JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v6i3.3757ArticleTh17 Cells and Tregs in HTLV-1 Infectionhttps://artdesignp.com/journal/JCNR/6/3/10.26689/jcnr.v6i3.3757Nafiseh Saghafi,ElhamAbdollahi,MofradMalihe Hasanzadeh2022632022-05-19HTLV-1 (human T-lymphotropic virus type 1) causes chronic infection of human T lymphocytes. HTLV-1 infection is known to be related to multiple diseases, including neoplastic growth of HTLV-1-infected T cells (ATL) and neoplastic inflammatory conditions, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), Sjögren’s syndrome with arthritis, polymyositis uveitis, and bronchoalveolitis. Regulatory T cells (Tregs) regulate inflammatory cells, such as Th17 cells. The purpose of this study was to evaluate Tregs and Th17 cells, as well as the expression of related transcription factors (ROR-?t and FOXP3) and cytokines (IL-10, TGF-?, IL-6, and IL-17A) in HTLV-1 infection.

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