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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">JCNR</journal-id><journal-title-group><journal-title>Journal of Clinical and Nursing Research</journal-title></journal-title-group><issn>2208-3685</issn><eissn>2208-3693</eissn><publisher><publisher-name>Bio-Byword Scientific Publishing Pty. Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26689/jcnr.v7i4.5123</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>The Effect of the Early Application of Tirofiban on Acute Ischemic Stroke (AIS) after Intravenous Thrombolysis with Urokinase</title><url>https://artdesignp.com/journal/JCNR/7/4/10.26689/jcnr.v7i4.5123</url><author>LiMingfen</author><pub-date pub-type="publication-year"><year>2023</year></pub-date><volume>7</volume><issue>4</issue><history><date date-type="pub"><published-time>2023-07-31</published-time></date></history><abstract>Objective: Discussion and analysis of the effect of the early application of Tirofiban on acute ischemic stroke (AIS) after intravenous thrombolysis with urokinase. Method: The subjects of this study are 40 patients with AIS admitted at the Yibin Fourth People’s Hospital, of which were computer-randomized into a control group (20 cases, with regular urokinase intravenous thrombolysis therapy) and a research group (20 cases, combined with early Tirofiban treatment) from January 2018 to December 2022. The intervention outcomes between these two groups were compared and analyzed. Result: The blood platelet-related parameters before treatment had no statistical difference between the two groups (P &amp;gt; 0.05), but the research group was higher than that of the control group after treatment (P &amp;lt; 0.05). The Barthel index before treatment in both groups had no statistical difference (P &amp;gt; 0.05), but the research group was higher than that of the control group after treatment (P &amp;lt; 0.05). Conclusion: Early Tirofiban treatment for patients with AIS after intravenous thrombolysis with urokinase could effectively regulate the blood platelet-related parameters, hence improving treatment benefits and living capacity for patients, with definite clinical benefits.</abstract><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>Lv Y, Liu Y, Li H, et al, 2023, Research on Efficacy of Tirofiban Combined with Alteplase Intravenous Thrombolysis in the Treatment of Mild to Moderate Acute Ischemic Stroke and TOAST Subtypes. Journal of Practical Cardio-Cerebro-Pulmonary Vascular Disease, 31(1): 112–118.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B2" content-type="article"><label>2</label><element-citation publication-type="journal"><p>Shi H, Hou M, Sun B, et al, 2021, Application and Research Progress of Tirofiban in the Treatment of Acute Ischemic Stroke. 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