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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">JCNR</journal-id><journal-title-group><journal-title>Journal of Clinical and Nursing Research</journal-title></journal-title-group><issn>2208-3685</issn><eissn>2208-3693</eissn><publisher><publisher-name>Bio-Byword Scientific Publishing Pty. Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26689/jcnr.v8i12.9303</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>Advancements in Chitosan and Its Derivatives for Enhanced Wound Healing</title><url>https://artdesignp.com/journal/JCNR/8/12/10.26689/jcnr.v8i12.9303</url><author>LiuXinhong</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>8</volume><issue>12</issue><history><date date-type="pub"><published-time>2025-01-07</published-time></date></history><abstract>In recent years, the academic community has continued to explore effective methods to promote wound healing and prevent scar hyperplasia. This research area is both challenging and has attracted significant attention. Wound healing is a complex and orderly process involving the precise coordination of various growth factors, inflammatory cells, and repair cells. To optimize this intricate process, researchers have developed a series of innovative synthetic dressings designed to improve the wound healing environment. Among these dressings, the natural polymer chitosan has emerged as a preferred material due to its cost-effectiveness, renewable nature, and exceptional biocompatibility and biodegradability, as demonstrated in the biomedical field, particularly in the area of wound dressings.</abstract><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>Luo X, Huang S, Zheng C, et al., 2019, Design and Synthesis of Chitosan Based Hydrogel with Imide Bond. Guangdong Chemical Industry, 51(21): 47–49 + 101.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B2" content-type="article"><label>2</label><element-citation publication-type="journal"><p>Chen M, Wang Q, Zhu C, et al., 2019, Research Progress of Functional Hydrogels in Wound Healing. Chinese Journal of Pharmacy, 59(21): 1987–1996.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B3" content-type="article"><label>3</label><element-citation publication-type="journal"><p>Xu J, Sun C, Zhang X, et al., 2024, Chitosan Complex Adipose Mesenchymal Stem Cell Exosomes Promote Wound Healing in Diabetic Foot Ulcer Rats. Advances in Anatomical Sciences, Online ahead of print.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B4" content-type="article"><label>4</label><element-citation publication-type="journal"><p>Zu Y, Jia Q, Yang Y, et al., 2024, Preparation and Research Progress of Antibacterial and Healing Wound Dressings. Liaoning Silk, 2024(4): 94–95.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B5" content-type="article"><label>5</label><element-citation publication-type="journal"><p>Jiang A, Zhou C, Li C, et al., 2019, Preparation and Properties of Self-Healing Chitosan Antibacterial Hydrogels. Journal of Hubei University (Natural Science Edition), 46(5): 730–738.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B6" content-type="article"><label>6</label><element-citation publication-type="journal"><p>Liu K, Tang D, Fu L, et al., 2019, Radiation Preparation and Research Progress of Functional Hydrogel Wound Dressings. Journal of Radiation Research and Technology, 42(5): 3–14.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B7" content-type="article"><label>7</label><element-citation publication-type="journal"><p>Zhang G, Wang B, Cheng P, et al., 2024, Research Progress of Natural Polymer Antibacterial Hydrogel Wound Dressing. Polymer Bulletin, 37(10): 1337–1353.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B8" content-type="article"><label>8</label><element-citation publication-type="journal"><p>Liu F, 2024, Preparation of Composite Hydrogels from Chitosan/Metal-Organic Frame Materials for Wound Healing, dissertation, Qingdao University of Science and Technology.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B9" content-type="article"><label>9</label><element-citation publication-type="journal"><p>Yang Y, 2024, Preparation and Properties of Multifunctional Polymer Hydrogel Wound Dressing, dissertation, Jilin University.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B10" content-type="article"><label>10</label><element-citation publication-type="journal"><p>Li D, 2024, Preparation and Antibacterial Properties of a Novel Polydopamine-Mediated Heparin/Chitosan Active Carbon Fiber Dressing, dissertation, Changchun University of Technology.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B11" content-type="article"><label>11</label><element-citation publication-type="journal"><p>Zhang K, 2024, Preparation and Properties of Multifunctional Hydrogel Wound Dressing, dissertation, Hebei University.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B12" content-type="article"><label>12</label><element-citation publication-type="journal"><p>Xing X, 2024, Preparation of Functionalized Chitosan-Based Hydrogel Dressing and Its Application in the Repair of Infected Burns and Scalds, dissertation, Southern Medical University.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B13" content-type="article"><label>13</label><element-citation publication-type="journal"><p>Chen C, Li K, Su X, et al., 2024, Construction and Application of Controlled Release System for Chitosan-Based Aerogel. Shanghai Textile Science and Technology, 52(5): 21–27.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B14" content-type="article"><label>14</label><element-citation publication-type="journal"><p>Klimu T, Li X, Tian P, et al., 2019, Preparation and Blood Coagulability of Polycaprolactone/Chitosan Loaded Dressing. Shanghai Textile Science and Technology, 52(5): 28–33.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B15" content-type="article"><label>15</label><element-citation publication-type="journal"><p>Qi Y, 2024, Preparation of Curcumin-Chitosan Nanoparticles and Their Effect on Oral Soft Tissue Repair, dissertation, Jilin University.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
