JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v9i9.11734ArticleMethimazole-induced Acute Kidney Injury during the Initial Treatment for Graves’ Disease: a Rare Case Report and Literature Reviewhttps://artdesignp.com/journal/JCNR/9/9/10.26689/jcnr.v9i9.11734ZhaiXiaohan,ShiHongyan,LiXiang,WangAihong,WangBin2025992025-10-22As a commonly used oral drug for the treatment of hyperthyroidism, methimazole has common adverse reactions such as a granulocytopenia, thrombocytopenia, arthralgia, skin allergy, etc. The reports of kidney injury caused by methimazole are rare, and the clinical understanding is insufficient, so it is easy to misdiagnosis. This paper reports a middle-aged male patient who was diagnosed with hyperthyroidism in our hospital and developed acute kidney disease after treatment with methimazole. Creatinine and kidney injury-related protein levels decreased after treatment with methimazole. After the primary disease was excluded, acute kidney injury caused by methimazole was highly suspected. The aim of this paper is to improve the safety of methimazole and reduce the rate of missed diagnosis and misdiagnosis.

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