Correlation Analysis Between Symptom Clusters and Quality of Life in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

JCNR

Journal of Clinical and Nursing Research

2208-36852208-3693

Bio-Byword Scientific Publishing Pty. Ltd.

10.26689/jcnr.v9i8.11746

Article

Correlation Analysis Between Symptom Clusters and Quality of Life in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Diseasehttps://artdesignp.com/journal/JCNR/9/8/10.26689/jcnr.v9i8.11746WangWenjie,WangNa,WangYujiao,LiuDan

2025

2025-09-04

Objective: This study aims to investigate the patterns of symptom occurrence in patients experiencing acute exacerbations of chronic obstructive pulmonary disease (AECOPD). It will explore the composition of symptom clusters and analyze the correlation between these clusters and health-related quality of life (HRQoL). Methods: A total of 207 patients with AE-COPD were surveyed from a tertiary grade A hospital. Data collection was conducted using three validated instruments: the Basic Information Questionnaire (BIQ), Disease Symptom Survey Questionnaire (MSAS), and Quality of Life Questionnaire (CAT). Statistical software SPSS 22.0 was used to analyze the correlation between symptom clusters and quality of life. Results: Exploratory factor analysis showed that five major symptom clusters existed in the patients, including the psycho-emotional symptom cluster, the sleep-related symptom cluster, the other side effects symptom cluster, the energy deficiency symptom cluster and the cough-loss of appetite symptom cluster, and the severity of the symptom clusters showed a significant negative correlation with the quality of life of the patients (P < 0.05). Conclusion: Strengthening the comprehensive management of symptom clusters in patients with AE-COPD can help to effectively reduce the symptom burden of patients, and then significantly improve their quality of life.

Kong D, Fan Z, 2021, Progress of Research on the Correlation Between Chronic Obstructive Pulmonary Disease and Air Pollution. China Public Health, 37(9): 1438–1442.

Li L, Cui M, Zhao L, 2012, Role of Breathing Training on Fatigue in Stable COPD Patients. Journal of Nurse Advancement, 27(15): 1398–1400.

Yang H, Shi X, Wang D, et al., 2019, Progress of Research on Early Warning of Acute Exacerbation of Chronic Obstructive Pulmonary Disease. International Respiratory Journal, 39(12): 5.

Theander K, Jakobsson P, Torstensson O, et al., 2008, Severity of Fatigue Is Related to Functional Limitation and Health in Patients With Chronic Obstructive Pulmonary Disease. International Journal of Nursing Practice, 14(6): 455–462.

Yang ZJ, Cui ML, Zhang SF, et al., 2021, Symptom Clusters and Their Correlation With Inflammatory Factor Levels in Patients With Chronic Obstructive Pulmonary Disease. Nursing Research, 35(7): 1134–1139.

Chen QM, Cui ML, Ma YE, 2022, Investigation and Study of Symptom Clusters and Antecedent Symptoms in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Chinese Journal of Nursing, 57(23): 2891–2897.

Yohannes AM, Murri MB, Hanania NA, et al., 2022, Depressive and Anxiety Symptoms in Patients With COPD: A Network Analysis. Respiratory Medicine, 198: 106865.

Wiklund I, Berry P, Lu K, et al., 2010, The Chinese Translation of the COPD Assessment Test (CAT) Provides a Valid and Reliable Measurement of COPD Health Status in Chinese COPD Patients. American Thoracic Society 2010 International Conference, New Orleans, USA.

Li Y, Chen L, Shi L, et al., 2013, Effects of Chronic Obstructive Pulmonary Disease Symptom Clusters on Functional Status in Elderly Patients. Guangdong Medicine, 34(21): 3319–3322.

Lee AL, Harrison SL, Goldstein RS, et al., 2018, An Exploration of Pain Experiences and Their Meaning in People With Chronic Obstructive Pulmonary Disease. Physiother Theory Practice, 34(10): 765–772.

Lim KE, Kim SR, Kim HK, et al., 2017, Symptom Clusters and Quality of Life in Subjects With COPD. Respiratory Care, 62(9): 1203–1211.

Tian J, Chen X, Wang J, 2018, Correlation of the Modified British Medical Research Council Dyspnea Scale Score and Chronic Obstructive Pulmonary Disease Assessment Test Score With Pulmonary Function in Patients With Chronic Obstructive Pulmonary Disease and Their Predictive Value for Pulmonary Hypertension. Journal of Practical Heart, Brain, Lung and Vascular Disease, 26(12): 44–48.

Wu R, Quan H, Wang C, et al., 2019, Applied Research on Respiratory Rehabilitation in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Industrial Hygiene and Occupational Disease, 45(6): 436–439.

Zhou M, Wang G, Zhu L, et al., 2020, Research on the Effect of Early Pulmonary Rehabilitation Exercise on Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Chinese Journal of Preventive Medicine, 21(04): 110–113.

Wang Q, Yang B, Feng L, 2020, Research Exhibition on Early Pulmonary Rehabilitation of Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease After Hospital Discharge. Chinese Journal of Modern Rehabilitation, 12(26): 3563–3566.

Ou M, Liu Y, Guo H, et al., 2018, Research Progress on the Effect of Taijiquan on the Rehabilitation of Patients With Stable Chronic Obstructive Pulmonary Disease. Modern Clinical Nursing, 17(01): 59–64.