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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">JCNR</journal-id><journal-title-group><journal-title>Journal of Clinical and Nursing Research</journal-title></journal-title-group><issn>2208-3685</issn><eissn>2208-3693</eissn><publisher><publisher-name>Bio-Byword Scientific Publishing Pty. Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26689/jcnr.v6i1.2934</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>Exploring the Treatment of Coronary Artery Atherosclerosis from the Direction of Inflammatory Vesicles with Wind-Extinguishing and Phlegm-Resolving Medicine</title><url>https://artdesignp.com/journal/JCNR/6/1/10.26689/jcnr.v6i1.2934</url><author>ZhaoBing,GongLihong</author><pub-date pub-type="publication-year"><year>2022</year></pub-date><volume>6</volume><issue>1</issue><history><date date-type="pub"><published-time>2022-01-19</published-time></date></history><abstract>Atherosclerosis is a fundamental pathological change in coronary heart disease, with vulnerable plaque formation leading to decreased plaque stability and plaque rupture, and is a major cause of acute cardiovascular events. The inflammatory response is an important mechanism in the development and progression of atherosclerosis, and plaque stability is closely related to the inflammatory response. In recent years, the role of NLRP3 inflammatory vesicles, which are involved in macrophage foaminess, in the inflammatory response to atherosclerosis has received increasing attention. Chinese medicine is able to modulate inflammatory vesicles to improve atherosclerotic plaque stability, showing good promise in the prevention and treatment of atherosclerotic vulnerable plaques. Based on the role of inflammatory vesicles in atherosclerosis and the results of previous studies that wind-extinguishing and phlegm-resolving medicine can effectively modulate the inflammatory response to intervene in the treatment of atherosclerosis, this paper aims to investigate the treatment of coronary atherosclerosis by wind-extinguishing and phlegm-resolving medicine from the direction of inflammatory vesicles.</abstract><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>Zhao L, Gong L, 2017, The Clinical Efficacy of Compound Wenban Decoction Combined with External Counterpulsation on Patients with Unstable Angina Pectoris of Coronary Heart Disease and the Effect on Serum Nitric Oxide and Vascular Endothelin-1. Integrated Chinese and Western Medicine Journal of Cerebrovascular Diseases, 15(18): 2228-2231.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B2" content-type="article"><label>2</label><element-citation publication-type="journal"><p>Zhao D, Gong L, Xiao F, 2018, The Effect of Wenban Decoction Containing Serum on the Expression of Macrophage Foaming Autophagy-Related Proteins LC3B and Beclin 1. Journal of Traditional Chinese Medicine, 59(11): 978- 982.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B3" content-type="article"><label>3</label><element-citation publication-type="journal"><p>Zhang S, Gong L, Ni X, et al., 2015, Effect of Wind-Extinguishing and Phlegm-Resolving Medicinal Compound on the Expression of Beclin-1 and Bcl-2 Genes in Atherosclerotic Vulnerable Plaques of AopE Gene Knockout Mice. Chinese Journal of Traditional Chinese Medicine, 33(9): 2151-2153.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B4" content-type="article"><label>4</label><element-citation publication-type="journal"><p>Wolf D, Ley K, 2019, Immunity and Inflammation in Atherosclerosis.Circ Res, 124(2): 315-327.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B5" content-type="article"><label>5</label><element-citation publication-type="journal"><p>Ridker PM, Everett BM, Thuren T, et al., 2017, Antiinflammation Therapy with Canakinumab for Atherosclerotic Disease. N EngI J Med, 377(12): 1119-1131.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B6" content-type="article"><label>6</label><element-citation publication-type="journal"><p>Liu W, Yin Y, Zhou Z, et al., 2014, OxLDL-Induced IL-1 Beta Secretion Promoting foam Cells Formation was Mainly via CD36 Mediated ROS Production Leading to NLRP3 Inflammasome Activation. Inflamm Res, 63(1):33-43.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B7" content-type="article"><label>7</label><element-citation publication-type="journal"><p>Lamkanfi M, Dixit VM, 2014, Mechanisms and Functions of Inflammasomes. Cell, 157(5): 1013-1022.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B8" content-type="article"><label>8</label><element-citation publication-type="journal"><p>Yan Y, Jiang W, Liu L, et al., 2015, Dopamine Controls Systemic Inflammation Through Inhibition of NLRP3 Inflammasome. Cell, 160: 62-73.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B9" content-type="article"><label>9</label><element-citation publication-type="journal"><p>Volt H, García JA, Doerrier C, et al., 2016, Same Molecule but Different Expression: Aging and Sepsis Trigger NLRP3 Inflammasome Activation, a Target of Melatonin. J Pineal Res, 60(2): 193-205.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B10" content-type="article"><label>10</label><element-citation publication-type="journal"><p>Zhou R, Yazdi AS, Menu P, et al., 2011, A Role for Mitochondria in NLRP3 Inflammasome Activation. Nature, 469: 221-225.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B11" content-type="article"><label>11</label><element-citation publication-type="journal"><p>He D, Wang H, Xu L, et al., 2016, Saikosaponin-A Attenuates Oxidized LDL Uptake and Prompts Cholesterol Efflux in THP-1 Cells. J Cardiovasc Pharmacol, 67(6): 510 -518.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B12" content-type="article"><label>12</label><element-citation publication-type="journal"><p>Satoh M, Tabuchi T, Itoh T, et al., 2014, NLRP3 Inflammasome Activation in Coronary Artery Disease: Results from Prospective and Randomized Study of Treatment with Atorvastatin or Rosuvastatin. Clinical Science, 126(3-4): 233-241.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B13" content-type="article"><label>13</label><element-citation publication-type="journal"><p>Zheng F, Xing S, Gong Z, et al., 2014, Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-deficient Mice. Mediators of Inflammation, 2014: 1-8?</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B14" content-type="article"><label>14</label><element-citation publication-type="journal"><p>Ehsan M, Singh KK, Lovren F, et al., 2016, Adiponectin Limits Monocytic Microparticle-Induced Endothelial Activation by Modulation of the AMPK, Akt and NF?B Signaling Pathways. Atherosclerosis, 245: 1-11.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B15" content-type="article"><label>15</label><element-citation publication-type="journal"><p>Cardiovascular Branch of Chinese Society of Traditional Chinese Medicine, 2018, Expert Consensus on Diagnosis and Treatment of Stable Angina Pectoris in Coronary Heart Disease. Journal of Traditional Chinese Medicine, 59(5): 447-450.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B16" content-type="article"><label>16</label><element-citation publication-type="journal"><p>Yan X, Gong L, 2019, Treating Coronary Heart Disease from the Perspective of the “Deficiency-Phlegm-Stasis-Toxin (Heat)-Wind” Event Chain. Journal of Integrated Traditional Chinese and Western Medicine Cardio-Cerebrovascular Disease, 17(13): 1985-1987.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B17" content-type="article"><label>17</label><element-citation publication-type="journal"><p>Guo Q, 2012, Professor Gong Lihong’s Experience in Treating Unstable Angina Pectoris based on Wind Phlegm Theory. Shenyang: Liaoning University of Traditional Chinese Medicine.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B18" content-type="article"><label>18</label><element-citation publication-type="journal"><p>Nourooz-Zadeh J, Smith CC, Betteridge DJ, 2001, Measures of Oxidative Stress in Heterozygous Familial Hypercholesterolaemia. Atherosclerosis, 156(2): 435-441.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B19" content-type="article"><label>19</label><element-citation publication-type="journal"><p>Chi Y, Gong L, 2015, Effect of Wind-Extinguishing and Phlegm-Resolving Medicinal Compound on the Expression of HO-1 and PPAR? in Atherosclerotic Unstable Plaques of Apo E Gene Knockout Mice. Chinese Emergency in Traditional Chinese Medicine, 24(1): 4-6.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B20" content-type="article"><label>20</label><element-citation publication-type="journal"><p>Jiang M, Gong L, 2015, Effect of Wenban Decoction on TLR4 mRNA in Atherosclerotic Unstable Plaques of ApoE Knockout Mice. Journal of Traditional Chinese Medicine, 56(7): 598-601.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B21" content-type="article"><label>21</label><element-citation publication-type="journal"><p>Ding Y, Gong L, Gao F, et al., 2010, The Effect of Chinese Herbal Medicine for Seeking Wind and Expelling Phlegm on the Expression of NF-kB mRNA and ET-1 mRNA in Human Umbilical Vein Endothelial Cells Induced by Ang ?. Integrated Traditional Chinese and Western Medicine Disease Journal, 8(12): 1479-1481.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B22" content-type="article"><label>22</label><element-citation publication-type="journal"><p>Ni X, Gong L, Zhang S, et al., 2016, The Effect of Wind-Extinguishing and Phlegm-Resolving Medicinal on the Autophagy-Related Proteins Beclin1 and LC3 of Atherosclerotic Unstable Plaque in ApoE Gene Knockout Mice. Chinese and Western Medicine Combined Cardio-Cerebrovascular Disease, 14(05): 488-491.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B23" content-type="article"><label>23</label><element-citation publication-type="journal"><p>An Y, Gong L, Wei W, 2014, The Effect of Wind-Searching and Expectorating Method on Inflammatory Response and PPAR? Gene Expression in Aortic Vulnerable Plaques of ApoE Gene Knockout Mice. Chinese Emergency in Traditional Chinese Medicine, 23(09): 1591-1593+1609.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B24" content-type="article"><label>24</label><element-citation publication-type="journal"><p>Han J, Pan XY, Xu Y, et al., 2012, Curcumin Induces Autophagy to Protect Vascular Endothelial Cell Survival from Oxidative Stress Damage. Autophagy, 8(5): 812-825?</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B25" content-type="article"><label>25</label><element-citation publication-type="journal"><p>Guo Q, 2012, Professor Gong Lihong’s Experience in Treating Unstable Angina Pectoris based on Wind Phlegm Theory. Shenyang: Liaoning University of Traditional Chinese Medicine.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B26" content-type="article"><label>26</label><element-citation publication-type="journal"><p>Cheng X, Gong L, Li N, et al., 2016, Effect of Wenban Decoction on the Methylation of Plasma Thrombomodulin Gene Promoter in Patients with Acute Coronary Syndrome with Phlegm and Blood Stasis Syndrome. Journal of Traditional Chinese Medicine, 57(2): 140-144.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B27" content-type="article"><label>27</label><element-citation publication-type="journal"><p>Han X, Xu X, Shen Q, et al., 1996, Research on the Separation and Purification of Scorpion Toxin IV. Journal of Henan Medical University, (03): 1-4.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B28" content-type="article"><label>28</label><element-citation publication-type="journal"><p>Zou J, 2010, Extraction and Isolation of Centipede Polypeptide and Study on Its Analgesic Activity. Hubei University of Traditional Chinese Medicine.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B29" content-type="article"><label>29</label><element-citation publication-type="journal"><p>Tuesday Fu, 2014, The Modern Pharmacology and Common Clinical Compatibility Analysis of Dilong. China Modern Medicine, 8(03): 238-239.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B30" content-type="article"><label>30</label><element-citation publication-type="journal"><p>Xiong Y, Fang Y, Han Y, et al., 2018, Research Progress in the Pharmacological Effects of Tangerine. Chinese Patent Medicine, 40(09): 2030-2033.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B31" content-type="article"><label>31</label><element-citation publication-type="journal"><p>Yang L, Zhou Y, Wang X, et al., 2021, Research Progress on the Influence of Processing on the Chemical Constituents and Pharmacological Effects of Pinellia Ternata. Journal of Liaoning University of Traditional Chinese Medicine. 1-13.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B32" content-type="article"><label>32</label><element-citation publication-type="journal"><p>Zuo J, Zhang J, Hu X, 2021, Research Progress on the Chemical Constituents and Modern Pharmacological Effects of Atractylodes Macrocephala. Journal of Liaoning University of Traditional Chinese Medicine. 1-8.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B33" content-type="article"><label>33</label><element-citation publication-type="journal"><p>Nie Y, Shen L, He J, et al., 2014, Observation on the Effect of Leech Extract on Inflammation of Rat Epithelial Tissue. China Health Industry, 11(09): 24-26.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B34" content-type="article"><label>34</label><element-citation publication-type="journal"><p>Chen N, Jia L, Song N, et al., 2019, Effect of Huatan Quyu Recipe on Lipid Deposition in the Liver of Atherosclerotic Rabbits. Journal of Traditional Chinese Medicine, 60(20): 1755-1759.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B35" content-type="article"><label>35</label><element-citation publication-type="journal"><p>Liang W, 2018, Study on the Efficacy and Mechanism of Fufang Qima Capsule in Improving Carotid Artery Intimal Thickening. Guangzhou: Guangzhou University of Traditional Chinese Medicine.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B36" content-type="article"><label>36</label><element-citation publication-type="journal"><p>Jiang S, 2019, Anti-Atherosclerosis Effect and Mechanism of Smilax China. Hubei University of Traditional Chinese Medicine, Wuhan.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B37" content-type="article"><label>37</label><element-citation publication-type="journal"><p>Zhang Y, Si Q, Wang X, 2005, Experimental Study of Centipede Against Atherosclerosis in Rabbits. Pharmacology and Clinics of Chinese Materia Medica, 21(1): 26-27.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B38" content-type="article"><label>38</label><element-citation publication-type="journal"><p>Sun Y, Huang X, Liang W, et al., 2018, Effects of Dried Tangerine Peel and Pinellia on PI3K-Akt Pathway, SOD, MDA, SA-?-gal Levels in Atherosclerotic Mice. Journal of Capital Medical University, 39(6): 805-809.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B39" content-type="article"><label>39</label><element-citation publication-type="journal"><p>Chen J, 2019, Protective Efect of Chuanpisu on LPS-Induced RAW 264.7 Cell Damage. Modern Food Science and Technology, 35(10): 44-49.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B40" content-type="article"><label>40</label><element-citation publication-type="journal"><p>Yao W, Xin Z, Wang YS, et al., 2014, An Extract from Medical Leech Improve the Function of Endothelial Cells In Vitro and Attenuates Atherosclerosis in ApoE Null Mice by Reducing Macrophages in the Lesions. Biochemical and Biophysical Research Communications, 455(2): 119-125.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
