JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v9i6.11059ArticleEvaluation of the Improvement of Blood Pressure Levels in Patients with Hypertensive Disorders of Pregnancy Treated with Labetalol Combined with Aspirinhttps://artdesignp.com/journal/JCNR/9/6/10.26689/jcnr.v9i6.11059ChenHao2025962025-07-07Objective: To evaluate the effect of labetalol combined with aspirin on improving blood pressure in patients with hypertensive disorders of pregnancy (HDP). Methods: Eighty-two patients with HDP who visited the hospital from August 2022 to August 2024 were selected as samples and randomly divided into two groups. Group A was treated with labetalol and aspirin, while Group B was treated with labetalol only. The efficacy, blood pressure, vascular endothelial function, coagulation indexes, and pregnancy outcomes were compared between the two groups. Results: The efficacy of Group A was higher than that of Group B (P < 0.05). The systolic blood pressure (SBP), diastolic blood pressure (DBP), and endothelin-1 (ET-1) in Group A were lower than those in Group B (P < 0.05). The prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), and fibrinogen (FIB) in Group A were all better than those in Group B (P < 0.05). The rate of adverse pregnancy outcomes in Group A was lower than that in Group B (P < 0.05). Conclusion: The combination of labetalol and aspirin for the treatment of HDP can stabilize blood pressure, optimize vascular endothelial function, improve coagulation indexes and pregnancy outcomes, which is highly effective and feasible.

Yu W, Wang Y, 2025, Effects of Labetalol Hydrochloride Combined With Phloroglucinol on Vascular Endothelial Function and Oxidative Stress Indices in Patients With Gestational Hypertension. Sichuan Journal of Physiological Sciences, 47(2): 372–375.

Liu H, Hou S, Jia R, Wang S, 2025, Effect of Low-Dose Aspirin Combined With Magnesium Sulfate in the Treatment of Early-Onset Preeclampsia. Henan Medical Research, 34(3): 511–515.

Liu T, Yang J, Jiang Y, 2024, Efficacy of Danshen Injection Combined With Low-Dose Aspirin and Labetalol in the Treatment of Gestational Hypertension. Jilin Medical Journal, 45(8): 1918–1921.

Cheng L, Jiang J, Wu J, 2024, Effects of Labetalol Combined With Low-Dose Aspirin on Pregnancy Outcomes and Blood Pressure Control in Patients With Gestational Hypertension. Heilongjiang Medicine, 37(5): 1092–1094.

Ye Y, Wang C, Fang R, 2024, Effect of Low-Dose Aspirin Combined With Sequential Labetalol Therapy in the Treatment of Gestational Hypertension. Journal of Clinical Rational Drug Use, 17(18): 132–135.

Wang Y, 2024, Clinical Efficacy of Labetalol Combined With Nifedipine in Patients With Gestational Hypertension and Preeclampsia. Contemporary Medicine Forum, 22(13): 99–101.

Wang W, 2022, Effect of Labetalol Combined With Magnesium Sulfate in the Treatment of Preeclampsia and Its Impact on Pregnancy Outcomes. Heilongjiang Medicine, 35(5): 1132–1135.

Zhang H, Zheng S, Yu Y, 2023, Efficacy of Low-Dose Aspirin Combined With Labetalol in the Treatment of Gestational Hypertension Syndrome and Its Impact on Coagulation Function and Pregnancy Outcomes. Journal of Clinical Rational Drug Use, 16(21): 38–41.

Guan X, Zhou Y, Zeng J, 2022, Effects of Low-Dose Aspirin Combined With Labetalol on Patients With Preeclampsia. Chinese and Foreign Medical Research, 20(10): 103–106.

Xiao L, Huang X, 2021, Effect of Low-Dose Aspirin as an Adjuvant Therapy on Patients With Early-Onset Preeclampsia and Its Impact on the Incidence of Adverse Pregnancy Outcomes. Journal of Mathematical Medicine, 34(10): 1503–1505.