were increased than T 0 stage (P<0.05).The levels of MAP, HR, SPO 2 , PETCO 2 , E, NE, MDA in T 1 ~ T 4 time of Groups A were increased than Groups B，Group C (P<0.05).The levels of MAP, HR, SPO 2 , PETCO 2 , E, NE, MDA in T 1 ~ T 4 time of Groups A and Groups B were compared. The cognitive disorders, nausea, vomiting, restlessness, chills, a high incidence of respiratory depression of Group A were higher than Group B, Group C (P<0.05),will high incidence of respiratory depression of Group B were higher than Groups C (P<0.05). Conclusion: dexmedetomidine given composite dezocine spinal anesthesia can effectively stabilize hemodynamics THA patients and reduce patient stress and blood vessels, its low incidence of postoperative complications, worthy of promotion application.