OTDOncology Treatment Discovery3083-49962981-8079Bio-Byword Scientific Publishing Pty. Ltd.10.26689/otd.v2i4.9238ArticleCase Report: B-cell Acute Lymphoblastic Leukemia/Lymphoma Following Castleman Diseasehttps://artdesignp.com/journal/OTD/2/4/10.26689/otd.v2i4.9238ZhaoMeng,LiQirui,JiangTao,XuDafei,MaQian,TaoLunfei,MiaoZiwei2025242025-01-01Castleman disease (CD) is a rare nonmalignant lymphoproliferative disorder presenting systemic symptoms such as fever, night sweats, fatigue, anemia, effusions, and multifocal lymphadenopathy. The etiology of CD has not been clarified to date. The coexistence of CD with B-cell acute lymphoblastic leukemia/lymphoma (B-ALL/LBL) has been rarely reported. Although the pathogenesis remains unclear, this association probably reflects an incidental and fortuitous finding rather than the alteration of a common pluripotent stem cell precursor. Herein, the study reports on one case of CD coexisting with B-ALL/LBL and elucidates the underlying mechanism of pathology in some aspects.

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