JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v8i7.7868ArticleAnalysis of the Effect of Laparoscopic Versus Open Cholecystectomy in Patients with Cholelithiasis and the Effect on CRP and IL-1β Levelshttps://artdesignp.com/journal/JCNR/8/7/10.26689/jcnr.v8i7.7868ChenHui2024872024-08-12Objective: To evaluate the therapeutic effect of laparoscopic cholecystectomy (LC) and open cholecystectomy (OC) on cholelithiasis. Methods: 92 cases of cholelithiasis patients admitted to the hospital in the past 2 years were selected and grouped by random number table; the observation group was treated with LC; the reference group was treated with OC, and the inflammatory factor and other indexes were compared. Results: The total effective rate of the observation group was higher than that of the reference group, and the perioperative indexes were better than that of the reference group (P < 0.05). Preoperatively, the C-reactive protein (CRP) and interleukin-1β (IL-1β) levels and immune function indexes of the two groups were compared, and no difference was seen (P >0.05). At 5 days postoperatively, the CRP and IL-1β levels of the observation group were lower than those of the reference group, and the immune function indicators were higher than those of the reference group (P < 0.05). The complication rate of the observation group was lower than that of the reference group (P < 0.05). Conclusion: LC can increase the effective rate of cholelithiasis patients, improve their perioperative indexes, reduce the inflammatory response, protect patients’ immune function, and ensure higher surgical safety.

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