JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v8i6.7605ArticleAdvances in Pharmacological Effects of Steviosidehttps://artdesignp.com/journal/JCNR/8/6/10.26689/jcnr.v8i6.7605FuShiqin,HuangYanling,XieYiting,ZhangJing2024862024-07-17Stevioside is a low-calorie high-power sweetener with a variety of positive pharmacological effects. With the growing attention to health, stevia leaf has garnered widespread interest at home and abroad. This article reviews the main pharmacological effects of stevioside and their mechanisms, in order to provide references for the research on the edible and medicinal value of stevioside.

Li Y, Li Y, 1983, Extraction of Stevioside from Stevia. Yunnan Chemical Technology, (04): 75–77.

Ding N, Hao Z, Chen X, et al., 2005, Research and Development of Stevia and Its Glycosides. Shanghai Agricultural Science and Technology, (04): 8–10.

Wang L, Jia J, 2023, Application and Development Trend Analysis of Stevioside in Food. Modern Food, 29(14): 38–42.

Gregersen S, Jeppesen PB, Holst JJ, et al., 2004, Antihyperglycemic Effects of Stevioside in Type 2 Diabetic Subjects. Metabolism, 53(1): 73–76.

Li Z, 2020, Therapeutic Effects of Stevioside Root Polysaccharide on Nonalcoholic Fatty Liver in Rats, dissertation, Wannan Medical College.

Stamataki NS, Crooks B, Ahmed A, et al., 2020, Effects of the Daily Consumption of Stevia on Glucose Homeostasis, Body Weight, and Energy Intake: A Randomised Open-Label 12-Week Trial in Healthy Adults. Nutrients, (12): 3049.

Wong KL, Yang HY, Chan P, et al., 2004, Isosteviol as a Potassium Channel Opener to Lower Intracellular Calcium Concentrations in Cultured Aortic Smooth Muscle Cells. Planta Medica, 70(02): 108–112.

Chan P, Tomlinson B, Chen YJ, et al., 2000, A Double-Blind Placebo-Controlled Study of the Effectiveness and Tolerability of Oral Stevioside in Human Hypertension. Br J Clin Pharmacol, 50(3): 215–220.

Chan P, Xu DY, Liu JC, et al., 1998, The Effect of Stevioside on Blood Pressure and Plasma Catecholamines in Spontaneously Hypertensive Rats. Life Sciences, 63(19): 1679–1684.

Paul S, Sengupta S, Bandyopadhyay TK, et al., 2012, Stevioside Induced ROS-Mediated Apoptosis Through Mitochondrial Pathway in human breast cancer cell Line MCF-7. Nutr Cancer, 64(7): 1087–1094.

Yu S, Zhang D, 2014, Research Progress on Biological Activities of Stevioside and Its Derivatives. Progress in Pharmacy, 38(08): 577–584.

Wang W, Liu D, 1989, Application of Stevia in the Prevention of Dental Caries: Animal and In Vitro Experimental Study. J Practical Stomatology, (01): 19–22.

Rezaei-Soufi L, Raedi S, Alikhani MY, et al., 2016, Comparison of the Effect of Stevia Extract with Glucose and Fructose on Dental Enamel Caries Formation. J Chem Pharmac Sci, (9): 685–689.

Shiozaki K, Fujii A, Nakano T, et al., 2006, Inhibitory Effects of Hot Water Extract of the Stevia Stem on the Contractile Response of the Smooth Muscle of the Guinea Pig Ileum. Biosci Biotechnol Biochem, 70(2): 489–494.

Sehar I, Kaul A, Bani S, et al., 2008, Immune Up-Regulatory Response of a Non-Caloric Natural Sweetener, Stevioside. Chem Biol Interact, 173(2): 115–121.

Wang T, Guo M, Song X, et al., 2014, Stevioside Plays an Anti-Inflammatory Role by Regulating the NF-KappaB and MAPK Pathways in S. aureus-Infected Mouse Mammary Glands. Inflammation, (37): 1837–1846.

Yang Y, Li F, Ju Z, et al. 2011, Application Status and Development Prospect of Stevia. Fermentation Technology Communication, 40(01): 40–44.

Chen J, 2019, In Vitro Metabolism and Biological Activity of Stevioside, dissertation, Jiangnan University.

Yasukawa K, Kitanaka S, Seo S, 2002, Inhibitory Effect of Stevioside on Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate in Two-Stage Carcinogenesis in Mouse Skin. Biol Pharm Bull, 25(11): 1488–1490.