JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v8i3.6308ArticleAnalgesic Effect of Combined Spinal-Epidural Anesthesia and its Effect on TNF-α and CRP Levels in Elderly Patients with Hip Fracture During Surgical Treatmenthttps://artdesignp.com/journal/JCNR/8/3/10.26689/jcnr.v8i3.6308XuJie,LiLinyan,WangNing2024832024-03-24Objective: To observe the analgesic effect of combined spinal and epidural anesthesia on older patients undergoing hip fracture surgery. Method: One hundred and twenty elderly hip fracture surgery patients treated in our hospital from January 2021 to December 2022 were selected and randomly divided into two groups, with 60 cases in the experimental group and 60 in the control group. The experimental group was given combined spinal-epidural anesthesia intervention measures, while the control group was given epidural anesthesia intervention measures. The analgesic effect, tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP) levels, and other observation indicators were analyzed after anesthesia intervention. Result: After the intervention, the analgesic effect and the evaluation results of the subjects in the experimental group were better than those in the control group (P < 0.05); the obtained values of TNF-α and CRP levels in the experimental group were higher than those of the control group (P < 0.05). Conclusion: The combined spinal- epidural anesthesia intervention demonstrated positive outcomes. The analgesic effect of patients during surgery and their inflammatory factor levels improved, which makes this intervention worthy of clinical application and promotion.

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