Analysis of the Antidepressant Effects and Mechanisms of Icariin II Based on The GABAergic Nervous System

JCNR

Journal of Clinical and Nursing Research

2208-36852208-3693

Bio-Byword Scientific Publishing Pty. Ltd.

10.26689/jcnr.v8i3.6317

Article

Analysis of the Antidepressant Effects and Mechanisms of Icariin II Based on The GABAergic Nervous Systemhttps://artdesignp.com/journal/JCNR/8/3/10.26689/jcnr.v8i3.6317HuangHongchen,YuQinglin,ZhaoTong,ZhangYijian

2024

2024-03-24

This article summarized the research progress on the antidepressant mechanism of icariin II, mainly elaborating on its mechanism from five aspects: GABAergic nervous system, inflammatory response, oxidative stress, neurotrophic factors, and neurotransmitters in the brain. Its clinical application value was further explored to provide a theoretical basis for the development and utilization of icariin II in treating depression.

Wen C, Xiao H, Tian Y, et al., 2023, Study on Improving the Cognitive Function of APP/PS1 Double Transgenic Mice by Icariin II. Journal of Changchun University of Traditional Chinese Medicine, 39(12): 1339–1345.

Liu Y, Xi O, Liu Y, 2022, Effects of Icariin II on Brain Cell Apoptosis and Autophagy in Rats with Cerebral Ischemia/ Reperfusion Injury. Journal of Hubei University of Traditional Chinese Medicine, 24(1): 53–57.

Ke C, 2019, Preliminary Study on the Protective Effect and Mechanism of Icariin II on Hypoxic Axonal Damage of Rat Cortical Neurons, dissertation, Zunyi Medical University.

Zhang L, Zhang L, Wang J, et al., 2023, Effects of Fingolimod on Behavior and Monoamine Neurotransmitters in Depressed Rats. Chinese Journal of Gerontology, 43(24): 6040–6043.

Wang Y, Song K, Song Z, et al., 2023, Effects of Mongolian medicine Qingxin Agarwood Bawei Powder on Behavior and Monoamine Neurotransmitters in Acute Depression Model Mice. Journal of Baotou Medical College, 39(11): 92–96.

Hou M, Li T, Ni J, et al., 2022, Meta-Analysis of The Effect of Acupuncture on Monoamine Neurotransmitters in Animal Models of Vascular Dementia. Global Chinese Medicine, 15(12): 2401–2407.

Ming L, 2022, Effect of Icariin on 6-OHDA-Induced Apoptosis of Dopaminergic Neurons, dissertation, Zunyi Medical University.

Wang Y, 2020, The Therapeutic Effect of Icariin on The Aggravation of Symptoms and Pathological Changes of Alzheimer’s Disease Caused by Psychological Stress, dissertation, Shandong University.

Kokkosis GA, Madeira MM, Hage Z, et al., 2023, Chronic Psychosocial Stress Triggers Microglia/Macrophage- Induced Inflammatory Responses, Leading to Neuronal Dysfunction and Depression-Related Behaviors (English). Neural Injury and Function Reconstruction, 18(12): 825.

Zheng Y, Gao J, Gong Q, 2019, Icariin II Inhibits Lipopolysaccharide-Induced Astrocyte Inflammatory Response by Regulating The IKK/I?b/NF-?b Signaling Pathway. Chinese Pharmacology and Toxicology Magazine, 33(6): 459– 460.

Zhou J, 2018, Study on Reducing Lipopolysaccharide-Induced Neuroinflammatory Response in Rats Through Icariin II Pretreatment through TLR4/Myd88/NF-?b Pathway, dissertation, Zunyi Medical College.

Zeng L, Yin C, Liu Y, et al., 2017, Icariin II Downregulates APP, A? (1–42), and RAGE Protein Levels in The Hippocampus of APP/PS1 Transgenic Mice and Inhibits Inflammatory Response [J]. Journal of Zunyi Medical College, 40(1): 22–26.

Sun J, 2023, The Protective Effect and Mechanism of Icariin II on The Bladder in a Rat Model of Radiation Cystitis, dissertation, Changchun University of Traditional Chinese Medicine.

Hu D, 2021, Icariin II Reduces Hypoxia-Induced Cardiomyocyte Damage by Regulating the Mir-7-5p/BTG2 Axis and Activating The PI3K/Akt Signaling Pathway, dissertation, Nanchang University.

Ma C, Huang F, Gong Q, et al., 2021, Effects of Icariin II on Oxidative Stress Damage in bEnd.3 Cells Induced by Hydrogen Peroxide. Traditional Chinese Medicine Pharmacology and Clinical Medicine, 37(6): 43–47.

Ma C, 2021, Study on the Protective Effect and Mechanism of Icariin II on Cerebral Ischemia-Reperfusion Injury Mice, dissertation, Zunyi Medical University.

Feng L, 2018, Study on The Damage Effect and Mechanism of PC12 Cells Induced by Icariin II Antioxidant Sugar Deprivation/Reoxygenation Complex Sugar, dissertation, Zunyi Medical College.

Gao J, Lei M, Ling H, et al., 2016, Study on the Protective Effect of Icariin II on Oxidative Damage of SH-SY5Y Cells Induced by Hydrogen Peroxide Based on ROS/GSK-3? Signaling Pathway. Pharmacology of Traditional Chinese Medicine and Clinical, 32(5): 23–27.

Liu S, 2018, ICS? Resists PC12 Cell Apoptosis Induced by Amyloid 25–35 Fragment by Activating The BDNF/Trkb Signaling Pathway, dissertation, Zunyi Medical College.

Chen Y, Ju X, Cao F, et al., 2023, Research on the Pathological Mechanism of Hippocampal MiR-98-5p Involved in Depression by Regulating Brain-Derived Neurotrophic Factor. Journal of Xuzhou Medical University, 43(12): 874– 881.

Xin Y, A Yisi, Wei H, et al., 2023, Correlation Between Serum 5-HT, Obestatin, APRIL and Neurological Function in Elderly Stroke Patients and Their Predictive Value for Post-Stroke Depression. Progress in Modern Biomedicine, 23(22): 4309–4314.

Gao C, Zhi Y, 2020, Study on the Improving Effect of Icariin II on Regulating the MiR-141-3p/Notch/Nrf2 Axis on Neurological Function in Rats with Focal Cerebral Ischemia Model. Chinese Pharmacy, 31(19): 2386–2391.

Su Z, Li C, Cao J, et al., 2023, Feasibility Experimental Study on the Use of Serum, Plasma and Platelet 5-HT as a Molecular Marker for the Diagnosis and Efficacy Evaluation of Depression. Chinese Journal of Pharmacology and Toxicology, 37(1): 24.