JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v8i6.7293ArticleStudy on The Current Status and Progress of Clinical Application of Ciprofolhttps://artdesignp.com/journal/JCNR/8/6/10.26689/jcnr.v8i6.7293LiuLihua,ShenXiaokun2024862024-07-23Ciprofol, as a new type of short-acting intravenous anesthetic drug, belongs to the category of gamma-aminobutyric acid (GABA) receptor agonists. Its unique chemical structure, through the introduction of the cyclopropyl group in the isopropyl side chain of propofol, constructs a new type of chiral molecule, which significantly enhances the spatial effect, and improves the affinity for GABA receptors. Its pharmacological properties are characterized by high potency, rapid onset of action, rapid recovery, low accumulation, and minimal adverse reactions. Therefore, it has a wide range of applications in various endoscopic diagnostic and therapeutic operations, ICU sedation, and general anesthesia. In this paper, the related knowledge of ciprofol and the development of clinical application research are comprehensively sorted out and synthesized, to provide a solid theoretical basis for the rational application of ciprofol in clinical practice. At the same time, the future research direction of ciprofol will also be prospected to provide valuable references for research in related fields.

Li L, Li J, Li Z, et al., 2023, Current Status and Research Progress of Clinical Application of Ciprofol. Journal of Cardiopulmonary Vascular Disease, 42(1): 97–99.

Lu Z, 2020, Progress of sedation in pediatric MRI examinations, thesis, Chongqing Medical University.

Hu C, Ou X, Teng Y, et al., 2021, Sedation Effects Produced by a Ciprofol Initial Infusion or Bolus Dose Followed by Continuous Maintenance Infusion in Healthy Subjects: A Phase I Trial. Advances in Therapy, 38(11): 5484–5500. https://doi.org/10.1007/s12325-021-01914-4

Tang E, Xu H, Cai M, et al., 2024, Comparison of Anesthesia Effects Between Ciprofol and Propofol Combined with Sufentanil in Painless Colonoscopy. Laboratory Medicine and Clinics, 21(3): 393–397 + 401.

Wang R, Lin Y, Wang Y, et al., 2023, Comparison of Anesthesia Effects Between Ciprofol and Propofol for Daytime Hysteroscopic Surgery. Guangdong Medicine, 44(2): 188–193.

Hu Z, Yue D, Hu Z, et al., 2023, Application of Ciprofol Combined with Nalbuphine in Outpatient Painless Abortion. Journal of Clinical Anesthesiology, 39(12): 1328–1331.

Li J, Wang X, Liu J, et al., 2022, Comparison of Ciprofol (HSK3486) Versus Propofol for The Induction of Deep Sedation During Gastroscopy and Colonoscopy Procedures: A Multi-Center, Non-Inferiority, Randomized, Controlled Phase 3 Clinical Trial. Basic and Clinical Pharmacology and Toxicology, 131(2): 138–148. https://doi.org/10.1111/bcpt.13761

Yang D, Zhang W, Ruan Z, et al., 2023, Drug-drug Interaction Study of Ciprofol and Sodium Divalproex. Pharmacokinetics, Pharmacodynamics, and Safety in Healthy Chinese Subjects. Clinical and Translational Science, 16(10): 1972–1981. https://doi.org/10.1111/cts.13605

Desousa KA, 2016, Pain on Propofol Injection: Causes and Remedies. Indian Journal of Pharmacology, 48(6): 617–623. https://doi.org/10.4103/0253-7613.194845