JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v9i6.10950ArticleEffectiveness of Remazolam Combined with Alfentanil for Fiberoptic Bronchoscopy in Elderly Debilitated Patientshttps://artdesignp.com/journal/JCNR/9/6/10.26689/jcnr.v9i6.10950ChaiFei,CaiQiaoying,LiuRongfang2025962025-07-02Objective: To analyze the application value of remazolam compound alfentanil anesthesia regimen in fiberoptic bronchoscopy in elderly debilitated patients. Methods: Seventy-two cases of elderly debilitated patients who underwent fiberoptic bronchoscopy in the Department of Respiratory Medicine of a hospital from August 2023 to July 2024 were selected, and were divided into the control group and the observation group using the mean score method, with 36 cases in each group. In both groups, 7–10 μg/kg alfentanil was injected intravenously after oxygen denitrification, and 1 min later propofol 1.5 mg/kg was given intravenously in the control group and remazolam 0.3 mg/kg was given intravenously in the observation group. Subsequently, mivacurium chloride 0.1mg/kg IV was given to both groups. Propofol 5mg/(kg-h) was given in the control group and remazolam 0.5mg/(kg-h) was given intravenously pumped in the observation group during anesthesia maintenance. Changes in vital signs such as HR, MAP and SpO2 and the occurrence of adverse reactions were recorded in the two groups before anesthesia administration (T1), at the moment of placing fiberoptic bronchoscope (T2), at the moment of placing the tracheal tube (T3), and at 1 min after placing the tracheal tube (T4). Results: Compared with T1, patients in the observation group had lower MAP at T2, T3, T4 and lower SpO2 at T3, T4 (P < 0.05); in the control group, HR slowed down at T2, T3, T4 and MAP and SpO2 decreased at T2, T3, T4 (P < 0.05). SpO2 at T3 and T4 was lower in both groups compared with that at T2 (P < 0.05). SpO2 at T4 was lower in the control group compared with that at T3 (P < 0.05). Compared with the control group, patients in the observation group suffered from increased HR and elevated MAP at T2, T3, and T4, and increased SpO2 at T3 and T4 (P < 0.05). The incidence of intraoperative hypotension and bradycardia in the observation group was lower than that in the control group, and the difference was statistically significant (P < 0.05). The incidence of intraoperative choking and coughing, postoperative hypoxemia, nausea and vomiting, and dizziness were found in the patients of both groups, drowsiness and other adverse reactions incidence rate comparison, the difference are not statistically significant (P > 0.05). Conclusion: Remazolam and alfentanil are used in fiberoptic bronchoscopy for elderly debilitated patients with remarkable effect, which can effectively improve the vital signs of patients, reduce the risk of intraoperative hypotension, bradycardia, and other adverse reactions, and have high anesthetic effectiveness and safety.

Cheng D, Liu YF, Yao YC, et al., 2025, Effectiveness of Remazolam Compounded With Alfentanil for Fiberoptic Bronchoscopy in Elderly Debilitated Patients. Journal of Zhengzhou University (Medical Edition), 60(1): 86–90.

Wei H, Zhang L, Li L, et al., 2022, Effect of Remazolam Compounded With Alfentanil for Gastroscopy in Debilitated Elderly Patients. Chinese Journal of Anesthesiology, 42(6): 708.

Minami D, Takigawa N, 2023, Safe Sedation During Diagnostic and Therapeutic Flexible Bronchoscopy in Japan: A Review of the Literature. Respir Investig, 61(1): 52.

Su G, Chen Y, Yu X, et al., 2024, Effective Dose Study of Remazolam Compounded With Alfentanil to Inhibit Cardiovascular Responses During Fiberoptic Bronchoscope Placement. Zhejiang Journal of Integrative Medicine, 34(7): 640–644.

Kang J, Yuan Y, Yu Y, et al., 2022, Progress of Clinical Research on Remazolam. Chinese Journal of Anesthesiology, 42(8): 1020–1024.

Wang J, Guo J, 2021, Clinical Pharmacological Properties of Alfentanil and Its Progress in Anesthetic Applications. Chinese Clinical Pharmacology and Therapeutics, 24(7): 824–829.

Chen S, Yuan T, Zhang J, et al., 2021, Remimazolam Tosilate in Upper Gastrointestinal Endoscopy: A Multicenter, Randomized, Non-Inferiority, Phase III Trial. Journal of Gastroenterology and Hepatology, 36(2): 474–481.

Xu Q, Wang L, Wu J, et al., 2023, Effectiveness of Alfentanil Compounded With Remazolam or Propofol for Transnasal Fiberoptic Bronchoscopic Tracheal Intubation. Jiangsu Medicine, 49(11): 1145–1147, 1151.

Zhang L, He L, Zhao E, et al., 2022, Effectiveness and Safety of Remazolam Compounded With Alfentanil for Painless Gastroscopy in Elderly Patients. Journal of Zhengzhou University (Medical Edition), 57(5): 689.

Liu Y, Hu J, Zhang F, et al., 2022, Different Doses of Alfentanil Combined With Propofol in Gastroscopy. Journal of Clinical Anesthesiology, 38(5): 487–491.

Wang J, Guo J. 2021, Clinical Pharmacological Properties of Alfentanil and Its Progress in Anesthetic Applications. Chinese Clinical Pharmacology and Therapeutics, 26(7): 824–829.

Qu M, Zhang T, Xing F, et al., 2021, Effectiveness of Remazolam–Alfentanil–Mivacurium Chloride for Fiberoptic Bronchoscopy. Chinese Journal of Anesthesiology, 41(5): 563.