JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v9i10.12554ArticleStudy on the Correlation between Irisin Expression and the Healing of Diabetic Skin Injuryhttps://artdesignp.com/journal/JCNR/9/10/10.26689/jcnr.v9i10.12554YuXuefeng,JiangXi20259102025-11-03A diabetic skin ulcer model was established by combining streptozotocin (STZ) administration with full-thickness skin defect surgery to evaluate the changes in irisin levels during the healing process. The experiment was divided into 2 groups, with 6 mice in each group: the normal control group and the diabetic skin injury group. Compared with the normal group, the model injury group showed a significant increase in blood glucose (p < 0.001), a significant decrease in healing rate (p < 0.001), and a significant decrease in irisin levels (p < 0.001) after 14 days. Irisin levels were positively correlated with blood glucose and positively correlated with wound healing rate. In conclusion, irisin may be a potential therapeutic target for the treatment of diabetic skin injury.

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