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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">JCNR</journal-id><journal-title-group><journal-title>Journal of Clinical and Nursing Research</journal-title></journal-title-group><issn>2208-3685</issn><eissn>2208-3693</eissn><publisher><publisher-name>Bio-Byword Scientific Publishing Pty. Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26689/jcnr.v6i3.3907</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>Diseases of the Respiratory Tract: Asthma and Chronic Obstructive Pulmonary Disease</title><url>https://artdesignp.com/journal/JCNR/6/3/10.26689/jcnr.v6i3.3907</url><author>TonySara M,AbdelrahimMohamed EA</author><pub-date pub-type="publication-year"><year>2022</year></pub-date><volume>6</volume><issue>3</issue><history><date date-type="pub"><published-time>2022-05-31</published-time></date></history><abstract>Short acting beta2-agonists (SABAs) such as salbutamol and terbutaline are commonly used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). According to the guideline produced by the British Thoracic Society (BTS) and the Scottish Intercollegiate Guidelines Network (SIGN), SABAs are considered to be the first line of treatment in asthma management. The National Institute for Health and Clinical Excellence (NICE) guidelines also recommend the use of SABA as the first line of treatment for managing patients with COPD. The recommendations in NICE guidelines state that in COPD patients, breathlessness and exercise limitation should be first medicated with short-acting bronchodilators (including beta2-agonists or anticholinergics) when it is required. Both salbutamol and terbutaline have been widely used for asthma and COPD, and they have been found to be extremely beneficial in the two pathologic conditions.</abstract><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>British Thoracic Society, 2007, British Guideline on the Management of Asthma. Thorax, 58 Suppl I, 1-98.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B2" content-type="article"><label>2</label><element-citation publication-type="journal"><p>Pauwels RA, Buist AS, Calverley PMA, et al., 2001, Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop Summary. Am J Respir Crit Care Med, 163(5): 1256-1276.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B3" content-type="article"><label>3</label><element-citation publication-type="journal"><p>National Institute for Health and Clinical Excellence (NICE), 2004, Chronic Obstructive Pulmonary Disease: National Clinical Guideline for Management of Chronic Obstructive Pulmonary Disease in Adults in Primary and Secondary Care. Thorax, 1, 59. http://www.nice.org.uk/guidance/</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B4" content-type="article"><label>4</label><element-citation publication-type="journal"><p>Global Initiative for Chronic Obstructive Lung Disease (GOLD), 2007, Global Strategy for Diagnosis, Management, and Prevention of COPD. http://www.goldcopd.com</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B5" content-type="article"><label>5</label><element-citation publication-type="journal"><p>Yanai M, Sekizawa K, Ohrui T, et al., 1992, Site of Airway Obstruction in Pulmonary Disease: Direct Measurement of Intrabronchial Pressure. J Appl Physiol, 72(3): 1016-1023.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B6" content-type="article"><label>6</label><element-citation publication-type="journal"><p>Mead J, Turner JM, Macklem PT, et al., 1967, Significance of the Relationship between Lung Recoil and Maximum Expiratory Flow. J Appl Physiol, 22(1): 95-108.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B7" content-type="article"><label>7</label><element-citation publication-type="journal"><p>Jensen EJ, Dahl R, Steffensen F, 2000, Bronchial Reactivity to Cigarette Smoke; Relation to Lung Function, Respiratory Symptoms, Serum-Immunoglobulin E and Blood Eosinophil and Leukocyte Counts. Respir Med, 94(2): 119-127.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B8" content-type="article"><label>8</label><element-citation publication-type="journal"><p>Fletcher C, Peto R, 1977, The Natural History of Chronic Airflow Obstruction. Br Med J, 1(6077): 1645-1648.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B9" content-type="article"><label>9</label><element-citation publication-type="journal"><p>Hogg PJC, 2004, Pathophysiology of Airflow Limitation in Chronic Obstructive Pulmonary Disease. Lancet, 364(9435): 709-721.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B10" content-type="article"><label>10</label><element-citation publication-type="journal"><p>Retamales I, Elliott WM, Meshi B, et al., 2001, Amplification of Inflammation in Emphysema and Its Association with Latent Adenoviral Infection. Am J Respir Crit Care Med, 164(3): 469-473.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B11" content-type="article"><label>11</label><element-citation publication-type="journal"><p>Gorecka D, Gorzelak K, Sliwinski P, et al., 1997, Effect of Long-Term Oxygen Therapy on Survival in Patients with Chronic Obstructive Pulmonary Disease with Moderate Hypoxaemia. Thorax, 52(8): 674-679.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B12" content-type="article"><label>12</label><element-citation publication-type="journal"><p>Barnes PJ, 2000, Chronic Obstructive Pulmonary Disease. N Engl J Med, 343(4): 269-280.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B13" content-type="article"><label>13</label><element-citation publication-type="journal"><p>Petty TL, 1995, Enjoying Life with Chronic Obstructive Pulmonary Disease, Cedar Grove Laennec Publishing, NJ.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B14" content-type="article"><label>14</label><element-citation publication-type="journal"><p>Altman LC, Hill JS, Hairfield WM, et al., 1981, Effects of Corticosteroids on Eosinophil Chemotaxis and Adherence. J Clin Invest, 67(1): 28-36.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B15" content-type="article"><label>15</label><element-citation publication-type="journal"><p>Kesten S, Chapman KR, 1993, Physician Perceptions and Management of COPD. Chest, 104(1): 254-258.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B16" content-type="article"><label>16</label><element-citation publication-type="journal"><p>Dennis SM, Sharp SJ, Vickers MR, 2000, Regular Inhaled Salbutamol and Asthma Control: The TRUST Randomised Trial. Therapy Working Group of the National Asthma Task Force and the MRC General Practice Research Framework. Lancet, 355: 1675-1679.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B17" content-type="article"><label>17</label><element-citation publication-type="journal"><p>Walters EH, Walters J, Gibson P, et al., 2003, Inhaled Short Acting Beta2 Agonist Use in Asthma: Regular Versus As Needed Treatment. Cochrane Database Syst Rev, 2000(4): CD001285.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B18" content-type="article"><label>18</label><element-citation publication-type="journal"><p>Abdelrahim ME, Saeed H, Harb HS, et al., 2021, Essentials of Aerosol Therapy in Critically Ill Patients, Springer.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B19" content-type="article"><label>19</label><element-citation publication-type="journal"><p>Soiza RL, Myint PK, 2019, The Scottish Intercollegiate Guidelines Network (Sign) 157: Guidelines on Risk Reduction and Management of Delirium. Medicina, 55(8): 491.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B20" content-type="article"><label>20</label><element-citation publication-type="journal"><p>Adams NP, Bestall JC, Lasserson TJ, et al., 2005, Fluticasone Versus Placebo for Chronic Asthma in Adults and Children. Cochrane Database Syst Rev, 2005(4): CD003135.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B21" content-type="article"><label>21</label><element-citation publication-type="journal"><p>O’Byrne P, Barnes PJ, Rodriguez-Gomez G, et al., 2001, Low Dose Inhaled Budesonide and Formoterol in Mild Persistent Asthma: The OPTIMA Randomized Trial. Am J Respir Crit Care Med, 164: 1392-1397.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B22" content-type="article"><label>22</label><element-citation publication-type="journal"><p>Pauwels RA, Pedersen S, Busse WW, 2003, Early Intervention with Budesonide in Mild Persistent Asthma: A Randomised, Double-Blind Trial. Lancet, 361(9363): 1071-1076.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B23" content-type="article"><label>23</label><element-citation publication-type="journal"><p>Vogelberg C, Goldstein S, Graham L, et al., 2020, A Comparison of Tiotropium, Long-Acting ?2-Agonists and Leukotriene Receptor Antagonists on Lung Function and Exacerbations in Paediatric Patients with Asthma. Respiratory Research, 21(1): 1-19.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B24" content-type="article"><label>24</label><element-citation publication-type="journal"><p>Miwa N, Nagano T, Ohnishi H, et al., 2018, An Open-Label, Multi-Institutional, Randomized Study to Evaluate the Additive Effect of a Leukotriene Receptor Antagonist on Cough Score in Patients with Cough-Variant Asthma Being Treated with Inhaled Corticosteroids. Kobe Journal of Medical Sciences, 64(4): E134.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B25" content-type="article"><label>25</label><element-citation publication-type="journal"><p>Celli BR, MacNee W, Agusti A, et al., 2004, Standards for The Diagnosis and Treatment of Patients with COPD: A Summary of the ATS/ERS Position Paper. Eur Respir J, 23(6): 932-946.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B26" content-type="article"><label>26</label><element-citation publication-type="journal"><p>Nials AT, Ball DI, Butchers PR, et al., 1994, Formoterol on Airway Smooth Muscle and Human Lung Mast Cells: A Comparison with Salbutamol and Salmeterol. Eur J Pharmacol, 251(2-3): 127-135.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B27" content-type="article"><label>27</label><element-citation publication-type="journal"><p>Cazzola M, Marco FD, Santus P, et al., 2004, The Pharmacodynamic Effects of Single Inhaled Doses of Formoterol, Tiotropium and Their Combination in Patients with COPD. Pulm Pharmacol Ther, 17(1): 35-39.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B28" content-type="article"><label>28</label><element-citation publication-type="journal"><p>Cazzola M, Noschese P, Salzillo A, et al., 2005, Bronchodilator Response to Formoterol After Regular Tiotropium or to Tiotropium After Regular Formoterol in COPD Patients. Respir Med, 99(5): 524-528.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B29" content-type="article"><label>29</label><element-citation publication-type="journal"><p>van Noord JA, Aumann JL, Janssens E, et al., 2005, Comparison of Tiotropium Once Daily, Formoterol Twice Daily and Both Combined Once Daily in Patients with COPD. Eur Respir J, 26(2): 214-222.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B30" content-type="article"><label>30</label><element-citation publication-type="journal"><p>Poole PJ, Black PN, 2001, Oral Mucolytic Drugs for Exacerbations of Chronic Obstructive Pulmonary Disease: Systematic Review. BMJ, 322(7297): 1271.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B31" content-type="article"><label>31</label><element-citation publication-type="journal"><p>Stanescu D, Sanna A, Veritier C, et al., 1996, Airways Obstruction, Chronic Expectoration and Rapid Decline of FEV1 in Smokers Are Associated with Increased Levels of Sputum Neutrophils. Thorax, 51: 267-271.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B32" content-type="article"><label>32</label><element-citation publication-type="journal"><p>Tetley TD, 1993, New Perspectives on Basic Mechanisms in Lung Disease. 6. Proteinase Imbalance: Its Role in Lung Disease. Thorax, 48: 560-565.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B33" content-type="article"><label>33</label><element-citation publication-type="journal"><p>Repine JE, Bast A, Lankhorst I, 1997, Oxidative Stress in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med, 156: 341-357.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B34" content-type="article"><label>34</label><element-citation publication-type="journal"><p>Hunninghake GW, Crystal RG, 1983, Cigarette Smoking and Lung Destruction. Accumulation of Neutrophils in the Lungs of Cigarette Smokers. Am Rev Respir Dis, 128(5): 833-838.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B35" content-type="article"><label>35</label><element-citation publication-type="journal"><p>Keatings VM, Barnes PJ, 1997, Granulocyte Activation Markers in Induced Sputum: Comparison between Chronic Obstructive Pulmonary Disease, Asthma, and Normal Subjects. Am J Respir Crit Care Med, 155: 449-453.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B36" content-type="article"><label>36</label><element-citation publication-type="journal"><p>Keatings VM, Collins PD, Scott DM, et al., 1996, Differences in Interleukin-8 and Tumor Necrosis Factor-Alpha in Induced Sputum from Patients with Chronic Obstructive Pulmonary Disease or Asthma. Am J Respir Crit Care Med, 153: 530-534.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B37" content-type="article"><label>37</label><element-citation publication-type="journal"><p>Vestbo J, Sorensen T, Lange P, et al., 1999, Long-Term Effect of Inhaled Budesonide in Mild and Moderate Chronic Obstructive Pulmonary Disease: A Randomised Controlled Trial. Lancet, 353(9167): 1819-1823.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B38" content-type="article"><label>38</label><element-citation publication-type="journal"><p>Burge PS, Calverley PMA, Jones PW, et al., 2000, Randomised, Double Blind, Placebo Controlled Study of Fluticasone Propionate in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease: The ISOLDE Trial. BMJ, 320(7245): 1297.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B39" content-type="article"><label>39</label><element-citation publication-type="journal"><p>Calverley P, Pauwels R, Vestbo J, 2003, Combining Salmeterol and Fluticasone in the Treatment of Chronic Obstructive Pulmonary Disease. Lancet, 361: 449-456.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B40" content-type="article"><label>40</label><element-citation publication-type="journal"><p>Cazzola M, Dahl R, 2004, Inhaled Combination Therapy with Long-Acting {Beta}2-Agonists and Corticosteroids in Stable COPD. Chest, 126(1): 220-237.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B41" content-type="article"><label>41</label><element-citation publication-type="journal"><p>Szafranski W, Cukier A, Ramirez A, et al., 2003, Efficacy and Safety of Budesonide/Formoterol in the Management of Chronic Obstructive Pulmonary Disease. Eur Respir J, 21: 74-81.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B42" content-type="article"><label>42</label><element-citation publication-type="journal"><p>Barnes NC, Qiu Y-S, Pavord ID, et al., 2006, Antiinflammatory Effects of Salmeterol/Fluticasone Propionate in Chronic Obstructive Lung Disease. Am J Respir Crit Care Med, 173(7): 736-743.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B43" content-type="article"><label>43</label><element-citation publication-type="journal"><p>Sweetman CS, 2002, Martindale: The Complete Drug Reference, Pharmaceutical Press, London, 757-786.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B44" content-type="article"><label>44</label><element-citation publication-type="journal"><p>Theophilus A, Moore A, Prime D, et al., 2006, Co-Deposition of Salmeterol and Fluticasone Propionate by a Combination Inhaler. Int J Pharm, 313(1-2): 14-22.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B45" content-type="article"><label>45</label><element-citation publication-type="journal"><p>Eaton T, Lewis C, Young P, et al., 2004, Long-Term Oxygen Therapy Improves Health-Related Quality of Life. Respir Med, 98(4): 285-293.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B46" content-type="article"><label>46</label><element-citation publication-type="journal"><p>Elliott MW, Branthwaite MA, Steven MH, et al., 1990, Non-Invasive Mechanical Ventilation for Acute Respiratory Failure. BMJ, 300(6721): 358-360.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B47" content-type="article"><label>47</label><element-citation publication-type="journal"><p>Ambrosino N, Foglio K, Rubini F, et al., 1995, Non-Invasive Mechanical Ventilation in Acute Respiratory Failure Due to Chronic Obstructive Pulmonary Disease: Correlates for Success. Thorax, 50(7): 755-757.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B48" content-type="article"><label>48</label><element-citation publication-type="journal"><p>Brochard L, Lofaso F, Simonneau G, et al., 1995, Noninvasive Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease. N Engl J Med, 333(13): 817-822.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B49" content-type="article"><label>49</label><element-citation publication-type="journal"><p>Lightowler JV, Wedzicha JA, Elliott MW, et al., 2003, Non-Invasive Positive Pressure Ventilation to Treat Respiratory Failure Resulting from Exacerbations of Chronic Obstructive Pulmonary Disease: Cochrane Systematic Review and Meta-Analysis. BMJ, 326(7382): 185.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B50" content-type="article"><label>50</label><element-citation publication-type="journal"><p>Plant PK, Elliott MW, 1998, Non-Invasive Ventilation in Acute Exacerbations of COPD. QJM, 91(10): 657-660.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
