JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v8i10.5724ArticleA Review on Emerging Contaminants: Effects on Human Health and Cancer Riskshttps://artdesignp.com/journal/JCNR/8/10/10.26689/jcnr.v8i10.5724KhaliqHamza,ShahzadFaiza,UllahAsad,AbidMuhammad Aziz,GulHafsa20248102024-10-24Emerging contaminants are growing health concerns that pose potential threats to the environment and human health globally. They originate from multiple sources, including rapid industrial processes, agriculture, households, and wastewater treatment plants. Despite efforts to reduce the levels of such pollutants, these harmful elements remain a serious problem for public health and the overall quality of life. Exposure to emerging contaminants can lead to various health problems, including cardiovascular diseases, brain and developmental disorders, and cancer. These contaminants can harm aquatic life, disrupt ecosystems, and contaminate drinking water sources. Cancer, a complex heterogeneous disease, can be triggered by multiple causes, including genetic and environmental factors. The rapid increase in emerging contaminants has contributed significantly to the development and proliferation of cancer. This review highlights the dangerous effects of exposure to these contaminants and explores future directions in research. Additionally, it summarizes the emerging roles of inorganic contaminants, such as engineered nanoparticles, and biological contaminants, including pathogenic bacteria, antibiotic-resistant bacteria and resistance genes, viruses, protein contaminants, microplastics, and nanoplastics, in cancer progression and treatment.

Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, et al., 2021, Oral Potentially Malignant Disorders: A Consensus Report from An International Seminar on Nomenclature and Classification, Convened by the WHO Collaborating Centre for Oral Cancer. Oral Dis, 27(8): 1862–1880. https://doi.org/10.1111/odi.13704

Aryal N, Wood J, Rijal I, et al., 2020, Fate of Environmental Pollutants: A Review. Water Environ Res, 92(10): 1587–1594. https://doi.org/10.1002/wer.1404

Kowalczyk M, Piwowarski JP, Wardaszka A, et al., 2023, Application of In Vitro Models for Studying the Mechanisms Underlying the Obesogenic Action of Endocrine-Disrupting Chemicals (EDCs) as Food Contaminants-A Review. Int J Mol Sci, 24(2): 1083. https://doi.org/10.3390/ijms24021083

Ors Kumoglu G, Sendemir A, Tanyolac MB, et al., 2022, Epigenetic Mechanisms in Cancer. Longhua Chin Med, 5: 4. https://doi.org/10.21037/lcm-21-59

Boffetta P, 2004, Epidemiology of Environmental and Occupational Cancer. Oncogene, 23(38): 6392–6403. https://doi.org/10.1038/sj.onc.1207715

Iwasaki M, Itoh H, Sawada N, et al., 2023, Exposure to Environmental Chemicals and Cancer Risk: Epidemiological Evidence from Japanese Studies. Genes Environ, 45(1): 10. https://doi.org/10.1186/s41021-023-00268-3

Malik MA, Nadeem MS, 2023, Chapter 6 – Molecular Mechanism of Action of Estrogens, Progestins, and Androgens, in Kazmi I, Karmakar S, Shaharyar MA, et al., (eds.), How Synthetic Drugs Work: Insights into Molecular Pharmacology of Classic and New Pharmaceuticals. Academic Press, Cambridge (MA), 123–159. https://doi.org/10.1016/B978-0-323-99855-0.00006-3

Du Plessis M, Fourie C, Stone W, et al., 2023, The Impact of Endocrine Disrupting Compounds and Carcinogens in Wastewater: Implications for Breast Cancer. Biochimie, 209: 103–115. https://doi.org/10.1016/j.biochi.2023.02.006

Badawi K, El Sharazly BM, Negm O, et al., 2024, Is Cadmium Genotoxicity Due to the Induction of Redox Stress and Inflammation? A Systematic Review. Antioxidants, 13(8): 932. https://doi.org/10.3390/antiox13080932

Vaibhavi I, Varsha D, Rashmi U, 2023, Genotoxic, Carcinogenic and Reproductive Studies on Aniline: A Mini Review. International Journal of Scientific Research in Biological Sciences, 10(4): 42–47.

Wei Y, He H, Han T, et al., 2023, Environmental Explanation of Prostate Cancer Progression Based on the Comprehensive Analysis of Perfluorinated Compounds. Ecotoxicology and Environmental Safety, 253: 115267. https://doi.org/10.1016/j.ecoenv.2023.115267

Li Y, Wang X, Zhu Q, et al., 2023, Organophosphate Flame Retardants in Pregnant Women: Sources, Occurrence, and Potential Risks to Pregnancy Outcomes. Environmental Science & Technology, 57(18): 7109–7128. https://doi.org/10.1021/acs.est.2c06503

Shen C, Zhang K, Shi J, et al., 2024, Association Between Brominated Flame Retardants and Risk of Endocrine-Related Cancer: A Systematic Review and Meta-Analysis. Toxicology Letters, 394: 11–22. https://doi.org/10.1016/j.toxlet.2024.02.002

Shetty SS, Deepthi D, Harshitha S, et al., 2023, Environmental Pollutants and Their Effects on Human Health. Heliyon, 9(9): e19496. https://doi.org/10.1016/j.heliyon.2023.e19496

Donley N, Cox C, Bennett K, et al., 2024, Forever Pesticides: A Growing Source of PFAS Contamination in the Environment. Environmental Health Perspectives, 132(7): 075003. https://doi.org/10.1289/EHP13954

Munzel T, Hahad O, Daiber A, et al., 2023, Soil and Water Pollution and Human Health: What Should Cardiologists Worry About? Cardiovascular Research, 119(2): 440–449. https://doi.org/10.1093/cvr/cvac082

Habib Z, Song M, Ikram S, et al., 2024, Overview of Per- and Polyfluoroalkyl Substances (PFAS), Their Applications, Sources, and Potential Impacts on Human Health. Pollutants, 4(1): 136–152. https://doi.org/10.3390/pollutants4010009

Hamid N, Hunaid M, Manzoor R, et al., 2023, An Integrated Assessment of Ecological and Human Health Risks of Per- and Polyfluoroalkyl Substances Through Toxicity Prediction Approaches. Science of the Total Environment, 905: 167213. https://doi.org/10.1016/j.scitotenv.2023.167213

Ali Hussein M, Kamalakkannan A, Valinezhad K, et al., 2024, The Dynamic Face of Cadmium-Induced Carcinogenesis: Mechanisms, Emerging Trends, and Future Directions. Curr Res Toxicol, 6: 100166. https://doi.org/10.1016/j.crtox.2024.100166

Cirovic A, Satarug S, 2024, Toxicity Tolerance in the Carcinogenesis of Environmental Cadmium. Int J Mol Sci, 25(3): 1851. https://doi.org/10.3390/ijms25031851

Liu S, Cao Y, Zhang Y, 2024, Regulatory Roles of RNA Methylation in Vascular Lesions in Ocular and Cardiopulmonary Diseases. Critical Reviews in Clinical Laboratory Sciences, 2024: 1–15.

Barouki R, Samson M, Blanc EB, et al., 2023, The Exposome and Liver Disease – How Environmental Factors Affect Liver Health. Journal of Hepatology, 79(2): 492–505. https://doi.org/10.1016/j.jhep.2023.02.034

Cousin N, 2023, Immune-Regulatory and Anti-Inflammatory Functions of Lymphatic Endothelial Cells. ETH Zurich.

Chen J, Cong X, 2023, Surface-Engineered Nanoparticles in Cancer Immune Response and Immunotherapy: Current Status and Future Prospects. Biomedicine & Pharmacotherapy, 157: 113998. https://doi.org/10.1016/j.biopha.2022.113998

Estepa-Fernandez A, Garcia-Fernandez A, Lerida-Viso A, et al., 2023, Engineering Nanoparticle Communication in Living Systems by Stigmergy: An Application to Enhance Antitumor Therapy in Triple-Negative Breast Cancer. Nanotoday, 48: 101692. https://doi.org/10.1016/j.nantod.2022.101692

Sun B, Wu W, Narasipura EA, et al., 2023, Engineering Nanoparticle Toolkits for mRNA Delivery. Advanced Drug Delivery Reviews, 200: 115042. https://doi.org/10.1016/j.addr.2023.115042

Zhao M, Li J, Chen F, et al., 2023, Engineering Nanoparticles Boost TNBC Therapy by CD24 Blockade and Mitochondrial Dynamics Regulation. J Control Release, 355: 211–227. https://doi.org/10.1016/j.jconrel.2023.01.075

Liu D, Shi Q, Liu C, et al., 2023, Effects of Endocrine-Disrupting Heavy Metals on Human Health. Toxics, 11(4): 322. https://doi.org/10.3390/toxics11040322

Singh P, Pandit S, Sinha M, et al., 2023, Computational Risk Assessment of Persistence, Bioaccumulation, and Toxicity of Novel Flame-Retardant Chemicals. Journal of Physical Chemistry A, 127(51); 10747–10757. Https://doi.org/10.1021/acs.jpca.3c04160

Zhao D, Wang P, Zhao FJ, 2022, Dietary Cadmium Exposure, Risks to Human Health and Mitigation Strategies. Critical Reviews in Environmental Science and Technology, 53(8): 939–963. https://doi.org/10.1080/10643389.2022.2099192

Abbasi R, Shineh G, Mobaraki M, et al., 2023, Structural Parameters of Nanoparticles Affecting Their Toxicity for Biomedical Applications: A Review. J Nanopart Res, 25: 43. https://doi.org/10.1007/s11051-023-05690-w

Reyes VE, 2023, Helicobacter pylori and Its Role in Gastric Cancer. Microorganisms, 11(5): 1312. https://doi.org/10.3390/microorganisms11051312

Contreras A, Sanchez SA, Rodriguez-Medina C, et al., 2000, The Role and Impact of Viruses on Cancer Development. Periodontol, 2000. Epub ahead of print. https://doi.org/10.1111/prd.12566

Liu Y, Lu L, Yang H, et al., 2023, Dysregulation of Immunity by Cigarette Smoking Promotes Inflammation and Cancer: A Review. Environmental Pollution, 339: 122730. https://doi.org/10.1016/j.envpol.2023.122730

Pezone A, Olivieri F, Napoli MV, et al., 2023, Inflammation and DNA Damage: Cause, Effect or Both. Nat Rev Rheumatol, 19(4): 200–211. https://doi.org/10.1038/s41584-022-00905-1

Shah A, Arjunan A, Baroutaji A, et al., 2023, A Review of Physicochemical and Biological Contaminants in Drinking Water and Their Impacts on Human Health. Water Science and Engineering, 16(4): 333–344. https://doi.org/10.1016/j.wse.2023.04.003

Parsa SM, Norozpour F, Momeni S, et al., 2023, Advanced Nanostructured Materials in Solar Interfacial Steam Generation and Desalination against Pathogens: Combatting Microbial-Contaminants in Water—A Critical Review. J Mater Chem A, 11: 18046–18080. https://doi.org/10.1039/D3TA03343K.

Li S, Wang S, Wong MH, et al., 2023, Changes in the Composition of Bacterial Communities and Pathogen Levels During Wastewater Treatment. Environ Sci Pollut Res Int, 30(1): 1232–1243. https://doi.org/10.1007/s11356-022-21947-8

Marques MVA, Lopes BC, Silverio THR, et al., 2023, Persistence of Pathogens and Bacterial Community Dynamics in Tropical Soil After Application of Raw Sewage. Sci Rep, 13: 13435. https://doi.org/10.1038/s41598-023-40718-0

Sah DK, Arjunan A, Lee B, et al., 2023, Reactive Oxygen Species and H. pylori Infection: A Comprehensive Review of Their Roles in Gastric Cancer Development. Antioxidants, 12(9): 1712. https://doi.org/10.3390/antiox12091712

Ahmad N, Joji RM, Shahid M, 2023, Evolution and Implementation of One Health to Control the Dissemination of Antibiotic-Resistant Bacteria and Resistance Genes: A Review. Front Cell Infect Microbiol, 12: 1065796. https://doi.org/10.3389/fcimb.2022.1065796

Bonetta S, Di Cesare A, Pignata C, et al., 2023, Occurrence of Antibiotic-Resistant Bacteria and Resistance Genes in the Urban Water Cycle. Environ Sci Pollut Res, 30: 35294–35306. https://doi.org/10.1007/s11356-022-24650-w

Tang M, Wu Z, Li W, et al., 2023, Effects of Different Composting Methods on Antibiotic-Resistant Bacteria, Antibiotic Resistance Genes, and Microbial Diversity in Dairy Cattle Manures. J Dairy Sci, 106(1): 257–273. https://doi.org/10.3168/jds.2022-22193

Yuan X, Lv Z, Zhang Z, et al., 2023, A Review of Antibiotics, Antibiotic Resistant Bacteria, and Resistance Genes in Aquaculture: Occurrence, Contamination, and Transmission. Toxics, 11(5): 420. https://doi.org/10.3390/toxics11050420

Lu Z, Liu G, Xie H, et al., 2024, Advances and Solutions in Biological Treatment for Antibiotic Wastewater with Resistance Genes: A Review. J Environ Manage, 368: 122115. https://doi.org/10.1016/j.jenvman.2024.122115

Pham MN, Nishimura F, Lan JCW, et al., 2024, Recent Advancement of Eliminating Antibiotic Resistance Bacteria and Antibiotic Resistance Genes in Livestock Waste: A Review. Environmental Technology & Innovation, 36: 103751. https://doi.org/10.1016/j.eti.2024.103751

Michaelis C, Grohmann E, 2023, Horizontal Gene Transfer of Antibiotic Resistance Genes in Biofilms. Antibiotics (Basel), 12(2): 328. https://doi.org/10.3390/antibiotics12020328

Chi W, Zou Y, Qiu T, et al., 2024, Horizontal Gene Transfer Plays a Crucial Role in the Development of Antibiotic Resistance in an Antibiotic-Free Shrimp Farming System. J Hazard Mater, 476: 135150. https://doi.org/10.1016/j.jhazmat.2024.135150

Wang Q, Wei S, Silva AF, et al., 2023, Cooperative Antibiotic Resistance Facilitates Horizontal Gene Transfer. ISME J, 17(6): 846–854. https://doi.org/10.1038/s41396-023-01393-1

Sarangi R, Bahinipati J, Mahapatra S, et al., 2023, Horizontal Gene Transfer: Implications in Human Health and Diseases. Journal of Integrative Medicine and Research, 1(1): 13–18. HTTPS://DOI.ORG/10.4103/jimr.jimr_3_22

Moyano P, Sola E, Naval MV, et al., 2023, Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools. Pharmaceutics, 15(8): 2048. https://doi.org/10.3390/pharmaceutics15082048

Zhao W, Poncet-Legrand C, Staunton S, et al., 2023, pH-Dependent Changes in Structural Stabilities of Bt Cry1Ac Toxin and Contrasting Model Proteins following Adsorption on Montmorillonite. Environ Sci Technol, 57(14): 5693–5702. https://doi.org/10.1021/acs.est.2c09310

Huang M, Bargues-Carot A, Riaz Z, et al., 2022, Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson’s Disease. Int J Mol Sci, 23(18): 10808. https://doi.org/10.3390/ijms231810808

Rodrigues ACB, de Jesus GP, Waked D, et al., 2022, Scientific Evidence about the Risks of Micro and Nanoplastics (MNPLs) to Human Health and Their Exposure Routes through the Environment. Toxics, 10(6): 308. https://doi.org/10.3390/toxics10060308

Cheng Y, Yang S, Yin L, et al., 2022, Recent Consequences of Micro-Nanaoplastics (MNPLs) in Subcellular/Molecular Environmental Pollution Toxicity on Human and Animals. Ecotoxicol Environ Saf, 249: 114385. https://doi.org/10.1016/j.ecoenv.2022.114385

Llorca M, Farre M, 2021, Current Insights into Potential Effects of Micro-Nanoplastics on Human Health by in-vitro Tests. Front Toxicol, 3: 752140. https://doi.org/10.3389/ftox.2021.752140

Barguilla I, Domenech J, Ballesteros S, et al., 2022, Long-Term Exposure to Nanoplastics Alters Molecular and Functional Traits Related to the Carcinogenic Process. J Hazard Mater, 438: 129470. https://doi.org/10.1016/j.jhazmat.2022.129470

Rashed AH, Yesilay G, Hazeem L, et al., 2023, Micro- and Nano-Plastics Contaminants in the Environment: Sources, Fate, Toxicity, Detection, Remediation, and Sustainable Perspectives. Water, 15(20): 3535. https://doi.org/10.3390/w15203535

Janney A, Powrie F, Mann EH, 2020, Host-Microbiota Maladaptation in Colorectal Cancer. Nature, 585(7826): 509–517. https://doi.org/10.1038/s41586-020-2729-3

Pleguezuelos-Manzano C, Puschhof J, Clevers H, 2022, Gut Microbiota in Colorectal Cancer: Associations, Mechanisms, and Clinical Approaches. Annual Review of Cancer Biology, 6: 65–84. https://doi.org/10.1146/annurev-cancerbio-070120-095211

Loke YL, Chew MT, Ngeow YF, et al., 2020, Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota. Front Cell Infect Microbiol, 10: 603086. https://doi.org/10.3389/fcimb.2020.603086

Groux-Degroote S, Cavdarli S, Uchimura K, et al., 2019, Glycosylation Changes in Inflammatory Diseases. Adv Protein Chem Struct Biol, 119: 111–156. https://doi.org/10.1016/bs.apcsb.2019.08.008