JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v9i4.10413ArticleMultidimensional Roles of Pears in Pear Paste: A Systematic Analysis from Molecular Mechanisms to Clinical Translationshttps://artdesignp.com/journal/JCNR/9/4/10.26689/jcnr.v9i4.10413ChengPing,WangQingyao,QiuMingjie,LvCunfei,DaiXinyu,XuWenpin2025942025-04-29Pear paste is a traditional preparation with both medicinal and nutritional functions. The “pear”, as its core ingredient, plays a crucial role in the efficacy of the preparation. This paper, through the interdisciplinary integration of evidence from traditional Chinese medicine, food chemistry, molecular biology, and clinical medicine, constructs a complete “raw material-component transformation-biological regulation” model for the first time. It is found that in pear paste, pears not only serve as a functional matrix. The polysaccharide-polyphenol-triterpene complex system forms a multi-target cough-relieving and anti-inflammatory network through dual regulation of TRPV1/TRPA1 ion channels, inhibition of the NLRP3 inflammasome, and metabolites of gut microbiota such as SCFAs. The research results provide a theoretical breakthrough for the modern development of pear paste and a scientific basis for the modernization of traditional preparations.

Ye Q, Zhu W, Wang Y, et al., 2022, Research on the Formulation and Application of the Ancient Prescription “Five-Juice Drink”. Chinese Journal of Ethnomedicine and Ethnopharmacy, 31(05): 68–70.

Song Y, 2022, A Pear Paste Rich in Pectin and Water-Soluble Dietary Fiber and Its Preparation Method: CN202210357062.2, patent, CN114668127A, viewed on February 6, 2025.

Zeng G, 2008, Study on the Inhibition of Mouse T-Cell Activation by Ursolic Acid through the NF-kB Signaling Pathway, thesis, Central South University, DOI: 10.7666/d.y1328119.

Yin H, 2018, Research on the Anti-inflammatory Effect of Polyphenolic Compounds by Inhibiting the NLRP3 Inflammasome, thesis, Shandong University.

Kuai Z, 2025, Design, Synthesis, and Antitumor Activity Research of Oleanolic Acid Derivatives, thesis, Shenyang University of Chemical Technology. DOI: CNKI:CDMD:2.1019.803577.

Kou Y, Xu D, Lin R, et al., 2023, Research on the Improvement Effect of Laiyang Pear Paste on Cough Model Mice. Feed Industry, 44(23): 92–97.

Chen Y, 2013, Research on the Micro-Structure and Degradation Pattern of Cell-Wall Polysaccharides in Stone Fruits after Harvest, thesis, Henan University of Technology.

Yang H, Jiang Q, Liu X, et al., 2023, Metabolomic Study on the Intervention of Atractylodes Macrocephala Polysaccharides in Ulcerative Colitis Based on UPLC-Q-TOF-MS Technology. Chinese Traditional and Herbal Drugs, 54(15): 4895–4904.

Zhang Q, Zhang J, Sui C, et al., 2012, Study on the Variation Law of Chlorogenic Acid Components in the Water-Extraction Process of Honeysuckle by HPLC-DAD-ESI-MS/MS. China Journal of Chinese Material Medical, 37(23) 3564–3568. DOI: CNKI:SUN:ZGZY.0.2012-23-016.

Zeng S, Lu B, Li P, et al., 2017, Analysis of the Formation of HMF in the Maillard Reaction System of Alanine and Glucose. Journal of the Chinese Institute of Food Science and Technology, 17(4): 5. DOI: 10.16429/j.1009-7848.2017.04.035.

Zhang P, 2023, Research on the Mechanism of Rosa Roxburghii Polysaccharides in Regulating the Composition of Gut Microbiota and the Function of Intestinal Mucosal Barrier, thesis, Henan University of Technology, DOI: 10.27791/d.cnki.ghegy.2023.000067.

Zhao P, Yang Z, Chen X, et al., 2023, Research Progress on the Intervention of Traditional Chinese Medicine in Atherosclerosis Based on the Regulation of the TRPV1/TRPA1-TLR/NLRP3 Pathway. Chinese Journal of Experimental Traditional Medical Formulae, 29(20): 247–256. DOI: 10.13422/j.cnki.syfjx.20231239.

Liu X, Li Z, Zhou X, et al., 2023, Biological Functions of Transient Receptor Potential Vanilloid Subfamily 1 (TRPV1). Progress in Biochemistry and Biophysics, 50(3): 437–447.

Duan N, Huang C, Pang L, et al., 2019, Study on the Regulation of Renal Injury-Related Molecules and Toll-like Receptor Signaling Pathway by Glycated Albumin and the Intervention Effect of Oleanolic Acid. Journal of Capital Medical University, 40(4): 6. DOI: 10.3969/j.issn.1006-7795.2019.04.021.

Wang T, Zheng N, Yuan X, et al., 2019, Analysis of the Structural Characteristics of Gut Microbiota in Experimental Colitis Mice Based on 16S rRNA High-Throughput Sequencing Technology. Journal of Diagnostic Concepts and Practice, 18(3): 8. DOI: CNKI:SUN:ZDLS.0.2019-03-006.