<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">JCNR</journal-id><journal-title-group><journal-title>Journal of Clinical and Nursing Research</journal-title></journal-title-group><issn>2208-3685</issn><eissn>2208-3693</eissn><publisher><publisher-name>Bio-Byword Scientific Publishing Pty. Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.26689/jcnr.v9i11.13002</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>Technical Guidelines for Autologous Skin-Grafting Surgery to Prevent Stenosis Following Super Minimally Invasive Resection of Large-Area Esophageal Lesions</title><url>https://artdesignp.com/journal/JCNR/9/11/10.26689/jcnr.v9i11.13002</url><author>ChenQianqian,WangRunze,LiHuikai,LinghuEnqiang</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>9</volume><issue>11</issue><history><date date-type="pub"><published-time>2025-12-10</published-time></date></history><abstract>Autologous Skin-Grafting Surgery after Super Minimally Invasive Resection (ASGS-SMIR) is a novel endoscopic repair technique developed under the guidance of the Super Minimally Invasive Surgery (SMIS) concept. Based on previous clinical research results and combined with the ten core treatment principles of SMIS, this guideline systematically elaborates on the indications, contraindications, preoperative evaluation, surgical operation standards, postoperative management, and efficacy evaluation system of ASGS-SMIR. This surgery achieves effective repair of large-area mucosal defects and stenosis prevention in the esophagus through the technical process of “skin flap harvesting, mesh processing, sleeve suture, and stent fixation”. The purpose of this guideline is to promote the standardized and normalized application of this technique and provide guidance for clinical practice.</abstract><keywords/></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>Chen Q, Yuan Y, Linghu E, 2025, Advances in the Diagnosis and Treatment of Gastrointestinal Tumors Under the Concept of Super Minimally Invasive Surgery. J Transl Int Med, 13(3): 183–186.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B2" content-type="article"><label>2</label><element-citation publication-type="journal"><p>Linghu E, 2022, A New Stage of Surgical Treatment: Super Minimally Invasive Surgery. Chin Med J (Engl), 135(1): 1–3.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B3" content-type="article"><label>3</label><element-citation publication-type="journal"><p>Linghu E, 2016, A New Stage in the History of Surgical Development: Super Minimally Invasive Technology. Chinese Journal of Gastrointestinal Endoscopy, 33: 97–99.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B4" content-type="article"><label>4</label><element-citation publication-type="journal"><p>Chinese Society of Digestive Endoscopy, Chinese Medical Doctor Association Endoscopy Physicians Branch, Beijing Medical Association Digestive Endoscopy Branch, 2020, Expert Consensus on Endoscopic Prevention and Treatment of Benign and Malignant Esophageal Stenosis in China (2020, Beijing). Chinese Journal of Gastrointestinal Endoscopy, 7(4): 165–175.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B5" content-type="article"><label>5</label><element-citation publication-type="journal"><p>Kobayashi S, Kanai N, Ohki T, et al., 2014, Prevention of Esophageal Strictures After Endoscopic Submucosal Dissection. World J Gastroenterol, 20(41): 15098–15109.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B6" content-type="article"><label>6</label><element-citation publication-type="journal"><p>Tang J, Kong F, Li J, et al., 2021, Independent Risk Factors for Esophageal Refractory Stricture After Extensive Endoscopic Submucosal Dissection. Surg Endosc, 35(7): 3618–3627.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B7" content-type="article"><label>7</label><element-citation publication-type="journal"><p>Kanai N, Yamato M, Ohki T, et al., 2012, Fabricated Autologous Epidermal Cell Sheets for the Prevention of Esophageal Stricture After Circumferential ESD in a Porcine Model. Gastrointest Endosc, 76(4): 873–881.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B8" content-type="article"><label>8</label><element-citation publication-type="journal"><p>Sakurai T, Miyazaki S, Miyata G, et al., 2007, Autologous Buccal Keratinocyte Implantation for the Prevention of Stenosis After EMR of the Esophagus. Gastrointest Endosc, 66(1): 167–173.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B9" content-type="article"><label>9</label><element-citation publication-type="journal"><p>Yang F, Hu Y, Shi Z, et al., 2024, The Occurrence and Development Mechanisms of Esophageal Stricture: State of the Art Review. J Transl Med, 22(1): 123.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B10" content-type="article"><label>10</label><element-citation publication-type="journal"><p>Zou J, Chai N, Linghu E, et al., 2021, Autologous Skin-Grafting Surgery to Prevent Esophageal Stenosis After Complete Circular Endoscopic Submucosal Tunnel Dissection: A Case-Matched Controlled Study. Surg Endosc, 35(11): 5962–5970.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B11" content-type="article"><label>11</label><element-citation publication-type="journal"><p>Li L, Wang Z, Wang N, et al., 2023, Self-Help Inflatable Balloon Versus Autologous Skin-Grafting Surgery for Preventing Esophageal Stricture After Complete Circular Endoscopic Submucosal Dissection: A Propensity Score Matching Analysis. Surg Endosc, 37: 3710–3719.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B12" content-type="article"><label>12</label><element-citation publication-type="journal"><p>Chai N, Zou J, Linghu E, et al., 2019, Autologous Skin-Grafting Surgery to Prevent Esophageal Stenosis After Complete Circular Endoscopic Submucosal Tunnel Dissection for Superficial Esophageal Neoplasms. Am J Gastroenterol, 114: 822–825.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B13" content-type="article"><label>13</label><element-citation publication-type="journal"><p>Liu S, Chai N, Lin Y, et al., 2024, Autologous Skin-Grafting Surgery with Novel Continuous Liquid Infusion Stent for Prevention of Esophageal Stenosis After Complete Circular Endoscopic Submucosal Tunnel Dissection. Endoscopy, 56: E290–E291.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B14" content-type="article"><label>14</label><element-citation publication-type="journal"><p>Xu N, Li L, Zou J, et al., 2024, PRP Improves the Outcomes of Autologous Skin Graft Transplantation on the Esophagus by Promoting Angiogenesis and Inhibiting Fibrosis and Inflammation. J Transl Int Med, 12(4): 384–394.</p><pub-id pub-id-type="doi"/></element-citation></ref><ref id="B15" content-type="article"><label>15</label><element-citation publication-type="journal"><p>Chen Q, Linghu E, 2024, Development, Implementation Principles, and Application of Super Minimally Invasive Surgery for Digestive Endoscopy. Chinese Medical Journal, 104(35): 3279–3281.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
