JCNRJournal of Clinical and Nursing Research2208-36852208-3693Bio-Byword Scientific Publishing Pty. Ltd.10.26689/jcnr.v9i9.12273ArticleResearch Progress on Hydrogen-Rich Water in Improving Ocular Surface Diseases and Oxidative Stresshttps://artdesignp.com/journal/JCNR/9/9/10.26689/jcnr.v9i9.12273MaNanxing2025992025-10-16The occurrence and development of ocular surface diseases are closely related to oxidative stress. Excessive accumulation of reactive oxygen species (ROS) can lead to ocular surface cell damage and inflammatory responses. As a new type of antioxidant, hydrogen-rich water (HRW) has shown intervention potential in ocular surface diseases such as dry eye and conjunctivitis by selectively scavenging toxic ROS, inhibiting inflammatory pathways, and protecting ocular surface cells. Combining basic mechanisms and clinical evidence, this article explores the application value of hydrogen-rich water in ocular surface diseases, providing new ideas for the prevention and treatment of oxidative stress-related eye diseases.

Chen W, Yu Y, 2025, Research Progress on the Pathogenesis and Therapeutic Methods of Ocular Surface Pain in Dry Eye. Chinese Journal of Chinese Ophthalmology, 35(08): 773–778.

Wang W, Chen J, Wang Y, et al., 2014, Research Progress on the Relationship Between Oxidative Stress and Ocular Surface Diseases. Recent Advances in Ophthalmology, 34(06): 585–588.

Ohsawa I, Ishikawa M, Takahashi K, et al., 2007, Hydrogen Acts as a Therapeutic Antioxidant by Selectively Reducing Cytotoxic Oxygen Radicals. Nature Medicine, 13(6): 688–694.

Chong J, 2022, Research Progress on the Pathogenesis and Surgical Treatment of Dry Eye. Chinese and Foreign Medical Research, 20(33): 181–184.

Zhang Y, Kang J, Liu C, et al., 2025, Mechanism Study of Yiqi Congming Decoction in Alleviating Dry Eye in Rats by Activating the Nrf2/HO-1 Pathway to Regulate Oxidative Stress. Recent Advances in Ophthalmology, 45(10): 781–786.

Zheng H, Dong H, Zhao T, et al., 2025, Research Progress on the Role of the NF-κB Pathway in Dry Eye. Journal of Inner Mongolia Medical University, 47(03): 324–328.

Cheng C, Yang H, 2023, Research Progress on the Mechanism of Celastrol in the Treatment of Ophthalmic Diseases. Chinese Journal of Chinese Ophthalmology, 33(11): 1075–1078.

Luo Q, Zhang C, 2024, Research Progress on the Mechanism of Keratoconus in Vernal Keratoconjunctivitis. International Eye Science, 24(07): 1084–1087.

Zhang L, Xi X, 2006, Research Progress on the Molecular Biology of the Pathogenesis of Pterygium. International Eye Science, (06): 1404–1406.

Chen X, Cai J, Cheng J, et al., 2018, Effect of Hydrogen-Rich Water on Oxidative Stress in Orbital Fibroblasts from Patients with Thyroid-Associated Ophthalmopathy Cultured in Vitro. Academic Journal of Second Military Medical University, 39(05): 547–551.

Chen X, Zhou X, Wei R, 2018, Research Progress on the Effect of Hydrogen-Rich Water on Ocular Diseases. Chinese Journal of Ophthalmology, 54(8): 631–635.

Lu R, Liu Y, Wang D, 2019, Protective Effect of Hydrogen-Rich Water on Oxidative Stress Cell Models and Its Influence on the PI3K/Akt Signaling Pathway. Chinese Critical Care Medicine, 31(6): 762–767.

He J, Xun Z, Xie F, et al., 2021, Effect of Long-Term Consumption of Hydrogen-Rich Water on the Physiological Functions of Normal Rats. Current Biotechnology, 11(3): 353–360.

Li Y, Zhang J, Zhou X, et al., 2021, Hydrogen Promotes Wound Healing by Inhibiting Oxidative Stress. Chinese Journal of Experimental Surgery, 38(7): 1260–1263.

Li X, Sun X, Wang Z, et al., 2018, Effect of Hydrogen-Rich Water on Apoptosis of Rat Isolated Myocardial Cells with Ischemia-Reperfusion Injury. The Journal of Practical Medicine, 34(20): 3356–3361.

Chen X, 2018, Effect of Hydrogen Water on Orbital Fibroblasts from Patients with Thyroid-Associated Ophthalmopathy Cultured in Vitro, thesis, Naval Medical University of the Chinese People’s Liberation Army.

Liu H, Huang Y, Zhang Y, et al., 2014, Establishment of a Rat Dry Eye Model and Changes in Its Corneal Nerves. Recent Advances in Ophthalmology, 34(05): 422–427.

Sui J, Wang Z, Liu H, et al., 2024, Study on the Protective Effect of Hydrogen-Rich Water on a Mouse Model of Acute Liver Injury. Medical Information, 37(19): 19–26.

Gao T, Ning D, Zhou Z, et al., 2024, Research Progress on the Therapeutic Effect of Hydrogen-Rich Water in Metabolic Diseases. Shaanxi Medical Journal, 53(08): 1139–1144.

Sui J, 2023, Anti-Inflammatory Activity of Hydrogen-Rich Water and Its Protective Effect on Mouse Liver, thesis, Hebei University of Engineering.

Yang M, Zhang H, Li Q, et al., 2018, Regulation of Oxidative Stress-Related Gene DUSP1 by Multiple microRNAs. Military Medical Sciences, 42(11): 834–838.

Xue Y, Song J, 2023, Research Progress on the Biological Mechanism of Hydrogen and Its Application in Clinical Diseases. Journal of Xinxiang Medical University, 40(05): 483–489.