JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v9i11.11754ArticleThe Impact of Metabolic Syndrome on Coronary Artery Disease in Middle-Aged and Older Womenhttps://artdesignp.com/journal/JCNR/9/11/10.26689/jcnr.v9i11.11754HongBan20259112025-12-09Objective: This study aims to assess the influence of Metabolic Syndrome (MS) on the risk and severity of Coronary Artery Disease (CAD) in middle-aged and elderly women (40–75 years old), to inform evidence-based prevention and management strategies for this population. Methods: A retrospective study enrolled 200 middle-aged and elderly female patients (aged 40–75 years) who underwent coronary angiography (CAG) at our hospital between January 2024 and March 2025. Participants were divided into an MS group (n = 88) and a non-MS group (n = 112) based on meeting MS diagnostic criteria. General clinical data including age, body mass index [BMI], blood pressure, blood glucose, blood lipids, and more were collected for both groups. The severity of coronary artery lesions was quantified using the Gensini score. Differences in the positive rate of coronary artery lesions, the number of diseased vessel segments, and Gensini scores between the two groups were compared. Results: Patients in the MS group exhibited a significantly higher prevalence of coronary artery lesions (79.55% vs. 48.21%, p < 0.001), a greater proportion of multivessel disease (46.59% vs. 18.75%, p < 0.05), and higher Gensini scores (25.72 ± 14.28 vs. 16.35 ± 9.86, p < 0.05) compared to the non-MS group. Conclusion: Metabolic syndrome is a significant risk factor for coronary artery disease in middle-aged and elderly women, substantially increasing both the incidence and severity of coronary lesions. Clinical efforts should focus on enhancing screening and comprehensive intervention for metabolic syndrome in this population to reduce the risk of coronary heart disease.

Dai C, Deng Y, He S, et al., 2024, Predictive Value of Monocyte Count/High-Density Lipoprotein Cholesterol and Thyroid-Stimulating Hormone in Postmenopausal Women with Acute Coronary Syndrome and Their Correlation with Coronary Artery Lesions. Chinese General Practice, 27(33): 4132–4138.

Chen Y, Diao X, 2024, Factors Influencing the Number of Coronary Lesions in Patients with Atrial Fibrillation and Coronary Heart Disease. Journal of Guizhou Medical University, 49(04): 603–608.

Yin P, Fan L, Hu J, et al., 2024, Analysis of Risk Factors and Lesion Characteristics in Early-Onset Acute Coronary Syndrome Patients of Different Genders. Journal of Cardiovascular Rehabilitation Medicine, 33(02): 136–139.

Li J, Guo L, Liu L, et al., 2024, Clinical Characteristics of Single-Vessel Disease in Early-Onset Female Patients with Coronary Heart Disease. Cardiovascular Disease Prevention and Treatment Knowledge, 14(05): 3–6.

Wang R, Xu S, Wang L, et al., 2022, Prevalence of Metabolic Syndrome Among Male Alcohol Users Under Different Diagnostic Criteria. Chinese Journal of Psychiatry, 55(4): 288–294.

Zheng C, Guo J, Zhou J, et al., 2023, Correlation Between SYNTAX Score in Coronary Angiography and PLR, NLR, RDW in Postmenopausal Women with Coronary Heart Disease. Imaging Science and Photochemistry, 41(01): 84–89.

Mao P, Lu Y, 2022, Risk Factors and Coronary Artery Characteristics in Middle-Aged and Young Patients with Acute Coronary Syndrome. Journal of Cardiovascular and Cerebrovascular Diseases: Chinese and Western Medicine Integration, 20(22): 4163–4172.

Li H, 2015, Analysis of Coronary Artery Disease Severity and Risk Factors in Middle-Aged and Elderly Female Patients with Coronary Heart Disease. Medical Theory and Practice, 28(14): 1830–1831 + 1847.

He W, Zhang D, Qin S, et al., 2014, Study on Risk Factors and Coronary Artery Lesion Characteristics in Middle-Aged and Elderly Female Patients with Coronary Heart Disease. Lingnan Journal of Cardiovascular Diseases, 20(05): 575–577.

Dai T, Liang X, Qi G, 2004, Analysis of Coronary Artery Lesion Characteristics in Middle-Aged and Elderly Women with Coronary Heart Disease and Hypertension. Journal of Clinical Cardiovascular Diseases, 2004(02): 112.