JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v9i7.11281ArticleAdvancements in the Use of OCTA for Studying Intraocular Pressure and Retinal Perfusionhttps://artdesignp.com/journal/JCNR/9/7/10.26689/jcnr.v9i7.11281LiChaoxuan,ZhangWeiguo2025972025-07-25Optical coherence tomography angiography (OCTA) is a non-invasive imaging technique that analyzes the microvascular system of the eye. By capturing high-speed, repeated scans to detect the movement of red blood cells, OCTA visualizes the vascular network, revealing ischemia and reperfusion patterns in retinal vascular diseases. It has become a primary tool for assessing changes in the multilayer microvascular structure of the retina, applicable in conditions such as diabetic retinopathy, age-related macular degeneration, central serous chorioretinopathy, vascular occlusions, and glaucomatous optic neuropathy, among others. Moreover, OCTA is useful in the assessment of central nervous system diseases and is increasingly utilized in routine health examinations and scientific research. Its main advantages include high resolution, rapid, non-invasive scanning, and the ability to analyze microcirculation by observing different vascular layers through tomographic imaging. However, its sensitivity to blood flow velocity and susceptibility to artifacts, such as slow blood flow appearing as non-perfusion, are notable limitations. Overall, OCTA provides a visually intuitive approach for observing retinal blood flow and has significant clinical implications for ocular conditions.

Wright WS, Eshaq RS, Lee M, et al., 2020, Retinal Physiology and Circulation: Effect of Diabetes. Compr Physiol, 10(3): 933–974.

Kaya M, Ayhan Z, Ozturk AT, et al., 2021, Evaluation of the Macular and Choroidal Perfusion in Healthy Turkish Population Using Optical Coherence Tomography Angiography. Korean J Ophthalmol, 35(5): 360–367. doi: 10.3341/kjo.2020.0122.

Bajtl D, Bjelos M, Busic M, et al., 2021, Macular Perfusion Normative Data Acquired With Optical Coherence Tomography Angiography in Healthy Four-Year-Old Caucasian Children. BMC Ophthalmol, 21(1): 354. Oct 5 2021, doi: 10.1186/s12886-021-02122-y.

Li YK, Fung NS, Chan JCH, et al., 2023, OCTA Biomarkers in Adults Aged 50 and Above: A Prospective and Cross Sectional Community Based Study. BMC Ophthalmol, 23(1): 71.

Eastline M, Munk MR, Wolf S, et al., 2019, Repeatability of Wide Field Optical Coherence Tomography Angiography in Normal Retina. Transl Vis Sci Technol, 8(3): 6.

Hua D, Xu Y, Heiduschka P, et al., 2021, Retina Vascular Perfusion Dynamics During Exercise With and Without Face Masks in Healthy Young Adults: An OCT Angiography Study. Transl Vis Sci Technol, 10(3): 23.

Cai Y, Liu WB, Zhou M, et al., 2022, Diurnal Changes of Retinal Microvascular Circulation and RNFL Thickness Measured by Optical Coherence Tomography Angiography in Patients With Obstructive Sleep Apnea Hypopnea. Front Endocrinol (Lausanne), 13: 947586.

Liu L, Takusagawa HL, Greenwald MF, et al., 2021, Optical Coherence Tomographic Angiography Study of Perfusion Recovery After Surgical Lowering of Intraocular Pressure. Sci Rep, 11(1): 17251.

Tian M, Tappeiner C, Zinkernagel MS, et al., 2019, Swept Source Optical Coherence Tomography Angiography Reveals Vascular Changes in Intermediate Uveitis. Acta Ophthalmol, 97(5): e785–e791.

Gong Y, Hu L, Wang L, et al., 2022, WF SS OCTA for Detecting Diabetic Retinopathy and Evaluating the Effect of Photocoagulation on Posterior Vitreous Detachment. Front Endocrinol (Lausanne), 13: 1029066.

Ratra D, Dalan D, Prakash N, et al., 2021, Quantitative Analysis of Retinal Microvascular Changes in Prediabetic and Diabetic Patients. Indian J Ophthalmol, 69(11): 3226–3234.

Barraso M, Chilet AA, Hernandez T, et al., 2020, Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus. Report 1: Diabetic Retinopathy. Transl Vis Sci Technol, 9(10): 34.

Bacherini D, Dragotto F, Caporossi T, et al., 2021, The Role of OCT Angiography in the Assessment of Epiretinal Macular Membrane. J Ophthalmol, 2021: 8866407.

Yu S, Frueh BE, Steinmair D, et al., 2018, Cataract Significantly Influences Quantitative Measurements on Swept Source Optical Coherence Tomography Angiography Imaging. PLoS One, 13(10): e0204501.

Ch’ng TW, Gillmann K, Hoskens K, et al., 2020, Effect of Surgical Intraocular Pressure Lowering on Retinal Structures – Nerve Fibre Layer, Foveal Avascular Zone, Peripapillary and Macular Vessel Density: 1 Year Results. Eye (Lond), 34(3): 562–571.

Cheung CMG, Teo KYC, Tun SBB, et al., 2020, Differential Reperfusion Patterns in Retinal Vascular Plexuses Following Increase in Intraocular Pressure: An OCT Angiography Study. Sci Rep, 10(1): 16505.

Svjascenkova L, Laganovska G, Tzivian L, 2023, Microstructural Changes in the Macula Following Cataract Surgery in Patients With Type 2 Diabetes Mellitus Detected Using Optical Coherence Tomography Angiography. Diagnostics (Basel), 13(4): 0605.

Baldascino A, Ripa M, Carla MM, et al., 2022, Optical Coherence Tomography Angiography to Estimate Early Retinal Blood Flow Changes After Uncomplicated Cataract Surgery. Vision (Basel), 6(3): 0038.

Busch C, Wakabayashi T, Sato T, et al., 2019, Retinal Microvasculature and Visual Acuity After Intravitreal Aflibercept in Diabetic Macular Edema: An Optical Coherence Tomography Angiography Study. Sci Rep, 9(1): 1561.

Li H, Bui BV, Cull G, et al., 2017, Glial Cell Contribution to Basal Vessel Diameter and Pressure Initiated Vascular Responses in Rat Retina. Invest Ophthalmol Vis Sci, 58(1): 1–8.

Bernal Morales C, Ale-Chilet A, Martin-Pinardel R, et al., 2021, Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus. Report 4: Glycated Haemoglobin. Diagnostics (Basel), 11(9): 1537.

Harris NR, Leskova W, Kaur G, et al., 2019, Blood Flow Distribution and the Endothelial Surface Layer in the Diabetic Retina. Biorheology, 56(2–3): 181–189.

Chai Q, Yao Y, Guo C, et al., 2022, Structural and Functional Retinal Changes in Patients With Type 2 Diabetes Without Diabetic Retinopathy. Ann Med, 54(1): 1816–1825.

Wei P, Falardeau J, Chen A, et al., 2022, Optical Coherence Tomographic Angiography Detects Retinal Vascular Changes Associated With Pituitary Adenoma. Am J Ophthalmol Case Rep, 28: 101711.

Liu R, Wang Y, Xia Q, et al., 2022, Retinal Thickness and Microvascular Alterations in the Diagnosis of Systemic Lupus Erythematosus: A New Approach. Quant Imaging Med Surg, 12(1): 823–837.

Guemes Villahoz N, Burgos-Blasco B, Vidal-Villegas B, et al., 2021, Reduced Retinal Vessel Density in COVID 19 Patients and Elevated D Dimer Levels During the Acute Phase of the Infection. Med Clin (Barc), 156(11): 541–546.

Garcia Medina JJ, Rubio-Velazquez E, Lopez-Bernal MD, et al., 2020, Optical Coherence Tomography Angiography of Macula and Optic Nerve in Autism Spectrum Disorder: A Pilot Study. J Clin Med, 9(10): 3123.

Li X, Zhu S, Zhou S, et al., 2021, Optical Coherence Tomography Angiography as a Noninvasive Assessment of Cerebral Microcirculatory Disorders Caused by Carotid Artery Stenosis. Dis Markers, 2021: 2662031.

Shin YU, Lee DE, Kang MH, et al., 2018, Optical Coherence Tomography Angiography Analysis of Changes in the Retina and the Choroid After Haemodialysis. Sci Rep, 8(1): 17184.

Zhang X, Liu W, Zhang Z, et al., 2022, Analysis of Macular Blood Flow Changes in Thyroid Associated Ophthalmopathy. BMC Ophthalmol, 22(1): 501.

Hepschke JL, Laws E, Saliman NHB, et al., 2023, Modifications in Macular Perfusion and Neuronal Loss After Acute Traumatic Brain Injury. Invest Ophthalmol Vis Sci, 64(4): 35.

Suzue M, Shiraki N, Sakimoto S, et al., 2023, Optical Coherence Tomography Angiography Imaging in Peripheral Commotio Retinae: A Case Report. Am J Ophthalmol Case Rep, 32: 101894.

Su Y, Zhang S, Zhang G, et al., 2022, Quantification of Peripapillary Vessel Density in Non Arteritic Anterior Ischemic Optic Neuropathy Patients With Optical Coherence Tomography Angiography. Quant Imaging Med Surg, 12(2): 1549–1557.