<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">JCNR</journal-id><journal-title-group><journal-title>Journal of Clinical and Nursing Research</journal-title></journal-title-group><issn>2208-3685</issn><eissn>2208-3693</eissn><publisher><publisher-name>Bio-Byword Scientific Publishing Pty. Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26689/jcnr.v8i7.7870</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>Advances in the Pathogenesis and Pharmacologic Treatment of Diabetic Cataracts</title><url>https://artdesignp.com/journal/JCNR/8/7/10.26689/jcnr.v8i7.7870</url><author>KouXin</author><pub-date pub-type="publication-year"><year>2024</year></pub-date><volume>8</volume><issue>7</issue><history><date date-type="pub"><published-time>2024-08-12</published-time></date></history><abstract>Diabetic cataract (DC) is a common complication prior to diabetes mellitus, which is a metabolic disease with pathogenesis including abnormal metabolism of polyphenol pathway (PP) and non-enzymatic glycosylation (NEG) of proteins, etc. The therapeutic drugs are mainly aldose reductase inhibitors (ARIs) and glycosylation inhibitors. The therapeutic regimens for DC are becoming more and more diversified due to the development of biological testing and clinical research technology, thus improving its clinical efficacy. With the development of biological testing and clinical research technology, the treatment options for DC have become increasingly diversified and the treatment specificity has been improved, improving its clinical efficacy. In order to comprehensively analyze the pathogenesis and pharmacological treatment of this disease, the following review is made.</abstract><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>Gou Q, Li H, 2022, Study on Diabetes-Related Ocular Changes and Complications. Medical Information, 35(18): 153–156.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B2" content-type="article"><label>2</label><element-citation publication-type="journal"><p>Li X, Liao J, Huang K, et al., 2023, Application Value of Serum 1,5-AG in Early Diagnosis of Type 2 Diabetes Mellitus. Modern Medicine, 51(9): 1220–1226.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B3" content-type="article"><label>3</label><element-citation publication-type="journal"><p>Han Z, Li J, Xu Z, et al., 2023, Design, Synthesis and Activity Evaluation of Multifunctional Aldose Reductase Inhibitors with Novel Quinolone Structure. Chemical Research and Application, 35(3): 691–697.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B4" content-type="article"><label>4</label><element-citation publication-type="journal"><p>Ma T, 2021, Effects of Inhibitors of Glycosylation End Products on Diabetic Complications. Medical Information, 34(10): 65–67, 71.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B5" content-type="article"><label>5</label><element-citation publication-type="journal"><p>Liu Y, Du S, Shao J, et al., 2020, Expression of Receptor for Advanced Glycosylation End Products (RAGE) in the Anterior Capsule Membrane and Human Lens Epithelial Cells of Patients with Diabetic Cataract and Age-Related Cataract. New Progress in Ophthalmology, 40(11): 1015–1019.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B6" content-type="article"><label>6</label><element-citation publication-type="journal"><p>Li Q, Wang G, Chen J, et al., 2023, Effect of Hesperidin Modulation of Keap1/Nrf2/ARE Signaling Pathway on Oxidative Stress Injury in D-Galactose-Induced Cataract Rats. Hebei Medicine, 29(2): 195–200.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B7" content-type="article"><label>7</label><element-citation publication-type="journal"><p>Jiang F, Zhu J, Liu Q, et al., 2020, Effects of Aldose Reductase Inhibitors on NLRP3 Inflammasome Expression in Patients with Diabetic Peripheral Neuropathy. Hainan Medicine, 31(21): 2750–2754.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B8" content-type="article"><label>8</label><element-citation publication-type="journal"><p>Chen L, 2021, Clinical Study of Aldose Reductase Inhibitor in the Treatment of Diabetic Peripheral Neuropathy. Diabetes World, 18(3): 55.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B9" content-type="article"><label>9</label><element-citation publication-type="journal"><p>Wang J, Yuan Y, 2020, Effects of Epalrestat Combined with Taurine on Postoperative Inflammation and Oxidative Stress Factors in Diabetic Cataract Patients. Modern Medicine, 48(5): 602–607.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B10" content-type="article"><label>10</label><element-citation publication-type="journal"><p>Zheng J, Zheng Y, Chen F, 2021, Effects of Panax Ginseng Total Saponin Combined with Pimagedine Treatment on Blood CRP, TNF-Alpha, MDA and SOD Levels in Renal Function of Rats with Diabetic Nephropathy. Hebei Medicine, 27(9): 1414–1418.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B11" content-type="article"><label>11</label><element-citation publication-type="journal"><p>Han X, Yan Q, Wang X, 2020, Proteomic Analysis of Lysine Acetylation in Mouse Lens Epithelial Cells Under High Glucose Microenvironment. Journal of China Medical University, 49(8): 694–700.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B12" content-type="article"><label>12</label><element-citation publication-type="journal"><p>Wu J, Zhao S, Wu W, et al., 2018, Inhibitory Effect of Shiquan Dajian Tang on Spontaneous Tumor of Lens in SV40T Antigen Transgenic Mice and Its Molecular Mechanism. Journal of Jilin University (Medical Edition), 44(1): 5.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B13" content-type="article"><label>13</label><element-citation publication-type="journal"><p>Yin L, Yao Y, 2023, Clinical Study of Vitamin A Palmitate Ophthalmic Gel Combined with Diclofosol Sodium Eye Drops for the Treatment of Dry Eye After Cataract Ultrasonic Emulsification. Journal of Nantong University (Medical Edition), 43(2): 137–140.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B14" content-type="article"><label>14</label><element-citation publication-type="journal"><p>Liu J, Xu X, Kang W, et al., 2022, Effects of Dandelion Flavonoids on Antioxidant Enzyme Activities and Related Gene Expressions in ICR Mice. Genomics and Applied Biology, 6(1): 41.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
