JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v8i12.9304ArticleEvaluation Study on the Effect of Leuprolide Acetate Extended-Release Microspheres for Injection in Pediatric Precocious Pubertyhttps://artdesignp.com/journal/JCNR/8/12/10.26689/jcnr.v8i12.9304RenHuihui,SongXiaolong20258122025-01-07Objective: This study aimed to evaluate the therapeutic effects of leuprolide acetate extended-release microspheres for injection in children with pediatric precocious puberty. Methods: A total of 110 cases of pediatric precocious puberty admitted between January 2019 and December 2021 were selected and randomized into two groups using a random number table, with 55 cases in the control group and 55 cases in the experimental group. The control group received conventional treatment, while the experimental group was treated with leuprolide acetate extended-release microspheres for injection. The therapeutic effects were observed, and changes in sex hormone levels, ovarian volume, growth indices, and the incidence of adverse reactions were statistically compared between the groups. Results: The experimental group demonstrated superior outcomes in terms of sex hormone levels, ovarian volume, and growth indices compared to the control group. Additionally, the incidence of adverse reactions in the experimental group was significantly lower (P < 0.05). Conclusion: The application of leuprolide acetate extended-release microspheres for the treatment of pediatric precocious puberty is associated with improved therapeutic effects and higher safety.

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