JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v2i4.410ArticleObservation of Stereotactic Radiosurgery (Cyberknife) on Hepatocellular Carcinoma with Portal Vein Tumor Thrombosishttps://artdesignp.com/journal/JCNR/2/4/10.26689/jcnr.v2i4.410TangYang2018242018-10-12The purpose of the study was to analyze the clinical effect of stereotactic radiosurgery (SRS) (Cyberknife) on hepatocellular carcinoma with portal vein tumor thrombosis (HCC-PVTT). Data from 50 patients with HCC-PVTT who received Cyberknife from August 2013 to April 2016 was collected for efficacy analysis. Moreover, survival correlation was evaluated by Cox proportionalhazards model. The total effective rate in 1–3 months after treatment was 64.00%, including 7 cases in complete remission, 12 cases in partial remission, 13 cases in stable conditions, and 18 cases with enlargement; a 4–24-months follow-up (with an average of 11.58 ± 2.58 months) showed that median survival, 1-year cumulative survival rate, and 2-year cumulative survival rate were, respectively, 11.86 ± 1.79 months, 48.00%, and 20.00%. Moreover, the Cox proportional-hazards model indicates that it was with no correlation between lesion diameter, classification of liver function, pre-operative alphafetoprotein, types of hepatitis, number of tumors, ascites, types of tumor emboli, total dose, and survival rate. SRS is effective for HCC-PVTT and serves as an ideal treatment clinically to help preserve patients’ lives, which is worthy of clinical promotion and application.

Liyu, Liu Xiaoliang, Zhang Sujing, et.al. Observation of Stereotactic Radiosurgery (SRS) on 30 cases of advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis (HCC-PVTT) [C]// Clinical Seminar by Chinese Journal of Histochemistry and Cytochemistry. 2017,25(2):25-26.

Wan Zhiqing, Duan Xuezhang. Efficacy and Safety of Stereotactic Radiotherapy for Primary Liver Cancer [J]. Eletronic Journal of Liver Tumor, 2016, 3(3):7-12.

Zhang Tao, Sunjing, He Weiping, et. al. Efficacy of Stereotactic Radiosurgery for Small Hepatocellular Carcinoma [J]. Journal of Clinical Hepatology, 2017, 33(4):694-698.

Cheng Tao. Observation of Stereotactic Radiosurgery (SRS) on Small Hepatocellular Carcinoma [J]. Journal of Imaging Research and Medical Applications, 017, 1(10):41-42.

Xu Ruisha, Yu Shuyong, Xu Xiaojiang, et.al. Efficacy of Stereotactic Radiotherapy with Cyberknife for the Treatment of Liver Metastases from Colorectal Cancer [J]. Progress in Modern Biomedicine, 2017, 17(4):684-687.

Li Huan, Sun Jing, Zhang Tao et.al. Efficacy and Prognosis of Cyberknife in Treatment of Recurrent Hepatocellular Carcinoma [J]. Journal of Clinical Hepatology, 2017,14(12):2337-2341.

Li Yu, Zhang Sujing, Liu Xiaoliang et.al. Observation of Stereotactic Radiotherapy for 50 Cases of Early Primary Liver Cancer [J]. Journal of Chinese Oncology, 2016, 22(1):49-52.

Gao Yunhong, Wang Mancang, Zhang Yiping. Preliminary Analysis of Cyberknife efficacy in Ttreatment of Primary Lung Cancer [J]. China Continuing Medical Education, 2016, 8(12):64-65.