JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v6i4.4131ArticleResearch Progress on the Relationship Between Mitochondrial Dysfunction and Premature Ovarian Failure from the Perspective of TCM Treatmenthttps://artdesignp.com/journal/JCNR/6/4/10.26689/jcnr.v6i4.4131YanXiaoli,LiNan2022642022-07-28Premature ovarian failure (POF) is a prevalent yet challenging condition in gynecology. Its incidence rate has been steadily rising in recent years and is trending among younger age groups. The premature failure of ovarian function, which poses a serious threat to women’s physical and mental health, has emerged as a topic of concern in current research. At present, it is believed that the causes of premature ovarian failure are multifaceted, and its pathogenesis is complex, some of which are still not well-understood. Therefore, this article discusses the research progress of the pathogenesis of premature ovarian failure caused by mitochondrial dysfunction and serves as a reference for the prevention and further research of this condition from the perspective of traditional Chinese medicine treatment.

Jiao Z, Shi H, 2014, Advances in Diagnosis and Treatment of Premature Ovarian Failure. International Journal of Obstetrics and Gynecology, 2014(02): 108–111.

Li J, Xu L, Gao Y, 2021, Research Progress and Status Quo of the Etiology, Mechanism and Treatment of Premature Ovarian Failure. China Medical Science, 11(02): 58–61.

Huang X, Cao X, Lin N, et al., 2019, Evaluation and Revision of Chinese Medicine Diagnosis and Treatment Guidelines for Premature Ovarian Failure. Henan Traditional Chinese Medicine, 39(01): 82–86.

Sullivan SD, Castrillon DH, 2011, Insights into Primary Ovarian Insufficiency Through Genetically Engineered Mouse Models. Semin Reprod Med, 29(4): 283.

Jin M, Yu Y, Huang H, 2012, An Update on Primary Ovarian Insufficiency. Sci Chin Life Sci, 55(8): 677.

Wang LY, Wang DH, Zou XY, et al., 2009, Mitochondrial Functions on Oocytes and Preimplantation Embryos. Journal of Zhejiang University Science B, 10(7): 483–492.

Van Blerkom J, 2011, Mitochondrial Function in the Human Oocyte and Embryo and Their Role in Developmental Competence. Mitochondrion, 11(5): 797–813.

Jin M, Yu Y, Huang H, 2012, An Update on Primary Ovarian Insufficiency. Science China Life Sciences, 55(8): 677–686.

Tong C, 2018, Mitochondrial Abnormalities and Premature Ovarian Failure. Journal of Shandong University (Medical Edition), 56(04): 23–27.

Hu K, Liu H, Wan T, et al., 2010, The Relationship Between Mitochondria and Apoptosis. China Animal Husbandry and Veterinary Medicine, 377(12): 86–88.

Otten AB, Theunissen TE, Derhaag JG, et al., 2016, Differences in Strength and Timing of the mtDNA Bottleneck Between Zebrafish Germline and Non-Germline Cells. Cell reports, 16(3): 622–630.

Gorman GS, Chinnery PF, DiMauro S, et al., 2016, Mitochondrial Diseases. Nature Reviews Disease Primers, 2(1): 1–22.

Ropp PA, Copeland WC, 1996, Cloning and Characterization of the Human Mitochondrial DNA Polymerase, DNA Polymerase ?. Genomics, 36(3): 449–458.

Rahman S, Copeland WC, 2019, POLG-related Disorders and Their Urological Manifestations. Nat Rev Neurol, 15(1): 40–52?

Li H, Zhang Y, Lu L, et al., 2020, Reporting Quality of Polycystic Ovary Syndrome Practice Guidelines Based on the RIGHT Checklist. Medicine (Baltimore), 99(42): e22624. https://doi.org/10.1097/MD.0000000000022624

Qin Y, 2021, Research Progress of Antioxidants to Improve Ovarian Function. Chinese Journal of Reproductive Health, 32(01): 91–94.

Guo Y, 2017, Based on Mfn2 and Mitochondrial Membrane Potential to Explore the Effect of Kidney-Tonifying Traditional Chinese Medicine on the Outcome of IVF Patients with Kidney-Qi-Yin Deficiency. Shandong University of Traditional Chinese Medicine.

Kong D, Yao G, Sun Y, 2020, Research Progress of Mitochondrial Fusion Proteins Involved in Regulating Female Reproductive Function. Journal of Reproductive Medicine, 29(03): 402–406.

Bai G, 2016, The Expression of Mitochondrial Fusion Protein 2 in Ovarian Insufficiency and Its Correlation with the Pathogenesis. Huazhong University of Science and Technology.

Wang J, 2018, Xia Guicheng’s Experience in Treating Premature Ovarian Insufficiency from the Theory of “Heart-Kidney-Uterine Axis”. Journal of Traditional Chinese Medicine, 59(7): 554–557 + 576. https://doi.org/10.13288/j.11-2166/r.2018.07.004

Zhao X, Sun Y, Zhao H, et al., 2020, Improvement Effect of Zuogui Pill on Mitochondrial Function of Naturally Aging Mouse Oocytes. New Chinese Medicine and Clinical Pharmacology, 31(08): 924–929.

Zhao X, Wang L, Zhou F, 2019, Improvement Effect of Erxian Decoction on Mitochondria of Ovarian Granulosa Cells in Naturally Aging Mice. Chinese Materia Medica and Clinical, 35(04): 10–14.

Zhang Y, 2020, The Clinical Efficacy of Bushen Huoxue Recipe in Improving Ovarian Reserve and the Mechanism of Regulating Mitochondrial SIRT3. Nanjing University of Traditional Chinese Medicine.

Wang B, Gong Z, Song J, et al., 2020, Research Progress of SIRT1 Improving Ovarian Reserve by Inhibiting Oocyte Aging. International Journal of Reproductive Health/Family Planning, 39(01): 45–48 + 58.