The Efficacy and Safety of Dinoprostone Vaginal Insert for Labor Induction Following Optimization of Standard Operating Procedure: A Retrospective Study in China

JCNR

Journal of Clinical and Nursing Research

2208-36852208-3693

Bio-Byword Scientific Publishing Pty. Ltd.

10.26689/jcnr.v7i4.5053

Article

The Efficacy and Safety of Dinoprostone Vaginal Insert for Labor Induction Following Optimization of Standard Operating Procedure: A Retrospective Study in Chinahttps://artdesignp.com/journal/JCNR/7/4/10.26689/jcnr.v7i4.5053JinPing,YinBao-Min

2023

2023-07-27

Background: The study aimed to assess the efficacy and safety of dinoprostone vaginal insert in labor induction following optimization of standard operating procedure (SOP) and to discover independent predictors of vaginal delivery. Methods: This study comprised 551 pregnant women who required cervical ripening with dinoprostone before induction of labor. Using univariate and multivariate analyses, independent predictors of vaginal delivery were identified. Results: 443 of the 551 women (80.4%) gave birth vaginally. Vaginal delivery was predicted by maternal age (24–30 vs. < 24, P < 0.001; 30–35 vs. < 24, P = 0.03), gestational age (P = 0.005), birth weight (P < 0.001), parity (P = 0.001), pre-pregnancy BMI (P < 0.001), premature rupture of membranes (P = 0.001), meconium-stained amniotic fluid (P < 0.001), fundal height (P < 0.001) and the Bishop score (P < 0.001). None of the women exhibited severe postpartum hemorrhage. Conclusions: The maternal age, gestational age, birth weight, parity, body mass index, premature membrane rupture, amniotic fluid contamination, fundal height, and the Bishop score were independent predictors of vaginal delivery. These may guide the clinical use of dinoprostone for induction of labor.

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