JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v9i12.12817ArticleMediating Effects of Knowledge, Attitudes, and Practice of Rehabilitation on the Relationship between Fatigue and Kinesiophobia in Patients with Coronary Heart Diseasehttps://artdesignp.com/journal/JCNR/9/12/10.26689/jcnr.v9i12.12817BiLele,ChengZhuoting,ChengLi,ZhangTaotao20259122025-12-31This study aimed to investigate the mediating role of knowledge, attitude, and practice (KAP) in the relationship between fatigue and kinesiophobia in 200 coronary heart disease patients from three Chinese tertiary hospitals. Using validated scales (MFSI-SF, TSK-SV Heart, and the Rehabilitation Exercise Knowledge-Attitude-Practice Scale for Patients ), data analysis via SPSS 25.0 and AMOS 24.0 structural equation modeling identified a significant KAP-mediated pathway (total indirect effect=0.377). KAP of rehabilitation was significantly negatively correlated with fatigue (r=-0.51, p<0.01) and kinesiophobia (r=-0.60, p<0.01), whereas fatigue was significantly positively correlated with kinesiophobia (r=0.678, p<0.01). Results indicate that fatigue amplifies kinesiophobia by compromising KAP of rehabilitation.A significant mediating effect of KAP of rehabilitation on the relationship between fatigue and kinesiophobia was found. Improving patient fatigue and the knowledge, attitudes, and practices of rehabilitation can help reduce kinesiophobia.

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